03/03/2026
The Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, in partnership with the Cardiovascular Research Center (CVRC), has announced the recipients of its 2025/2026 Genomic Sciences & Precision Cardiovascular Medicine Award, along with this year’s jointly funded pilot research awards supporting innovative cardiovascular science.
The $75,000 Genomic Sciences & Precision Cardiovascular Medicine Award was awarded to a multidisciplinary team led by Aoy Tomita-Mitchell, PhD, professor of surgery (division of pediatric cardiothoracic surgery), and Angela Mathison, PhD, associate professor of surgery. Their project, “Precision Therapeutics for HLHS: Single-Cell Profiling and A*O Rescue of MYH6 E1584K,” aims to advance gene-targeted therapies for hypoplastic left heart syndrome (HLHS).
This award will support studies demonstrating that antisense oligonucleotides (A*Os) can correct the underlying genetic drivers of HLHS, rather than solely managing disease symptoms after onset. If successful, this approach has the potential to reduce complications, shorten hospital stays, and improve long-term outcomes for children with HLHS and their families. Importantly, the strategy may also be adaptable to other genetically driven forms of heart disease, further advancing pediatric cardiology toward precision medicine - delivering the right treatment to the right patient at the right time.
Designed to accelerate innovative, high-impact research, the Genomic Sciences & Precision Cardiovascular Medicine Award prioritizes emerging ‘omics-based methodologies that interrogate the molecular mechanisms of cardiovascular disease. The funding mechanism aims to catalyze future extramural grant submissions, publications, or both, while fostering cross-disciplinary collaboration and technological innovation.
In addition to the major award, the Mellowes Center and CVRC also funded pilot research projects totaling up to $40,000, supporting early-stage, high-risk ideas with strong potential for scientific and translational impact. 2025 Mellowes Center CVRC Pilot Award recipients include:
Brian Lin, PhD, assistant professor of cell biology, neurobiology, and anatomy, for his project “Mechanisms by Which TRPC6 Inhibitors Rescue Heart Failure Using Human Stem Cell Models of DMD.”
Brian Smith, PhD, associate professor of biochemistry, for his project “BET Proteins Influence Macrophages During Inflammation.”
These competitive pilot awards share the same overarching goal as the Genomic Sciences & Precision Cardiovascular Medicine Award: to generate impactful preliminary data that advances cardiovascular discovery, strengthens future funding applications, and promotes collaboration across disciplines and institutions.