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Monday 8am - 4:30pm Tuesday 8am - 4:30pm Wednesday 8am - 4:30pm Thursday 8am - 4:30pm Friday 8am - 4:30pm Saturday 8am - 4:30pm Sunday 8am - 4:30pm

The Lillehei Heart Institute

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The Lillehei Heart Institute

"What mankind can dream, research and technology can achieve." - C. Walton Lillehei

10/22/2025

LHI Lecture Oct. 29, noon:

“Risk Factors, Inflammation, and Cardiometabolic Disease in Humans: Insights across the Translational Spectrum”

Matthew Feinstein, M.D.
Thomas D. Spies Professor of Cardiometabolic Inflammation
Associate Professor of Medicine
Cardiology, Preventive Medicine (Epidemiology), and Pathology
Northwestern Medicine, Feinberg School of Medicine

More about Dr. Feinstein from the ORG website:
https://buff.ly/sBRVmvW

Location:
1-101 Microbiology Research Facility (MRF)
689 23rd Ave SE, Minneapolis, MN
Map: https://buff.ly/NUsALxS
Webcast @ z.umn.edu/lhi-webcast

Learning Objectives:
1. Discuss clinical trial evidence of targeting inflammation in human atherosclerotic cardiovascular disease.
2. Discuss clinical trial evidence of targeting metabolic inflammation in human heart failure.
3. Understand fundamental ways in which the immune system and cardiometabolic risk factors interact to result in excess, harmful inflammation versus resolution thereof.

10/21/2025

A groundbreaking new study published in the journal Molecular Therapy heralds a major step forward in treating muscular dystrophies. The research, led by LHI researcher Rita Perlingeiro, PhD, details a clinically-ready process to generate therapeutic cells for muscle regeneration.

Dr. Perlingeiro’s team successfully developed a current good manufacturing practice (cGMP) compliant protocol to create large-scale, cryopreserved PAX7-induced myogenic progenitors (MyoPAXon) from induced pluripotent stem cells (iPSCs). This is a critical development, as it addresses the scalability and safety requirements needed for human clinical trials.

The study, titled "Preclinical quality, safety, and efficacy of a cGMP iPSC-derived myogenic progenitor product for the treatment of muscular dystrophies," demonstrates that MyoPAXon can effectively reconstitute both new muscle fibers and muscle stem cells (satellite cells) in preclinical models. This robust regenerative capacity positions Dr. Perlingeiro's work as a pioneering effort toward the first-ever stem cell-based treatment for devastating muscle-wasting diseases.

10/17/2025

RSVP by OCTOBER 24 to join UMN Cardiology for Minnesota Night at ! Details @ buff.ly/91uJaTK.

10/09/2025

Congratulations to LHI Director, Dr. Lin Yee Chen and University of Washington collaborators (Drs. James Floyd and Will Longstreth) for their new NHLBI R01 grant: Proteomic and Genomic Discovery of Targets for Atrial Cardiopathy-Related Cardiovascular Outcomes, 9/2025 - 6/2029, $5.24M.

This project seeks to identify novel molecular targets to prevent cardiovascular outcomes in people with atrial cardiopathy.

10/06/2025

The van Berlo laboratory published in Circulation Research how the cytoskeletal protein Septin4 regulates the development of cardiac fibrosis through modulation of calcineurin activity. Read the full article: https://buff.ly/EUNsdKG

09/23/2025

Mark your calendars! The Fall 2025 Minnesota Pulmonary Hypertension Consortium is set for November 21, 2025, 5:30 to 9:00pm at the Saint Paul Hotel. More details coming soon!

09/01/2025

Exciting news for the pulmonary hypertension (PAH) community! Our new publication, "Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension," is now live in JACC: Basic to Translational Science. This marks a significant step forward as it's the first human pilot trial to study microbiota transplant therapy (MTT) in PAH patients.

The study enrolled 11 patients and found that MTT is safe and feasible, with no serious or severe adverse events related to the treatment. We observed that the therapy was associated with a transient reduction in circulating proinflammatory cytokines and a modest level of donor bacterial engraftment. While the study did not show statistically significant changes, we did observe positive trends, including an increase in the six-minute walk distance and an improvement in quality of life scores.

These findings suggest that modulating the gut microbiome may be a promising new therapeutic strategy for PAH. We are hopeful that this research will pave the way for further investigation into new treatment options for patients.

08/26/2025

Congratulations to Dr. Michael Zhang on receiving his K08 grant for "Reverse translational multi-omics to identify treatment targets for atrial myopathy" (9/1/25 - 8/31/26)! This innovative project employs cutting-edge technologies and methodologies to advance understanding of atrial myopathy. Dr. Zhang's mentorship team includes primary mentor Dr. Lin Yee Chen and co-mentors Drs. Wei Pan, Timothy O'Connell, and Timothy McKinsey.

08/25/2025

Save the Date - Sept 19, 2025 | Noon *Zoom only*
ATRIA Lecture
"Foundational concepts in biomedical AI; Best practices in Health AI and roadmaps for successful Clinical and Research AI"

Constantin Aliferis, MD, PhD
ATRIA Co-Director
Director, Institute for Health Informatics (IHI)
Chief Research Informatics Officer, Clinical and Translational Science Institute (CTSI)

08/18/2025

Congratulations to Karim Azzag, PhD, winner of the Postdoc Poster Award at Cardio Palooza 16!
Dr. Azzag has been a member of the Perlingeiro lab since 2018. The title of his project is “Preclinical studies of an allogeneic off-the-shelf iPSC-derived myogenic progenitor cell product in a nonhuman primate model.”

07/22/2025

Please join us in welcoming Dr. Selma Carlson to the Division. We’re thrilled to have her on board and look forward to the expertise, energy, and dedication she will bring to our team.

Dr. Carlson completed internal medicine residency and cardiology fellowship at University of Washington in Seattle, and advanced multimodality cardiovascular imaging fellowship at Minneapolis Heart Institute. Her clinical interests include hypertrophic cardiomyopathy, aortic disease, preventive cardiology, and women’s cardiovascular health. Her research efforts are focused on the clinical application of cardiac CT and stress CMR for patients with coronary artery disease, use of cardiac CT in planning of complex structural interventions, and the role of multimodality imaging in women’s cardiovascular health. She also has an interest in cardiac imaging fellowship training/education.

07/21/2025

Please join us in congratulating faculty members on their recent promotions. We are grateful for their continued contributions to education, research, and clinical care.

Rebecca Cogswell, MD - Professor
Chetan Shenoy, MBBS, MS - Professor
Rajat Kalra, MBCHB, MS - Associate Professor
Forum Kamdar, MD, PhD - Associate Professor
Jeremy Markowitz, MD - Associate Professor

Address

2231 6th Street SE, 4-156 CCRB
Minneapolis, MN
55455

Opening Hours

Monday	8am - 4:30pm
Tuesday	8am - 4:30pm
Wednesday	8am - 4:30pm
Thursday	8am - 4:30pm
Friday	8am - 4:30pm
Saturday	8am - 4:30pm
Sunday	8am - 4:30pm

Website

http://www.lhi.umn.edu/

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