02/12/2026
Interesting
Fulvic acid is a natural, yellow-brown colored organic compound formed by the breakdown of plant and animal materials by microorganisms in soil, peat, and water. It is a key component of humus (soil organic matter) and is highly valued for its ability to dissolve minerals and improve nutrient absorption in both plants and humans. New research is showing fulvic acid has the ability to induce cancer cell death within just 14 hours. The exact mechanisms are still being researched and appear to vary depending on the type of cancer cells.
🗂️Key mechanisms identified in preclinical research include:
đź“‘Induction of Apoptosis (Programmed Cell Death): Fulvic acid has been shown to induce apoptosis in various cancer cell lines, including ovarian, liver, lung, and breast cancer cells. This process involves a cascade of intracellular events, such as the reduction of anti-apoptotic proteins (like Bcl-2) and DNA fragmentation, leading to the self-destruction of cancerous cells.
đź“‘Inhibition of Proliferation and Metastasis: It suppresses the growth, migration, and invasion of cancer cells, which are key aspects of tumor progression and metastasis.
đź“‘Immune System Modulation: Fulvic acid may enhance the immune response against cancer. It can stimulate immune cells, such as macrophages, to produce anti-cancer mediators like nitric oxide (NO) and reactive oxygen species (ROS), which can then induce apoptosis in nearby cancer cells.
đź“‘Regulation of Specific Genes and Pathways:
🗒️In ovarian cancer cells, fulvic acid upregulates the expression of the gene CYP1A1, which is believed to act as a tumor suppressor in this context.
🗒️In non-small-cell lung cancer (NSCLC) studies, it inhibits the COX-2/PGE2/EP4 signaling pathway, which is critical for tumor growth and metastasis.
đź“‘Antioxidant and Pro-oxidant Effects: Fulvic acid exhibits a dual effect, acting as an antioxidant to protect healthy cells from oxidative stress while potentially inducing oxidative stress (ROS production) in cancer cells to trigger their death.