Hyde Drug Store

Hyde Drug Store Your local, family owned & operated pharmacy with Pharmacy Compounding available to all PA residents. We offer products and services beyond your pharmacy needs.

We have a full line of home healthcare items and equipment regularly available, including wheelchairs and walkers, respiratory supplies, support stockings and more. Our Compounding department specially formulates medicine for your individual needs, including your pet! Check out our website for additional services offered, including vaccine administration. Fun Fact: Hyde Drug Store is the oldest, continuously operating pharmacy in Lawrence County!

You know that saying...“it’s the little things”? 💬Our health tends to work the same way. Small details like timing are e...
02/05/2026

You know that saying...“it’s the little things”? 💬
Our health tends to work the same way.

Small details like timing are easy to overlook, yet can impact how a prescription works.

The little things can make a difference, in more ways than one.

It's Groundhog Day! 🦫More winter...or an early spring?Either way, we’re here to help you get through the seasonal stuff....
02/02/2026

It's Groundhog Day! 🦫
More winter...or an early spring?

Either way, we’re here to help you get through the seasonal stuff.

Hoping everyone is staying warm. ❄️

❄️ Weather Conditions ❄️Now’s a good time to check in on your medications. 💊If you’re due for refills or need any over t...
01/23/2026

❄️ Weather Conditions ❄️

Now’s a good time to check in on your medications. 💊

If you’re due for refills or need any over the counter items, we’ll be here during our regular Saturday hours tomorrow, 1/24 from 9am-4pm.

We’ll be sure to keep you informed if anything changes with our in-store and delivery availability for next Monday, 1/26.

Stay safe, stay warm, and we’ll see you soon. ❄️



Well isn't this quite the oldie!  🕰️Our old store on Liberty St.  Before the makeover... good old-school Hyde Drug and t...
01/23/2026

Well isn't this quite the oldie! 🕰️
Our old store on Liberty St. Before the makeover... good old-school Hyde Drug and the start of our story.


#1978

💬 Please read…Just a quick heads-up.  If you’re able, please take a moment to read and share.We want to let everyone kno...
01/15/2026

💬 Please read…

Just a quick heads-up. If you’re able, please take a moment to read and share.

We want to let everyone know that a recent email circulating *did not* come from Spero Stefanis or Hyde Drug Store.

If you happened to receive this message mentioning a file upload or asking you to click a link, please ignore it and delete it.

Our systems are secure, there is no ongoing risk, and additional safeguards are in place.

No further action is needed on your part once it's deleted.

As always, we’re here if you have questions.

Thank you for helping us spread the word, and thank you for your continued trust.

January =  fresh starts and...insurance resets. 🗓️ If questions come up at pickup, we’re happy to help where we can or p...
01/10/2026

January = fresh starts and...insurance resets. 🗓️
If questions come up at pickup, we’re happy to help where we can or point you in the right direction. 🙂



Address

2412 Wilmington Road
New Castle, PA
16105

Opening Hours

Monday 8am - 7pm
Tuesday 8am - 7pm
Wednesday 8am - 7pm
Thursday 8am - 7pm
Friday 8am - 7pm
Saturday 9am - 4pm

Telephone

+17246521451

Alerts

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Hyde Drug Store | For all of your healthcare needs

Hyde Drug Store was founded by Alfred Hyde in 1890. Mr. Hyde operated the pharmacy and transitioned ownership to his son, Alfred, who operated the pharmacy until the mid 1950’s.

The Hydes began a tradition of personal service for their patients that has been continued through 2 more sets of owners until the pharmacy was purchased by Pharmacist George Stefanis, graduate of the University of Pittsburgh School of Pharmacy, in 1978. George has maintained the level of personal service created by the Hydes, and by utilizing the modern technology available to pharmacies today, Hyde Drug Store has taken personal service to a new level. This type of pharmacy practice is not something you find at the large corporate pharmacies that everyone is familiar with.

George’s son, Spero Stefanis Pharm. D. joined the practice officially in 2012, although he spent the previous 8 years working at the pharmacy while attending high school and college. Spero has brought with him all the knowledge of a recent graduate of Duquesne University School of Pharmacy and the technological skills available to best deliver up to date patient care.

The Hyde Drug Store team is easily accessible. We are open 7 days a week and when you call us, a person answers the phone. George and Spero plan to continue practicing pharmacy at Hyde Drug Store, attending to their patients’ needs for many years to come. Hyde Drug Store is the oldest, continuously operating pharmacy in the state of Pennsylvania and we plan to see that Hyde Drug Store continues these traditions.