11/26/2025
Reposting with key context:
Experimental mRNA flu vaccine shows superior efficacy against symptomatic illness
The vaccine was fully protective in a small human challenge model, showing superior efficacy to the conventional 4-strain flu vaccine
A human-challenge randomized controlled trial, published last week in NEJM Evidence, finds that an mRNA (modRNA) influenza vaccine is 100% effective against both symptomatic and febrile flu, compared with 85% and 100% with the conventional quadrivalent (four-strain) influenza vaccine (QIV).