Dr. Rudy Best Life, 9655 S. Dixie Highway, Suite 310, Miami, FL (2025)

09/24/2025

🚨 Not everyone should jump on the longevity bandwagon.

Rapamycin, Metformin, and NAD+ are some of the most talked-about tools in anti-aging medicine — but here’s the truth: they’re not meant for everyone.

🔹 Rapamycin → Best studied in older adults or those with higher risks of immune aging. At high doses, it can suppress immunity, so it’s not for young, healthy individuals or people with active infections or cancer.
🔹 Metformin → Fantastic for people with type 2 diabetes or insulin resistance, and possibly protective in people at higher metabolic risk. But if you’re lean, insulin-sensitive, and under 40? The benefits aren’t as clear.
🔹 NAD+ → Probably the most flexible of the three. It can help boost energy and repair even in middle-aged, healthy individuals. But the “optimal dose” still varies by genetics and health status.

✨ Longevity medicine isn’t one-size-fits-all. These tools can be powerful — but only when matched to the right person at the right stage of life.

👉 That’s why working with a physician who understands both the science and your biology is key.

Follow for science-backed longevity strategies that cut through the hype and help you build more healthy years.

📖 Research Sources
https://loom.ly/DhdrGlI
https://loom.ly/gzce7h4
https://doi.org/10.1016/j.tibs.2013.09.003

09/22/2025

🧠✨ What if I told you your brain can still grow at 40, 60, or even 80 years old?

That’s the magic of neuroplasticity — your brain’s ability to rewire and form new pathways throughout life. For decades, scientists thought brain cells only declined with age. Now we know that’s not true.

Every time you learn a skill, challenge your memory, or move your body, you’re literally reshaping your brain. The connections between neurons strengthen, new ones are built, and your brain adapts. This isn’t just about boosting memory — it’s how you protect yourself from cognitive decline and stay mentally sharp well into older age.

Here’s the kicker: unlike most of your organs, the brain has this unique superpower. Your kidneys, heart, and lungs can’t rebuild themselves the way your brain can when it’s stimulated. That’s why investing in brain health is the most important form of longevity medicine.

✨ If you want to age better, start with your brain.

👉 Follow for science-backed strategies to keep your brain and body young.

https://doi.org/10.1044/1092-4388(2008/018)

09/20/2025

🤖 Imagine if a computer could predict how fast you’re aging, and help slow it down.

That’s not science fiction anymore. AI is starting to transform longevity medicine in ways we couldn’t imagine a decade ago.

Instead of waiting years for drug trials, AI can now analyze billions of molecules in weeks. That’s how researchers are finding new longevity compounds at record speed. Even more fascinating, AI can look at your labs, DNA, and wearables to calculate your “biological age”, the age your body is really acting like, which often tells a very different story than your birthday candles.

And here’s where it gets powerful: AI doesn’t just crunch numbers. It can design personalized nutrition, exercise, and hormone protocols that fit your biology, no more guessing or one-size-fits-all advice.

But don’t get it twisted: AI isn’t a replacement for the basics. Without sleep, movement, and proper nutrition, even the smartest algorithms can’t keep you healthy. The future of longevity isn’t AI or lifestyle… it’s AI + YOU.

✨ Follow for science-backed insights on longevity, biohacking, and healthspan strategies that cut through the hype.

https://doi.org/10.1021/acs.molpharmaceut.8b00930

09/18/2025

⚡ Can you “dose” energy?

That’s the big question with NAD+, the molecule your cells use to make ATP — aka the fuel for everything from brainpower to muscle recovery.

Here’s what we know: NAD+ levels decline with age, and that drop is linked to fatigue, slower repair, and higher risk of chronic disease. Supplementing NAD+ can restore cellular energy and improve resilience — but the debate is around how much, how often, and in what form.

💉 IV infusions deliver rapid spikes but can feel uncomfortable for some patients.
💊 Oral precursors (like NMN) are convenient but less bioavailable.
💉 Subcutaneous microdosing (50–100 mg several times per week) is showing promise for steady benefits without the crash.

There isn’t a single “optimal” dose for everyone — genetics, lifestyle, and health status all play a role. But what’s exciting is that doctors and scientists are moving toward personalized NAD+ protocols instead of one-size-fits-all.

✨ Think of it less like a magic bullet and more like tuning your body’s energy dial.

👉 Follow for science-backed strategies on longevity, hormones, and healthspan.

📖 https://doi.org/10.1016/j.tibs.2013.09.003

09/16/2025

🔺 Here’s the mistake I see most people make when it comes to longevity…

They jump straight into the shiny stuff, biohacks, supplements, even advanced drugs, thinking that’s the secret to living longer. But the truth? Without the fundamentals in place, none of those things will work the way you hope.

Think of your health like a triangle:
- If the base (food, sleep, exercise) is shaky, the top will always collapse.
- If your mindset and hormones are out of balance, stress will drain you faster than any molecule can save you.
- Only once the bottom is solid does the peak, the advanced tool, actually add value.

Longevity isn’t about collecting hacks. It’s about sequencing your health in the right order. That’s the real unlock.

✨ Follow to learn how to build health that actually lasts, from the foundation up. No fads, just science and experience.

09/15/2025

Repetition is the key to transformation 🔑

I repeat myself because the fundamentals never change:
🥗 Eat clean
💤 Sleep deeply
🏋️‍♂️ Move daily

Without these, nothing else works.

🎧 Listen to the full episode here: https://loom.ly/4PzRJ10

09/14/2025

🚀 We used to think aging was inevitable… now we’re testing ways to slow it down.

In longevity research, three tools stand out: Rapamycin, Metformin, and NAD+. None of them are magic pills — but each one shows promising evidence of extending healthspan (the years you live well).

🔹 Rapamycin — Discovered in soil on Easter Island, this mTOR inhibitor slows down cellular “overdrive.” In animal studies, it consistently extends lifespan.
🔹 Metformin — The classic diabetes drug with surprising side benefits. Beyond blood sugar, it activates autophagy (your body’s cleanup process) and may protect against chronic disease.
🔹 NAD+ — Your cell’s fuel for making energy. Levels drop with age, but replenishing NAD+ may boost repair, brain health, and resilience.

👉 The real story? These aren’t silver bullets. But when studied carefully, and stacked on top of lifestyle (nutrition, exercise, sleep, mindset), they could reshape what it means to grow old.

✨ We’re not chasing immortality. We’re chasing more vibrant, functional years.

Follow for science-backed longevity tools explained.

📖 Research Sources
https://loom.ly/DhdrGlI
https://loom.ly/gzce7h4
https://doi.org/10.1016/j.tibs.2013.09.003

09/13/2025

Not every “longevity hack” belongs in your routine 🚦

Some anti-aging tools are OTC while others require prescription and expert guidance.
Partner with a longevity specialist, not just any doctor, to find what is truly right for you.

🎧 Listen to the full episode here: https://loom.ly/4PzRJ10

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09/12/2025

⚡️ Ever wonder why your energy feels limitless at 20… but harder to find at 40? 👀

The secret might be NAD+. Think of it as your body’s “cellular fuel manager.” It helps your mitochondria — your tiny energy factories — turn food into usable energy. Without it, you don’t just feel tired… every process in your body slows down.

Here’s what’s wild: NAD+ levels naturally decline with age. That drop is linked to fatigue, slower recovery, brain fog, and even accelerated aging. It’s one reason you may feel like your body isn’t keeping up the way it used to.

But there’s hope: studies show exercise, intermittent fasting, and quality sleep can boost NAD+ activity. Researchers are also exploring supplements like NMN and NR as potential ways to restore youthful NAD+ levels — though the science is still unfolding.

This isn’t just a “longevity trend.” NAD+ is at the center of one of the most exciting areas in anti-aging medicine. Supporting it may be key to better energy, sharper cognition, and a longer healthspan.

👉 If you’re serious about living not just longer, but better, follow for science-based strategies.

https://doi.org/10.1038/ncomms12948

09/10/2025

💊 Imagine if one of the most promising “longevity drugs” was already sitting in your neighborhood pharmacy… and costs less than a cup of coffee.

Metformin has been used for decades to treat type 2 diabetes. But here’s the twist: researchers noticed something unusual — patients on Metformin often lived longer than expected. Not just because of better blood sugar… but because of something deeper happening at the cellular level.

Think of it like this 👉 your cells are tiny factories. Over time, waste builds up, machinery slows down, and mistakes pile up. Metformin seems to help these factories “clean house,” making them run more efficiently and protecting them from wear and tear.

That’s why scientists are now exploring whether Metformin could do more than manage diabetes. Could it extend healthspan — the years you live with strength, clarity, and vitality? The massive TAME trial is underway to find out.

⚠️ Of course, it’s not without risks (GI upset and low vitamin B12 are common), and it’s not a replacement for the basics: nutrition, exercise, sleep, and stress management.

But the big idea is this: sometimes the most exciting discoveries in longevity don’t come from futuristic tech — they come from looking at old tools in new ways.

✨ Follow if you want science made simple

https://doi.org/10.1111/dom.12354

09/09/2025

Found rapamycin online and want real answers

Bring me the clip. I will explain it, check your labs, and build a plan that fits your life. Partnership medicine, simple and safe.
🎧 Listen here: https://loom.ly/4PzRJ10

09/08/2025

💊🌴 What if the secret to aging slower was hiding in the soil of a remote island?

Rapamycin might sound like science fiction, but it’s one of the most intriguing discoveries in longevity research. Originally found in the dirt of Easter Island (Rapa Nui), it was first used to prevent organ rejection in transplant patients. Decades later, scientists realized it does something even bigger: it slows down a cellular pathway called mTOR — the same pathway that drives unchecked cell growth and aging.

Here’s what makes it exciting:
⚡ In animal studies, Rapamycin consistently extended lifespan.
⚡ In humans, early trials show signs of healthier immune function and possibly slower biological aging.
⚡ It’s now at the center of the “longevity cocktail” many researchers are exploring.

But let’s be real — Rapamycin isn’t a magic bullet. It can suppress the immune system if used incorrectly, and research is still ongoing. The key is context: this drug only makes sense when paired with the fundamentals of health — nutrition, exercise, sleep, hormones, and stress balance.

As a doctor, I believe the future of aging isn’t about living longer at any cost — it’s about living better for longer.

✨ Curious about science-based ways to extend your healthspan? Follow me for real strategies that go beyond hype.

📖 https://doi.org/10.1038/nature08221

Dr. Rudy Best Life

09/24/2025

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