Direct Primary Care Mebane

10/19/2025

PCOS is characterized by metabolic dysfunction. ovulatory disturbance, and hyperandrogenism. Main stream providers treat this condition with Metformin and birth control pills. Many of these patients have a genetic issue called MTHFR C677T. This enzyme is critical for how your body uses folate which is needed in the methylation cycle for healing, detox and DNA/RNA syntheses. Metformin and birth control decrease folate levels and methylation in the body. If a patient with PCOS already has a decrease in folate due to this genetic issue and they are given metformin and birth control this decreases their bodies ability to use folate even more leading to more disease and illness. These patients need to work with a functional provider to work on the root of illness not prescribed medications that make them worse.

10/11/2025

Direct Primary Care Mebane is hiring. We will consider a full time CMA, nurse or receptionist. If you are interested please email your resume to DirectPrimaryCareMebane@gmail.com.

Send a message to learn more

09/21/2025

Conventional providers do not think women need testosterone but there are many benefits of testosterone for women which is why we are supposed to produce it.

Mood & Mental Health

Mood Regulation: Adequate testosterone levels are associated with better mood stability and lower rates of depression or anxiety.

Confidence and Drive: It can improve motivation, assertiveness, and overall sense of well-being.

Sexual Health

Libido: Testosterone supports healthy s*xual desire and arousal.

Vaginal Health: Supports vaginal tissue health, helping with lubrication and reducing discomfort during s*x.

Energy & Vitality

Fatigue Reduction: Low testosterone can cause fatigue; restoring levels may boost energy.

Improved Resilience: May help with mental and physical endurance.

Muscle Mass & Strength

Lean Muscle Maintenance: Supports muscle development and helps prevent muscle loss, especially post-menopause.

Improved Physical Performance: May increase strength, endurance, and recovery from exercise.

Bone Health

Bone Density: Works in synergy with estrogen to maintain bone strength and reduce risk of osteoporosis.

Cognitive Function

Memory and Focus: Some evidence suggests testosterone may aid in memory, focus, and cognitive sharpness.

09/19/2025

We have an open part time position for a CMA or nurse. If you are interested, please email your resume to directprimarycaremebane@gmail.com

07/06/2025

Due to flooding in our area the office will be closed tomorrow.

06/11/2025

The office will be closed on June13th and 16th.

05/28/2025

When trying to lose weight the goal is to do it in a healthy way. I have heard of places that tell patients to decrease calories to 700-800 calories per day. This is not sustainable. It also slows metabolism and thyroid function. This will lead to more weight gain once you come off of the diet/weight loss medicine.

If you are taking a GLP medication and decreasing calories to these levels you can lose muscle mass. A loss of muscle mass also slows down metabolism.

The goal should be eating healthy whole foods and exercising while focusing on reasons you may not be losing weight such as imbalances in your body.

If you choose to add a GLP medication make sure you are still getting enough calories and protein.

04/04/2025

Yale published about post vaccine syndrome. The publication discuss symptoms such as brain fog and fatigue but also states "From participants’ blood samples, the researchers looked for immune features that were different between the two groups. They found several differences in immune cell populations; those with PVS had lower levels of effector CD4+ T cells and higher levels of TNF-alpha+ CD8 T cells — both are types of white blood cells — among other differences."

https://news.yale.edu/2025/02/19/immune-markers-post-vaccination-syndrome-indicate-future-research-directions

Lower levels of effector CD4+ T cells and higher levels of TNF-alpha+ CD8 T cells (both types of white blood cells) can indeed increase the risk of cancer, as they can disrupt the cancer-immunity cycle and impair the body's ability to effectively fight tumors.

https://www.sciencedirect.com/science/article/pii/S1074761323004107 #:~:text=CD4+%20T%20cells%20can%20have,the%20CD4+%20T%20cell%20compartment.

If you are experiencing these symptoms or concerns please reach out for a free Meet and Greet through our website at directprimarycaremebane.com

04/04/2025

Long COVID is debilitating and difficult to treat because it is a complex illness.

Studies show it can cause thyroid dysfunction, vitamin deficiencies, gut health imbalances, mitochondrial deficiencies, adrenal gland problems, elevated estrogen and can be more prevalent in people with an MTHFR gene mutation.

All of these plus toxins need to be evaluated and treated in patients with Long COVID.

If you have been told you have Long COVID and are interested in getting advanced testing and treatment please schedule a Free Meet and Greet through our website at

Visit Direct Primary Care Mebane Visit Direct Functional Medicine Affordable Care That Isn't Rushed Offices in Greensboro and Mebane. Visit Direct Primary Care Mebane Affordable Care That Isn't Rushed Visit Direct Functional Medicine A Virtual and In Person Functional Medicine Clinic for all of Nort...

03/08/2025

Leptin is a hormone made by fat cells to keep food intake and weight balanced. It is released by the brain to control the sensation of feeling full. Leptin resistance can alter metabolism and makes people feel hungry and eat more. There are several causes for leptin resistance, including chronic inflammation, stress, leaky gut, gut bacteria overgrowth or gut microbiome imbalance, nutrient deficiencies, and toxins. If you think you may be struggling with Leptin resistance please schedule a free Meet and Greet at

Visit Direct Primary Care Mebane Visit Direct Functional Medicine Affordable Care That Isn't Rushed Offices in Greensboro and Mebane. Visit Direct Primary Care Mebane Affordable Care That Isn't Rushed Visit Direct Functional Medicine A Virtual and In Person Functional Medicine Clinic for all of Nort...

03/06/2025

A sign of vitamin D deficiency is binge eating. Impaired satiety and the tendency to overeat are often seen in people who have low vitamin D levels.

Low vitamin D also leads to weight gain because your metabolism slows down.

03/04/2025

Almost every patient I have tested for mold is positive for ochratoxin A (OTA) which is a very toxic strain of mycotoxin. A colleague of mine who has practiced Integrative oncology for 30 years has found it in almost all of his cancer patients. A study published in 2024 found a strong correlation between OTA and renal cell carcinoma (RCC), with potential associations with other malignancies, including hepatocellular carcinoma (HCC), gallbladder cancer (GBC), and squamous cell carcinoma (SCC). In North Carolina mold is found in at least 25% of homes, which includes new builds. Please reach out for a free Meet and Greet if you think you may have been exposed to mold. It lives in the body for years after exposure.

Background: Ochratoxin A (OTA) is widely recognized for its broad spectrum of toxic effects and is classified as a potential human carcinogen, placed in group 2B by the International Agency for Research on Cancer (IARC). Its presence in food and beverages poses a significant health hazard. Extensive...