Hyde Drug Store

Hyde Drug Store Your local, family owned & operated pharmacy with Pharmacy Compounding available to all PA residents. We offer products and services beyond your pharmacy needs.

We have a full line of home healthcare items and equipment regularly available, including wheelchairs and walkers, respiratory supplies, support stockings and more. Our Compounding department specially formulates medicine for your individual needs, including your pet! Check out our website for additional services offered, including vaccine administration. Fun Fact: Hyde Drug Store is the oldest, continuously operating pharmacy in Lawrence County!

Our holiday hours 🎄Please note, we’ll have shortened hours on Christmas Eve and New Year’s Eve as shown in the graphic a...
12/18/2025

Our holiday hours 🎄

Please note, we’ll have shortened hours on Christmas Eve and New Year’s Eve as shown in the graphic and listed below:

🌟 Christmas Eve: Open 8am–1pm
🎁 Christmas Day: Closed
🎉 New Year’s Eve: Open 8am–5pm
🎇 New Year’s Day: Closed

Save this post and share with family and friends so everyone is in the know! 😊





12/06/2025

👀 A little sneak peek into the Christmas magic happening inside the store. ✨

The cards, the decor, the holiday vibes...come see all the goodness waiting for you inside!

We are always so glad to see you! ☺️









Address

2412 Wilmington Road
New Castle, PA
16105

Opening Hours

Monday 8am - 7pm
Tuesday 8am - 7pm
Wednesday 8am - 7pm
Thursday 8am - 7pm
Friday 8am - 7pm
Saturday 9am - 4pm

Telephone

+17246521451

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Hyde Drug Store | For all of your healthcare needs

Hyde Drug Store was founded by Alfred Hyde in 1890. Mr. Hyde operated the pharmacy and transitioned ownership to his son, Alfred, who operated the pharmacy until the mid 1950’s.

The Hydes began a tradition of personal service for their patients that has been continued through 2 more sets of owners until the pharmacy was purchased by Pharmacist George Stefanis, graduate of the University of Pittsburgh School of Pharmacy, in 1978. George has maintained the level of personal service created by the Hydes, and by utilizing the modern technology available to pharmacies today, Hyde Drug Store has taken personal service to a new level. This type of pharmacy practice is not something you find at the large corporate pharmacies that everyone is familiar with.

George’s son, Spero Stefanis Pharm. D. joined the practice officially in 2012, although he spent the previous 8 years working at the pharmacy while attending high school and college. Spero has brought with him all the knowledge of a recent graduate of Duquesne University School of Pharmacy and the technological skills available to best deliver up to date patient care.

The Hyde Drug Store team is easily accessible. We are open 7 days a week and when you call us, a person answers the phone. George and Spero plan to continue practicing pharmacy at Hyde Drug Store, attending to their patients’ needs for many years to come. Hyde Drug Store is the oldest, continuously operating pharmacy in the state of Pennsylvania and we plan to see that Hyde Drug Store continues these traditions.