05/29/2026
Is Oppositional Deifiance Actually Anxiety?
Oppositional defiance can cause a tremendous amount of suffering for both children and their families. I have long thought of it as another face of anxiety — one that too often leads to social isolation and rejection.
In this reel, I share research from the Walsh Research Institute showing that 85% of children diagnosed with oppositional defiance had a methylfolate imbalance (relatively high folate), which can contribute to lower serotonin activity. Undermethylation also appears to be a common root of anxiety and depression. Here I also discuss traits associated with undermethylation and related diagnoses.