06/30/2025
Derm Index: Your Guide to Jessner Lymphocytic Infiltrate
Jessner lymphocytic infiltration of the skin (JLIS) is a rare, benign dermatological condition that manifests as a persistent, papular, and plaque-like eruption. Characterized by a protracted course with periods of remission and occasional spontaneous resolution, JLIS typically affects individuals under 50 years of age, though the exact prevalence remains unknown. While some studies suggest a male predominance, others report no gender bias. Additionally, familial cases have been documented, suggesting a potential genetic predisposition.
Etiology and Pathogenesis
The exact cause of JLIS is still undetermined; however, several theories have been proposed. Some research indicates a potential association between JLIS and the bacterium Borrelia burgdorferi, the causative agent of Lyme disease, while other studies have implicated photosensitivity as a triggering factor. Furthermore, a subset of clinicians hypothesizes that JLIS may represent a variant of lupus erythematosus, given some overlapping clinical features and immunological similarities.
Clinical Presentation
Patients with JLIS are often asymptomatic, although some may experience mild symptoms such as pruritus or a burning sensation in the affected areas. The characteristic lesions are erythematous, non-scaly papules and plaques, ranging from 2 mm to 2 cm in size. These lesions most commonly appear on the face, neck, and back but can also affect the trunk and extremities. Over time, the lesions may expand peripherally, potentially forming well-demarcated rings with central clearing, a feature that can aid in diagnosis.
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