
09/23/2025
Exactly my thoughts. đ
HHS just dropped a bombshell recommendation: Skip Tylenol (acetaminophen) for pregnant women and young children, fueled by groundbreaking 2025 studies from Mount Sinai and Harvard. Letâs unpack this with nuanceâbecause autism is a SPECTRUM for a reason: a perfect storm of genetic, epigenetic, and environmental factors weaving together in bio-individual ways.
Harvardâs T.H. Chan meta-analysis pooled 10+ global studies (>300,000 pregnancies), it flagged 15-25% higher ASD/ADHD risks with prenatal use (>2x/week), strongest in trimester 3. Limits Self-reported data adds recall bias, and associations fade with tighter controlsâno clear dose-response.
These spotlight neuroinflammationâa thread in the autism tapestry. Other research looks at genetic methylation variants (e.g., MTHFR polymorphisms disrupting detox pathways) and how they amplify environmental hits like acetaminophen, sparking oxidative stress and brain wiring glitches.
MY Take: Itâs not one thing; itâs the perfect stormâgenes load the gun, epigenetics pull the trigger. To be clear: talking about profound autism with co-occurring conditions (e.g., GI issues, seizures, immune dysregulation), where these inflammatory cascades roar loudest. Neuro-diversity is a separate topic and completely normal and should be celebrated. Neuro-inflammation is not the same as neurodiversity. Letâs quit lumping every person in one group. Autism and co-occurring conditions isnât a monolithâitâs a mosaic of strengths and challenges.
From my vantage over 15 years and thousands of global telehealth patients: Neuro-inflammatory & autoimmune threads weave through nearly every case. Yet, what ignites it in one (say, a methylation snag + toxin load) might not impact another. Bio-individuality reignsâyour microbiome, stressors, nutrigenomics all play. Itâs not about âcuringâ but OPTIMIZING.
đ§ learn more : https://drwillcole.com/functional-medicine-approach-to-autism/