03/12/2026
A large clinical trial is performed to evaluate the treatment response to statins in statin-naive patients admitted for angina chest pain. Patients are randomly assigned to moderate- or high-dose statin therapy upon discharge. At 3 months, the adverse cardiovascular event rate in the high-dose group compared to the moderate-dose group was 0.98 with a p value of 0.80. At 1 year, the relative risk ratio was 0.67 with a p value of 0.01. Treatment and follow-up compliance was high in both groups throughout the study interval. The difference between the 2 risk estimates is best explained by which of the following?
A. Confounding bias
B. Latency period
C. Observer bias
D. Selection bias
E. Selective survival bias
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A large clinical trial is performed to evaluate the treatment response to statins in statin-naive patients admitted for angina chest pain. Patients are randomly assigned to moderate- or high-dose statin therapy upon discharge. At 3 months, the adverse cardiovascular event rate in the high-dose group...