American Society of Pediatric Nephrology

09/01/2025

Overweight and Obesity in Pediatric Kidney Transplant Recipients Are Not Associated With Higher Risks of Early Postoperative Complications

Overweight and obese pediatric kidney transplant recipients experienced similar postoperative outcomes compared to normal-weight patients. These findings suggest that elevated body weight alone shoul...

08/31/2025

Shear wave elastography for assessing kidneys in pediatric patients with primary nephrotic syndrome

Objective Primary nephrotic syndrome (PNS) is a prevalent kidney disorder in pediatric patients, characterized by significant proteinuria, hypoalbuminemia, and edema, which poses serious health risks and economic burdens due to frequent relapses and hospitalizations. This study aims to explore the u...

08/31/2025

Landscape of subclinical rejection in a large international cohort of pediatric kidney transplant (kTx) recipients

Kidney allograft rejection occurs in clinically stable patients, but its long-term significance in children is unknown. Previous studies demonstrated that subclinical inflammation is associated with an increased risk of rejection. However, the prevalence and significance of subclinical antibody-medi...

08/30/2025

Review: Comparison of Three Different Staging Systems Capable of Predicting the Severity of Congenital Lower Urinary Tract Obstruction (LUTO) and Its Prognosis

The Ruano's proposed prenatal staging system for LUTO seems to offer a more comprehensive stratification of different severities of fetal LUTO as well as a guidance for potential prenatal therapy bas...

08/30/2025

Novel COL4A3–COL4A5 variants and digenic inheritance in pediatric Alport syndrome from Southwestern China

Alport syndrome is a hereditary glomerular disease driven by pathogenic variants in COL4A3–COL4A5 that compromise the α3–α4–α5 type IV collagen scaffold, manifesting as persistent hematuria, proteinuria, and ultimately end-stage renal disease. Its pronounced phenotypic variability, low sens...

08/29/2025

Projected hospitalization cost impact of the selective cytopheretic device in pediatric acute kidney injury

The Selective Cytopheretic Device for Pediatrics (SCD-PED) is a cell-directed extracorporeal therapy approved by the Food and Drug Administration through the humanitarian device exemption pathway f...

08/29/2025

Attribute-Based Medicine for IgA Nephropathy: Risk Factor Constellations Influence Kidney Prognosis

AbstractBackground and Hypothesis. Attribute-based medicine emphasizes tailoring care to patient-specific characteristics. IgA nephropathy (IgAN), a hetero

08/29/2025

New from ASPN!
🎙️ The Bean Pod — a short-form pediatric nephrology podcast created by the Clinical Affairs Committee.

Ep. 1: Prenatal consults in CAKUT with Dr. Keia Sanderson. Practical pearls in

08/29/2025

Predicting mortality and short-term outcomes of continuous kidney replacement therapies in neonates and infants

AbstractBackground. Continuous kidney replacement therapy (CKRT) has emerged as a valuable treatment option in critically ill neonates and infants with acu

08/29/2025

CAKUT subtypes determine the rate of progression to kidney failure – an adult patient cohort study

AbstractBackground and Hypothesis. Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are the leading cause of pediatric kidney failure (KF) and

08/28/2025

Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions

The inflammatory phenotype of acute kidney injury (AKI), characterized by interstitial infiltration of immune cells, arises due to nephrotoxic agents. However, it does not pose the same risk of occurrence and progression for everyone, suggesting that the amplification or attenuation of disease depen...

08/28/2025

The Coming of Age for Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) leads to cyst formation and interstitial fibrosis in the kidney with limited therapeutic options. A recent study demonstrates that Polycystic Kidney Disease is characterized by the presence of senescence in the affected epithelial cells. This ADPK...