08/12/2025
A woman with a rare genetic mutation, identified as Jo Cameron, was discovered to have a unique condition that prevents her from feeling pain, experiencing anxiety, and developing scars after injuries.
This extraordinary case was studied by scientists, particularly at University College London, who linked her condition to mutations in the FAAH and FAAH-OUT genes. These genes regulate the endocannabinoid system, which modulates pain, mood, and healing.
The FAAH-OUT mutation, a previously unidentified pseudogene, significantly reduces FAAH enzyme activity, leading to elevated anandamide levels—a neurotransmitter associated with pain suppression and mood regulation.
As a result, Cameron experiences no physical pain, even during severe injuries or childbirth, and reports consistently high mood stability, with no anxiety or depression.
Her wounds heal rapidly without scarring, a phenomenon tied to altered inflammatory responses. This discovery, detailed in a 2019 study published in "The British Journal of Anaesthesia", offers insights into pain management and mental health treatments.
Researchers aim to replicate these effects pharmacologically, potentially revolutionizing therapies for chronic pain and anxiety disorders.
Cameron’s case highlights the profound impact of genetic variations on human physiology and opens avenues for targeted medical interventions.
