SwitchGear Genomics

08/01/2012

http://www.prweb.com/releases/2012/7/prweb9724250.htm

SwitchGear Genomics has launched a new service group to offer custom cloning and mutagenesis in the LightSwitch Vector system to complement SwitchGear’s genome-wide collection of human promoter and 3’UTR reporters

07/19/2012

July 2012 newsletter: Grant highlight and new publication on reovirus as an anti-miRNA therapy

Dr. Stephanie Murphy is an Associate Professor of Anesthesiology and Perioperative Medicine at Oregon Health and Science University. She focuses on the role of gender and female s*x steroids in perioperative stroke risk. Stroke occurs more frequently in men than women, and ischemic sensitivity of ro...

06/21/2012

http://createsend.com/t/r-DF16D99D93A9B1F5

This month's grant winner highlight from our grant awards program is Dr. George Yousef, Principal Investigator at St. Michael’s Hospital in Toronto. Dr. Yousef reported miRNA dysregulation in kidney cancer (RCC) and provided evidence for miRNA involvement in RCC pathogenesis. Dysregulated miRNAs are...

05/23/2012

http://createsend.com/t/r-370796BC5A4FB5AF

This month's grant winner highlight from our grant awards program is David Mu, Ph.D., Associate Professor at the Penn State University College of Medicine. Dr. Mu is interested in understanding the roles of the microRNA network in the biology of the lung. His lab used an essential lung developmental...

04/20/2012

http://createsend.com/t/r-2015BC074EF92D00

This month's grant winner highlight from our grant awards program is Seth Masters, Ph.D., Lab Head at the Trinity College in Dublin. The lab is focused on inflammation, specifically innate immune pathways that are triggered during infection or chronic disease to make inflammatory cytokines. They ide...

03/19/2012

March 2012 newsletter with grant winner highlight
http://createsend.com/t/r-E13FCAA1C8FF5712

This month's grant winner highlight from our grant awards program is Kimberley Cordes, Ph.D., Postdoctoral Fellow at the Gladstone Institute of Cardiovascular Disease. Dr. Cordes is studying the mechanisms that regulate vascular smooth muscle proliferation, a hallmark of atherosclerosis. She identif...

02/09/2012

Check our grant winners from our recent miRNA target validation grant program

FGF19 (mouse ortholog FGF15) is a target gene of nuclear receptor FXR. FGF19 has been shown to play a role in liver proliferation and regeneration, and may be involved in liver hepatocellular carcinoma (HCC). miR-21 is overexpressed in most human cancers and overexpession can induce cancer in mice. ...

01/26/2012

January 2012 newsletter

The function of TR3, a nuclear receptor that is overexpressed in most lung cancers, was investigated in this study. Knockdown of TR3 by RNA interference inhibited cancer cell growth and induced apoptosis. In part by using SwitchGear’s promoter GoClone reporters, the researchers found that he prosurv...

12/14/2011

SwitchGear Genomics Launches Bioassay Kits for Environmental Toxicology Market

LightSwitch Reporter Assay System delivers the next generation of environmental toxicology screening strategies

12/08/2011

SwitchGear Genomics launches the largest collection of transcription factor response element reporter vectors

SwitchGear offers 91 Response Element Reporters for well-studied pathways to LightSwitch product line in addition to collection of 18,000 endogenous human promoter GoClone reporters.

11/01/2011

November newsletter: check out our grant program!

10/01/2011

See our new video protocol published in the Journal of Visualized Experiments

MicroRNAs (miRNAs) are important regulators of gene expression and have been shown to play a role in numerous biological processes. To better understand miRNA-UTR interactions, we have created a genome-wide collection of 3 UTR luciferase reporters paired with a novel luciferase gene and assay reage...

09/14/2011

Join us on LinkedIn!

Welcome to the company profile of SwitchGear Genomics on LinkedIn. SwitchGear Genomics Inc. is a leading provider of products for studying the regulatory elements in...

09/07/2011

September 2011 newsletter

The researchers in this study analyzed the expression of 365 miRNAs in human colonic epithelial cells followed by the activation of the neurotensin receptor NTR1 which known to play a role in inflammation and colon cancer. Using a combination of microarray analysis, soft agar assays, xenograft analy...

08/09/2011

August 2011 Newsletter

The absence of RNA virus-encoded miRNAs had previously led to the assumption that miRNA processing occurs only in DNA-based organisms. The researchers in this study tested this assumption by engineering both a cytoplasmic and nuclear RNA virus that produced a fully functional miR-124 without the los...

07/21/2011

Check out our new loyalty rewards program!

Please fill out the form to sign up for the loyalty program. Click here to see rewards.Once you register, we will send you an email on the details of participating in our loyalty rewards program!

06/30/2011

July 2011 Newsletter

The variability of malaria symptoms among individuals may be partly due to heritable differences in susceptibility to the disease. Specifically, the FAS gene encodes the cell surface receptor CD95, which has been implicated at higher levels in severe malarial infections. To further functionally char

05/18/2011

New publication utilizing our 3'UTR reporter assays

*Correspondence: Clifford J. Steer, Department of Medicine, University of Minnesota Medical School, MMC 36, VFW Cancer Research Center, Room V357, 406 Harvard Street S.E., Minneapolis, MN 55455