09/07/2025
Cachexia, or significant weight and muscle loss due to illness, is a common problem among pancreatic cancer patients, and the issue is much more complex than getting a patient to eat more.
Cancer cells take nutrients from a person’s body by hijacking the body’s normal signaling pathways and directing that fuel to its own benefit.
“Eventually cachexia becomes a multi-organ disease, where you get lots of the parts of the body that fail,” says Andrea Galmozzi, PhD, a researcher who specializes in metabolic disorders.
Galmozzi and Adam Kuchnia, PhD, a researcher specializing in nutrition and muscle health, are working together to improve early diagnosis and develop targeted treatment to lessen cachexia’s impacts and improve patient survivorship.
Kuchnia’s work focuses on identifying early biomarkers of muscle wasting associated with cachexia that can be seen through clinical imaging. While cachexia is a serious complication, not all patients will develop it, so Kuchnia is comparing imaging in both groups to find the diagnosable warning signs.
Early detection would improve treatment options and help patients maintain their strength to continue treatments. Right now, there is no FDA-approved treatment to cure cancer-related cachexia. Instead, treatments are focused on increasing patient appetite and eating high protein and high calorie foods.
Their research is supported in part by money raised through the annual Roll & Stroll for Pancreas Cancer fundraiser, happening this year on August 10 at Capital Brewery in Middleton, WI. This family-friendly event is organized by the Pancreas Cancer Task Force, a volunteer group of cancer survivors, caregivers and advocates who support new research as well as patient services at Carbone.
Learn more: https://uw.health/3GFekw6