American Society of Pediatric Nephrology

American Society of Pediatric Nephrology The ASPN is an organization of pediatric nephrologists and affiliated health care professionals.

Our primary goals are to promote optimal care for children with kidney disease through advocacy,
education and research; and to disseminate advances in clinical practice and scientific investigation.

Conventional cytotoxic chemotherapy-associated nephrotoxicity
03/31/2026

Conventional cytotoxic chemotherapy-associated nephrotoxicity

The sub-field of onco-nephrology has rapidly grown with the proliferation of highly effective cancer therapies and the remarkable improvement in patient survival. Conventional cytotoxic chemotherapy is a backbone of cancer therapy, often employed alone or with targeted agents and immunotherapies. Ho...

Techniques to predict survival outcomes in nephrology: basics and traditional methods
03/30/2026

Techniques to predict survival outcomes in nephrology: basics and traditional methods

Predicting survival outcomes is one of the most crucial tasks that nephrologists face. On an individual level, predicted survival times affect all aspects of decision-making, including the initiation of dialysis or the consideration of transplantation. On a larger scale, interventions and therapeuti...

Reduced podocyte stiffness is a feature of proteinuric kidney disease
03/30/2026

Reduced podocyte stiffness is a feature of proteinuric kidney disease

Proteinuria is a common and important manifestation of glomerular injury. Although the molecular events driving proteinuria have been studied extensively, the biomechanical changes that occur in the glomerulus remain largely unexplored.

Review: Cancer Therapy and the Kidney
03/30/2026

Review: Cancer Therapy and the Kidney

The rapid evolution of anti-cancer therapies has significantly improved outcomes for patients with malignancies. However, these advances have also been accompanied by a rise in nephrotoxicity associated with anti-cancer therapies. Acute kidney injury (AKI), chronic kidney disease (CKD), hypertension...

Review: Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges an...
03/29/2026

Review: Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges and opportunities

“The tropics” currently account for around 40% of the world’s population and face unique environmental challenges with limited resources, a deficient health system, a rudimentary sanitary infrastructure in addition to a lack of adequate preventive measures and poor surveillance programs. Cases...

Case report: Perrault Syndrome Unmasked: Genomic Reclassification of a Fabry-Like CKDx Phenotype
03/29/2026

Case report: Perrault Syndrome Unmasked: Genomic Reclassification of a Fabry-Like CKDx Phenotype

A 30-year-old female was admitted to the nephrology ward for the evaluation of chronic kidney disease (CKD) of unexplained cause (CKDx), initially raising concern for Fabry disease. She had congenital sensorineural hearing loss and received bilateral cochlear implant surgery at the age of 13 and 26....

03/29/2026

A study of body composition, muscle strength, and arterial stiffness in adolescents with primary and secondary hypertension

Background Hypertension in adolescents is associated with early cardiovascular risk, yet functional and vascular differences between primary and secondary hypertension remain poorly characterized. This study aims to compare body composition, muscle strength, arterial stiffness, physical activity, an...

T-cell receptor Vβ repertoire skewing reflects premature immune senescence in children with chronic kidney disease
03/28/2026

T-cell receptor Vβ repertoire skewing reflects premature immune senescence in children with chronic kidney disease

Background Chronic kidney disease (CKD), characterized by chronic inflammation and uremic toxicity, represents a state of premature immune aging. However, data on T-cell receptor (TCR) repertoire alterations in pediatric CKD are limited. The TCR variable beta (Vβ) region defines distinct T-cell sub...

Case report: Recurrent pancreatitis and atypical hemolytic uremic syndrome (aHUS): an unusual presentation in childhood
03/28/2026

Case report: Recurrent pancreatitis and atypical hemolytic uremic syndrome (aHUS): an unusual presentation in childhood

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by the classical triad of acute hemolytic anemia, thrombocytopenia, and kidney impairment. We report a 10-year-old boy with acute pancreatitis presenting simultaneously with atypical HUS (aHUS) with two such episodes occur...

The epidemiology of kidney and urinary tract infections in pediatric chronic kidney disease: prevalence, risk factors an...
03/28/2026

The epidemiology of kidney and urinary tract infections in pediatric chronic kidney disease: prevalence, risk factors and association with GFR decline in the Chronic Kidney Disease in Children Study

Background Urinary tract and kidney infections are potential complications in pediatric chronic kidney disease (CKD), especially among patients with congenital anomalies of the kidney and urinary tract (CAKUT). We characterized the prevalence of self-reported infections from childhood through young....

Demographics, longitudinal changes and outcome of high blood pressure in children and adolescents on kidney replacement ...
03/28/2026

Demographics, longitudinal changes and outcome of high blood pressure in children and adolescents on kidney replacement therapy: 15 years of data from the ESPN/ERA Registry

Background Hypertension (HTN) is a well-known complication among patients on pediatric kidney replacement therapy (KRT). We aimed to evaluate demographics, longitudinal changes and outcomes of high blood pressure (BP) among children and adolescents on KRT. Methods Data on BP and antihypertensive (AH...

Intractable dialysis-associated headache: a management dilemma in pediatric hemodialysis
03/28/2026

Intractable dialysis-associated headache: a management dilemma in pediatric hemodialysis

Dialysis-associated headache (DAH) is a common and recognized complication of chronic hemodialysis. We report a diagnostically challenging case of severe intradialytic headache in an adolescent with chronic kidney disease stage 5 and a history of ventriculoperitoneal shunt. A comprehensive evaluatio...

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