MedicalResearch.com, Narberth, PA (2025)

12/05/2024

MedicalResearch.com Interview with:

Miriam A. Bredella, MD, MBA
Bernard and Irene Schwartz Professor of Radiology & Vice Chair for Strategy
Associate Dean for Translational Science
Director, Clinical and Translational Science Institute
NYU Grossman School of Medicine
NYU Langone Health
Translational Research Building 743
New York, NY 10016

MedicalResearch.com: What is the background for this study?

Response: We perform >80 million CTs every year in the US, and there is a lot of information on these CTs that is not used and “thrown away.” Opportunistic imaging or opportunistic screening with the help of AI takes advantage of this information and automatically detects and quantifies vascular calcification, bone mineral density, abdominal fat or muscle mass. In our study, we wanted to detect whether calcification of the abdominal aorta, quantified using AI, could predict coronary artery calcification and major cardiovascular events (e.g.
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The information on routine CTs should be used in combination with standard clinical risk factors to determine cardiovascular risk and initiate therapy before patients suffer a heart attack or stroke.

12/05/2024

MedicalResearch.com Interview with:

Diana W. Bianchi, M.D.
Senior Investigator
Center for Precision Health Research
Director,
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health

MedicalResearch.com: What is the background for this study?

Response: The ability of prenatal cell-free DNA (cfDNA) sequencing to incidentally detect maternal cancers has been demonstrated by several retrospective studies from commercial or national laboratories. However, there are no standardized approaches to the identification and medical management of prenatal screening results that might indicate a maternal cancer. We sought to prospectively identify DNA sequencing patterns and other biomarkers that could distinguish which women with nonreportable or unusual cfDNA sequencing results had cancer and to determine the best approach for diagnostic work-up of pregnant people who receive these results.
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Lymphoma was the most frequently detected cancer, followed by colorectal cancer. However, several rare and unexpected cancers in young people, such as adrenocortical carcinoma, pancreatic cancer, and lung cancer were also detected.

11/30/2024

MedicalResearch.com Interview with:

Sean B. Fain, Ph.D.
Professor and
Vice Chair for Research
Department of Radiology
Affiliate Appointments BME and ECE
University of Iowa
Iowa City, IA

MedicalResearch.com: What is the background for this study?

Response: This study uses MRI to investigate connections between lung and brain function. We employ an advanced MRI technique that uses hyperpolarized xenon gas as a contrast agent. This approach allows us to image which parts of the lung are effectively inhaling xenon gas and which parts are not (i.e. ventilation).

Additionally, xenon provides insights into lung gas exchange (i.e. oxygen transfer into and out of the blood), as it freely diffuses into alveolar tissue and binds to red blood cells. Using this technology, we hypothesized that the severity of lung injury in individuals with Long COVID would correlate with the degree of cognitive dysfunction and brain imaging.

MedicalResearch.com: What are the main findings?
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The main findings of the study indicate that lung function, assessed using hyperpolarized xenon, is associated with cognitive function testing, brain volume, and brain perfusion.

11/07/2024

MedicalResearch.com Interview with:

Prof. Dina Schneidman-Duhovny PhD
Academic researcher
Hebrew University of Jerusalem

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The study analyzed genetic data of 12 families (~ 40 patients) with high incidence of breast cancer cases. Most families originate from ethnic groups that are poorly represented in public resources.

All participants were tested negative to all known breast cancer predisposing genes. We developed a novel approach to study genetic variants utilizing state-of-the-art deep learning models tailored for analysis of familial data.

The study highlighted 80 high-risk genes (out of > 1200 genes) and narrowed down on a group of 8 genes circulating in 7 out of 12 families in the study.

These genes are involved in a cellular organelle called the peroxisome and play a role in fatty acids metabolism.
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This study emphasizes the importance of expanding the breast cancer genetic catalog beyond high-penetrance genes.

10/31/2024

MedicalResearch.com Interview on publication of:

Prof. dr. H.J. (Hiddo) Lambers Heerspink
Clinical Pharmacologist
Faculty of Medical Sciences
University of Groningen

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The diabetes drug semaglutide, also known as Ozempic, has a positive effect for patients with chronic kidney damage and obesity. The amount of protein in their urine decreased, as did the degree of inflammation of their kidneys and their blood pressure.

Hiddo L. Heerspink got the idea for this study at the beginning of the corona pandemic. Earlier, he had discovered that another class of drugs against diabetes-2, the so-called SGLT2 inhibitors also appeared to work well for patients with chronic kidney damage without diabetes. He therefore wanted to investigate whether semaglutide would also work positively for patients with chronic kidney disease and obesity.
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'The great thing is that the drug has both direct and indirect effects on the kidneys. The drug has direct effects on inflammation parameters in the kidney, and lowers fat tissue around the kidneys, lowering the amount of protein in the urine. And indirectly because it reduces participants‘ weight...

10/31/2024

MedicalResearch.com Interview with:

Sarah Keim, PhD
Associate Professor, Epidemiology
College of Public Health
The Ohio State University

MedicalResearch.com: What is the background for this study?

Response: Ma*****na is the illicit substance most commonly used during pregnancy, and use is increasing. Some evidence suggests that ma*****na is associated with deficits in executive function and increased delinquent behavior in school-age children and adolescents, with potential downstream impacts on achievement and social functioning.

However, this evidence comes largely from only 2 studies several decades old. Today cannabis is more than 10 times more potent than it was several decades ago.

MedicalResearch.com: What are the main findings?
# # *****nainpregnancy # # # *****na

In this study, prenatal cannabis exposure was associated in early childhood with poorer thinking skills and behaviors such as impulse control, paying attention, planning ability, and more aggressive behavior.

10/27/2024

MedicalResearch.com Interview with:
Daniel J. Kruger, PhD
University of Michigan

MedicalResearch.com: What is the background for this study?

Response: A team of researchers from the University of Michigan and University at Buffalo teamed up with psychedelic advocates and therapists to document some of the challenges with psychedelics. They surveyed over a thousand psychedelic users about their adverse experiences and the experiences they have heard from others.

Most reported being frightened, sadness, loneliness, and feeling their body tremble or shake at times. Some people experienced panic, paranoia, felt that they are dead, or that the state they were in would last forever. One in ten participants had adverse physical reactions. For most people having these experiences, they are rare or happen sometimes, but they are still significant. Most of the people that experienced a severe adverse event did not have guidance from someone who was knowledgeable about psychedelics.
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Psychedelic experiences can be very intense and even people who have used them many times can have difficulties. It is essential to prevent, identify, manage, and treat adverse events during psychedelic experiences to ensure the safety and well-being of the participants and the facilitators.

10/15/2024

MedicalResearch.com Interview with:

Frank F. Zhou | he/him
MD Candidate, Class of 2025
David Geffen School of Medicine at UCLA

MedicalResearch.com: What is the background for this study? What is Lecanemab used for? How is it given to patients?

Response: Lecanemab is a new infusion therapy for Alzheimer's disease.
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Medicare is currently spending significant amounts of money on a costly medicine, only to throw it away. Simple policy changes could reduce this waste, including changing vial sizes, or developing new protocols to allow sharing vials between patients.

10/11/2024

MedicalResearch.com Interview with:

David-Dan Nguyen MDCM MPH
Doctoral Student
Institute of Health Policy Management and Evaluation and
Resident Physician
Division of Urology
University of Toronto
MedicalResearch.com: What is the background for this study?

Response: Peer reviewers are crucial to the academic publishing process.
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Our study highlights the need for transparency and stronger oversight of conflicts of interest among peer reviewers to maintain the integrity of the review process and public trust.

10/10/2024

MedicalResearch.com Interview with:

Stanley Hazen, MD, PhD
Chair, Cardiovascular & Metabolic Sciences
Lerner Research Institute
CoSection head, Preventive Cardiology & Cardiovascular Rehabilitation
Heart, Vascular and Thoracic Institute
Cleveland Clinic

MedicalResearch.com: What is the background for this study?
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We found that ABO blood type – a genotype that some early studies indicated could be linked to COVID risk, were involved in the post-COVID-19 heightened MACE risk.

10/01/2024

MedicalResearch.com Interview with:

Jiyoung Ahn, PhD
Professor of Population Health, NYU Grossman School of Medicine
Associate Director for Population Science, NYU Perlmutter Cancer Center
NYU Langone Health
Smilow Research Building
New York, NY 10016

MedicalResearch.com: What is the background for this study? What are the main findings?
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MedicalResearch.com Interview with: Jiyoung Ahn, PhD Professor of Population Health, NYU Grossman School of Medicine Associate Director for Population Science, NYU Perlmutter Cancer Center NYU Langone Health Smilow Research Building New York, NY 10016 MedicalResearch.com: What is the background for....

09/27/2024

MedicalResearch.com Interview with:

Dr De Alwis, Ruklanthi (Rukie)
Deputy Director, Centre for Outbreak Preparedness
Assistant Professor
Emerging Infectious Diseases Programme
Duke-NUS Medical School

MedicalResearch.com: What is the background for this study?

Response: The COVID19 pandemic highlighted both the need for strengthened infectious disease surveillance and the critical importance of pathogen genomics in surveillance.
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There is a diversity of pathogen genomic surveillance capacity across the Asian region, with more work needed to level the playing field across low-, middle-, and high-resource settings.

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