IP-6 Research

02/12/2026

Another report on the potential benefit of IP6 in ulcerative colitis:

02/11/2026

Chatterjee et al report that in a mouse model, "... oral InsP6 (Phytic acid) treatment is effective in reducing intestinal permeability" as in inflammatory bowel diseases (IBD)

The study finds that IPMK and InsP6activate HDAC3 to preserve gut integrity. Loss of IPMK impairs this axis, causing leaky gut, while InsP6 restores HDAC3 function, offering a potential therapy for inflammatory bowel disease.

02/06/2026

IP6 and inositol prevent steatohepatitis (MASH pathologies) in a mouse model.

11/26/2025

A fairly comprehensive review article on biological functions of IP6, from the history to the current day: Just came out:

Inositol hexaphosphate (IP6), also known as phytic acid, has historically been classified as an antinutrient due to its mineral-chelating properties, which were believed to impair nutrient absorption. Early reports fueled concerns that high dietary phytate intake could contribute to mineral deficien...

11/22/2025

IP6 prevents hearing loss in mouse models!

Background and Purpose Inositol hexaphosphate (IP6) is a natural carbohydrate compound in plants and mammalian cells. We aimed to investigate whether IP6 could protect cochlear hair cells and amelio...

11/17/2025

IP6 mitigates radiotherapy-related complications https://www.cell.com/cell-chemical-biology/abstract/S2451-9456(25)00346-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945625003460%3Fshowall%3Dtrue

09/20/2025

IP6 protects cornea:

09/03/2025

Dr Shamsuddin’s IP6 Original coming soon:

🌍 IP-6 Research Inc. – Setting the Global Standard for IP-6 Supplements 🌱 For 30+ years, Dr. Abulkalam M. Shamsuddin has pioneered IP-6 (Inositol Hexaphosphate) research — transforming it from a university discovery into a trusted global supplement standard. ✨ His vision was clear: purit...

08/23/2025

COVID-19 has been associated with olfactory disturbances in many infected patients. IP6 has beneficial role on improving the olfactory function after COVID-19.

Sodium phytate has benefit role on improving the olfactory function after COVID-19.

07/27/2025

IP-6 Research is advancing an exciting strategic research collaboration with BioLink Therapeutics, INDIA (https://BioLinkTherapeutics.com), aimed at unlocking the full therapeutic potential of IP6 far beyond its traditional role as a dietary supplement. Together, the two organizations are pioneering innovative research programs focused on developing IP6-based medicines. This international partnership combines BioLink’s translational drug development expertise with IP-6 Research Inc.’s deep scientific foundation, paving the way for a new class of therapeutics that could transform the landscape of chronic disease management.

07/10/2025

IP6 improves skin barrier function in an experimental model of Atopic Dermatitis (eczema) thereby potentially being useful as skin cream in this condition: https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16644

06/07/2025

IP6 in Bone Health

Dietary phytic acid/phytate/myo-inositol hexaphosphate (IP6), a phosphate reservoir in plants, was viewed as antinutrient, caused by an influence on the bioavailability of minerals through its chelating activity. However, there is a growing body of ...