04/01/2026
How would you rate Rena and Wendy’s perimenopausal IDGAF faces? For those of you going through the same transition, at some point in time you might notice improved emotional stability, less anxiety and/or less caring about what others think. Why? The amygdala is the brain’s emotional processing center and is activated when we feel fear or a threat, a warning system for initiating fight or flight. It is also a storage area for memories with strong emotions. This part of the brain changes as women age. In perimenopause, the fluctuating estrogen levels create a hypersensitivity resulting in mood swings, irritability and anxiety. But as time goes on and hormones stabilize, the drop in estrogen causes the amygdala to downregulate. This means women become less reactive to negative stimuli. At the same time, the prefrontal cortex becomes more active leading to better control over emotional responses. Ultimately, this manifests in less anxiety, better emotional regulation and a lot more I don’t give a f #.
Perimenopause and menopause are fascinating physiological transitions from a Classical Chinese medicine perspective. Let us know if you’re interested in learning more!