American Society of Pediatric Nephrology

10/11/2025

Unexpected Gaucher disease in a case of steroid-resistant nephrotic syndrome

Gaucher disease (GD), the most common lysosomal storage disorder worldwide, should be considered in children presenting with unexplained hepatosplenomegaly and cytopenia. Kidney involvement is rare, and nephrotic syndrome constitutes an uncommon complication. We describe a 15-month-old female, the f...

10/11/2025

Slight acceleration in podocyte mRNA loss in preterm-born children aged 3–5 years

Background The global survival rate of preterm infants has been progressively increasing. However, concerns regarding their long-term prognosis persist. This study aimed to investigate podocyte mRNA loss in 3–5-year-old full-term and preterm children to elucidate the role of podocyte depletion in ...

10/11/2025

Clinical and prognostic characteristics of renal hypodysplasia in children: insights from a 10-year single-center cohort

Background Renal hypodysplasia (RHD) is a common and severe form of congenital anomalies of the kidney and urinary tract (CAKUT), often leading to chronic kidney disease (CKD) in children. This study, leveraging a 10-year single-center cohort, aims to elucidate clinical and prognostic characteristic...

10/10/2025

Computational Characterization of Lymphocyte Topology on Whole Slide Images of Glomerular Diseases

osclerosis, N=178 minimal change disease) with available clinical/demographic data and 1 Hematoxylin & Eosin-stained whole slide image were included. Cortex and lymphocytes were automatically segmented. A novel graph-based clustering algorithm was applied to identify dense versus sparse lymphocytic....

10/10/2025

Urinary biomarkers of acute kidney injury in neonates < 25 weeks’ gestation: a pilot study

Background Acute kidney injury (AKI) occurs in 30% of premature neonates and is associated with adverse outcomes that may be mitigated with early detection. Diagnosis of AKI relies on serum creatinine (SCr) which has several limitations, including lack of sensitivity and specificity. There are limit...

10/10/2025

Pathomechanisms of Antinephrin Antibody–Mediated Podocytopathy

An abstract is unavailable.

10/10/2025

Comparative efficacy of alteplase and urokinase in pharmacomechanical thrombolysis of permanent double lumen hemodialysis catheters in children

Background Thrombotic occlusion of permanent double lumen catheters (PDLC) in hemodialysis has traditionally been treated with urokinase (UK), a thrombolytic agent. However, because UK is no longer available, alteplase has been reported as an alternative. In this study, we compared the efficacy and....

10/09/2025

Dual role of FHR-1 in IgA nephropathy kidney injury
https://ow.ly/peEg50X8XNM

10/09/2025

Immunosuppression-Free Kidney Transplantation after Haploidentical HSCT in Fanconi Anemia (case report)
https://ow.ly/4ky850X8XLx

10/09/2025

The relationship between obesity and chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

https://ow.ly/bWOv50X8XIt

10/09/2025

Commentary/Review: PAX2-associated kidney dysplasia and podocyte injury: two faces of a monogenic disorder

https://ow.ly/fs7q50X8XXB

10/06/2025

Review: Defining Disease Modification in IgA Nephropathy: Toward a Paradigm Shift in Management