Nikon Microscope Solutions

09/03/2025

📄 🌈 Researchers from Fudan University introduce the lanthanide rainbow – a palette of based on erbium(III)-phthalocyanine complexes that can be engineered with tunable near-infrared absorption and common 1530 nm emission.

🔬 Lanbow fluorophores have high brightness and excitation maxima ranging from 673 – 772 nm, within the optical window of biology. The authors demonstrate their application for excitation-encoded 9-plex imaging in a tissue phantom and 5-plex of the gastrointestinal tract of a mouse colorectal cancer model (figure).

🔗 View the article here: https://go.nature.com/4g9pWoA

09/02/2025

🔬 Our AX / AX R with detector supports near-infrared !

🖼️ Check out this comparison of a HeLa cell imaged with the NSPARC (left) and a standard confocal detector (right). The cell is labeled for DNA (DAPI; blue), actin (Alexa Fluor 488; green), microtubules (Alexa Fluor 568; yellow), and mitochondria (Alexa Fluor 750; red).

🔗 Learn more here: https://bit.ly/4p4izCV

09/01/2025

🤔 How easy is it to use our ECLIPSE Ji Smart Imaging System?

🌐 Our website includes an interactive tutorial exploring the basic operation of the Ji for a sample assay using a well plate.

🔬 The Ji is a reliable solution that provides the power of a research in the form of a user-friendly benchtop assay instrument.

🔗 Click to try it out: https://bit.ly/3UUWyZu

08/29/2025

🔬 techniques have greatly expanded the types of questions that can be addressed using the optical microscope, but can be more challenging to reliably implement.

🧑‍🔬 The has the expertise to make your super-resolution imaging experiments successful using the following techniques:

⚡ using our AX R with detector - a robust solution that can improve resolution by a factor of ~2X, even in live samples.

⚡ Single molecule localization microscopy using the N-STORM system, supporting up to ~10X higher resolution in fixed samples.

🔗 Contact us about this or our other services: https://bit.ly/4mEVwx5

🖼️ Image is courtesy of Dr. David Zhi-Zhou He of Creighton University and shows a whole mount of inner ear cells, where individual cilia (~100 nm in width) are well resolved using the AX R with NSPARC.

08/28/2025

🔬 What kind of difference can the CrestOptics X-Light V3 or DeepSIM system make for your imaging?

🧠 This image compares the performance of widefield (left), the X-Light V3 (center), and DeepSIM (right) for imaging of Thy1-GFP expressing neurons in a mouse hippocampal coronal section.

🔗 Learn more about these systems: https://bit.ly/45ES6UX

08/27/2025

🔬 Smart , also known as , refers to automated imaging approaches that rely on real-time analysis of image data to guide the course of the experiment – revolutionizing imaging workflows.

📄 A new preprint from scientists brought together by the Smart Microscopy Working Group of Euro-BioImaging provides a survey of the current state of this field, discusses various organizational and technical challenges, and provides examples of how feedback microscopy is applied.

🦠 👀 A common example of a feedback microscopy experiment is low-intensity monitoring of live cell populations for mitotic cells, which are automatically identified and then imaged in greater detail.

🔗 Click to view the preprint: https://bit.ly/3UOMW2j

✨ Nikon has deep expertise in designing feedback microscopy experiments using our unified NIS-Elements software with JOBS module. Advanced functionality for tasks such as denoising and image segmentation can also be integrated using available NIS_ai modules. NIS-Elements supports the use of custom Python scripts in feedback microscopy experiments.

08/27/2025

08/26/2025

📜 Learn the history of as told by Uli Koch, likely the most passionate and knowledgeable collector of Nikon microscopes in the world.

📹 This featured article includes a video interview where Uli provides a fascinating perspective on the development of the Nikon business and the early evolution of our product line: https://bit.ly/479zk9j

🔬 In celebration of the 100th anniversary of our microscope business, we unveiled MAGNIFIED – a special temporary exhibition at Micropia in Amsterdam for which Uli was generous enough to lend 8 microscopes (including a JOICO, our very first model): https://bit.ly/4oR8vNo

🙏 Thank you Uli!

Nikon Small World

08/25/2025

🔬✨ Our ECLIPSE Ji Smart Imaging System is powered by the NIS-Elements Smart Experiment software, which leverages for operational efficiency and includes a variety of turnkey assay experiments.

📹 In this short video, Kohma Hayashi of the Nikon Healthcare System Development Department shares his perspective regarding Smart Experiment.

🔗 Click to learn more about the Ji: https://bit.ly/4fPYXy5

08/22/2025

🖼️ Thank you to Moffitt Cancer Center for sharing this striking image of human prostate cancer microtissue, showing cell nuclei (blue), prostate-specific antigen (green), and the actin cytoskeleton (red).

🔬 Imaging was performed using a Nikon AX R with detector.

🔗 Learn about the Nikon Center of Excellence at Moffitt Cancer Center here: https://bit.ly/3HnEnIU

08/21/2025

🔬 ICYMI, the ECLIPSE Ti2-I motorized inverted for and is now available in the US!

🔘 The Ti2-I assigns key observation mode settings for the lab to dedicated buttons, reducing the number of manual microscope operations by ~75%.

🟥 🟦 Spindle observation mode is a polarized light technique that renders the oocyte spindle in vivid color, regardless of their orientation. With the push of a button, you can switch between Spindle observation and other modes.

🔗 Click to learn more about how the Ti2-I can simplify your workflow: https://bit.ly/4lJEn3Z

08/20/2025

✨ 🔬 What happens when large language models meet ?

📄 A preprint article from researchers at the Harbin Institute of Technology introduce the Embodied Intelligent Microscope System (EIMS), which uses a large model to design an automated experiment based on both complex user input and the real-world capabilities of the .

🖼️ The authors demonstrate EIMS for several applications, including autonomous transfer of into patterned arrays using robotic micromanipulators.

🔗 Click to view the preprint article: https://bit.ly/4mAAEqz