DeSoto Regional Health System

DeSoto Regional Health System DeSoto Regional Health System

DeSoto Regional Health System is comprised of an acute care, 38-bed, not-for-profit hospital, 3 rural health clinics, and wellness facility. DRHS provides a wide ranges of services and strives to create a comfortable, hometown environment while emphasizing compassionate, personal care. The DeSoto Regional Medical Staff includes 4 active-staff physicians, 3 employed nurse practitioners, 1 employed physician’s assistant, 117 courtesy physicians, 20 courtesy allied health professionals, and over 216 employees. Our areas of service include: Cardiology, Diagnostic Radiology, ENT, Emergency Medicine, Fitness/Wellness, Gastroenterology, Primary Care, General Surgery, Hematology/Oncology, Nephrology, Neurology, Ophthalmology, Orthopedics, Therapy Services, Podiatry, and Urology

02/19/2026
The first health fair of 2026 is coming up.Join us March 6 at First United Methodist Church, 502 Polk St, in Mansfield.C...
02/17/2026

The first health fair of 2026 is coming up.

Join us March 6 at First United Methodist Church, 502 Polk St, in Mansfield.

Come connect with local health resources, ask questions, and take a step toward better wellness. Open to the community and free to attend.

Daily Lunch Menu - February 16-20, 2026
02/17/2026

Daily Lunch Menu - February 16-20, 2026

Current Job Postings - February 6, 2026
02/06/2026

Current Job Postings - February 6, 2026

02/06/2026

Commemorative bricks at DeSoto Regional Health System offer a unique opportunity to leave your mark while supporting quality care in our community.

If you are interested or have questions, reach out to Terri Byrd at 318-872-4610 for more information.

Daily Lunch Menu - February 9-13, 2026
02/05/2026

Daily Lunch Menu - February 9-13, 2026

DeSoto Regional Health System is hosting a blood drive (platelet donations also accepted) today until 4:00pm in the Admi...
02/04/2026

DeSoto Regional Health System is hosting a blood drive (platelet donations also accepted) today until 4:00pm in the Administrative Conference Room of the hospital. Donate today!

A fresh chapter is literally being written into the framework at DeSoto Regional. Today, our Nursing and Rehabilitation ...
01/30/2026

A fresh chapter is literally being written into the framework at DeSoto Regional. Today, our Nursing and Rehabilitation teams left their signatures on the steel, marking their place in the future of care here at home.

Every name tells a story of long shifts, steady hands, and a commitment to helping patients heal and regain strength. It is a simple act, but a meaningful reminder that this new space is being built by the very people who will bring it to life each day.

Here’s to the teams shaping the next fifty years of care in our community.

Daily Lunch Menu - February 2-6, 2026
01/30/2026

Daily Lunch Menu - February 2-6, 2026

01/29/2026

UPDATE:

Fitness First will reopen tomorrow morning at 5:30 for regular operation

01/28/2026

UPDATE:

TheraTeam (located within Fitness First) will be open and seeing patients today starting at 10am; however, Fitness First gym will remain closed for the time being.

Address

207 Jefferson Street
Mansfield, LA
71052

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Our Story

DeSoto Regional Health System is comprised of an acute care, 38-bed, not-for-profit hospital, 3 rural health clinics, and wellness facility. DRHS provides a wide ranges of services and strives to create a comfortable, hometown environment while emphasizing compassionate, personal care. The DeSoto Regional Medical Staff includes 4 active-staff physicians, 3 employed nurse practitioners, 1 employed physician’s assistant, 117 courtesy physicians, 20 courtesy allied health professionals, and over 216 employees. Our areas of service include: Cardiology, Diagnostic Radiology, ENT, Emergency Medicine, Fitness/Wellness, Gastroenterology, Primary Care, General Surgery, Hematology/Oncology, Nephrology, Neurology, Ophthalmology, Orthopedics, Therapy Services, Podiatry, and Urology