09/24/2025
A study comparing Rhodiola rosea to the antidepressant sertraline (Zoloft) found that both reduced depression symptoms, but Rhodiola was better tolerated and produced fewer side effects.
The study was a double-blind, randomized, placebo-controlled trial, meaning participants were randomly assigned to receive either Rhodiola rosea, sertraline, or a placebo, and neither the participants nor the researchers knew who was receiving which treatment until the end.
Both Rhodiola rosea and sertraline showed improvements in depression symptoms and while sertraline had a slightly greater effect, Rhodiola was more favorable in terms of risk-to-benefit ratio, particularly for mild to moderate depression.
Another positive in choosing Rhodiola over a prescription antidepressant is that Rhodiola is an adaptogenic herb that works to heal your body from stress related hormone imbalances and other health issues, returning the body to homeostasis. This means Rhodiola could provide relief from the depression while possibly healing you for good by returning you to homeostasis and perfect hormone balance.
You can find the only Rhodiola I use, love and trust in the links in my bio!
Please always research before starting any new herbs especially if you are pregnant, nursing, on any prescription medication or have any diagnosed medical condition. It is not advisable to mix Rhodiola with an antidepressant. You must take one or the other.
PMID: 35745023