06/12/2025
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The study referenced here concluded that creatine can help at least partially reverse some of the metabolic changes and cognitive deterioration of sleep deprivation, which is certainly a unique finding.
However, the largest issue for me is that the study only involved a small number of patients (15). For sure, larger studies with greater numbers of patients would be needed to draw more definitive conclusions. I definitely would like to see this replicated independently.
That being said, the findings in this study do seem to support the findings of other recent studies that creatine may help support cognitive function. Again though, larger studies and with greater numbers of patients are necessary here before making more definitive conclusions on the matter.
On a more positive note, even though it was a small study, it was a randomized controlled trial, which is our highest level of evidence. Additionally, it was pretty well designed and the results were statistically significant (p values < 0.05).
If you would like to check out the study, the PMID is 38418482.
And if you are familiar with the study and have any critiques of it, feel free to share your thoughts on it in the comments. What do you think is its biggest flaw?
