04/29/2026
Medication Spotlight
HMG-CoA Reductase Inhibitors How Statins Work Statins remain the primary pharmacological intervention for dyslipidemia. By inhibiting the HMG-CoA reductase enzyme, these medications reduce cholesterol production in the liver and increase LDL receptor expression. Clinical tip: While some statins require evening dosing, Atorvastatin and Rosuvastatin have long half-lives and can be administered at any time of day.