05/20/2022
Poor quality embryos due to fragmentation? Research shows that embryo fragmentation is associated with a range of factors, including inadequate culture conditions, poor quality of the o**m and spermatozoon, increased maternal age, chromosomal abnormalities, abnormal cell cycle, apoptosis, and oxidative stress in embryos.
The presence of fragmentation limits the subsequent development of embryos due to the loss of cytoplasmic mitochondria, mRNA, and regulatory proteins, which are essential for cell division, as well as physical interruption of the gap junctions in blastomeres, which interferes with the cell-cell interactions required for cleavage and compaction.
Cellular fragmentation can induce programmed cell death or apoptosis in blastomeres. These fragments have been shown to secrete harmful substances that adversely affect the surrounding healthy cells, resulting in impaired embryo development, decreased implantation potential and pregnancy rate, and an increased abortion rate.
Furthermore, excessive fragments may induce arrest of embryo development, apoptosis and necrosis of blastomeres, and abnormal embryo development, compaction, and blastocyst formation.