LifeNome

11/29/2023

Addicted to ? There may be to explain it !

The first study of its kind "The first genome-wide association study of internet addiction; Revealed substantial shared risk factors with neurodevelopmental psychiatric disorders "

reports 72 single nucleotide polymorphisms SNPs associated with internet addiction disorder (IAD)

IAD is listed as a disorder requiring further studies in the diagnostic and statistical manual of mental disorders (DSM-V). Psychological studies showed significant co-morbidity of IAD with , abuse, and .

Study of over 34000 people (16,520 with IADs and 18,000 matched non-psychiatric subjects) identified seventy-two in 24 genes significantly associated with IAD. Most of these SNPs were risk factors for . Most similarity detected with spectrum disorder, and .

Higher anxiety, stress, and and deficits in working memory, attention, planning, and processing speed were detected in IADs.

risk factors in IADs may cause several and neurodevelopmental abnormalities, which lead to excessive Internet usage. It may suggest that IAD could be a marker for vulnerability to developmental psychiatric disorders.

11/24/2023

Everyone heard about the mapping of every strand of DNA that makes up a person. But there are other

Genomics can allow doctors to predict what kinds of diseases a patient will get long before they present symptoms, staving off

Transcriptomics studies that are transcribed from and studies linking the and proteome together.

Proteomics, the study of proteins, where most diseases are manifested. has a 90% failure rate, due in part by the fact that most drugs are built to latch onto targets in the body that aren’t successful. Protein study is the key to unlocking new targets in the body for drugs to swim to.

Metabolomics can be used to tailor medicines to properly work in the human body, and companies can see how drugs metabolize in the body and change them so they work faster, better and safer.

We've only recently begun to tap into this set of sciences to create tailor-made medicines and treatments for each person instead of one-size-fits-all drugs

The is a booming industry in biotech, garnering more than $2.4 billion in venture funding as we entered December 2022, according to Crunchbase.

Even Amazon Web Services (AWS) got involved in November with introduction of Amazon Omics.

The "omics" — genomics, transcriptomics, metabolomics and proteomics — are booming in biotech, with more big raises expected in 2023.

11/20/2023

How and methods help elucidating underlying , modifiable behavior to improve , preventive interventions, and counseling for patients.

(AD) is a global skin disease affecting up to 20% of children and 10% of adults, imposing a significant burden.

and factors, including family history, contribute to its etiology.

The condition is linked to comorbidities like , and issues.

Many prior studies investigating AD risk factors have been observational in nature and faced limitations. Evidence on definitive risk factors remains inconclusive.

One statistical methodology called Mendelian randomization (MR) investigates causal factors for AD development using variants identified in -wide association studies
MR, relying on fixed genetic variants, minimizes bias and confounding. MR offers advantages over randomized in some cases, but it requires strict assumptions for validity, including the absence of confounders and independent pathways.

New systematic review "Mendelian randomization studies in atopic dermatitis: a systematic review" https://lnkd.in/eeUe25f8 summarizes 30 MR studies exploring the causal relationship between various exposures and AD development, addressing potential reverse causation relationships.

Body mass index , and gastroesophageal reflux disease were among causal factors for AD, while AD was causal for several medical conditions including and .

Serum of IL-18, IL-18R1, and IL-6R1 also increased the susceptibility for AD development.

These insights may improve preventive counseling in AD.



Figure demonstrates the overall effect of variables found to have a significant causal effect on AD or vice-versa varied .

11/17/2023

Fascinating intersection of foodborne functional components, like , , and materials, reveals their significant impact on including

Despite their recognized importance, the precise mechanisms through which these components enhance remain a puzzle.

The skin serves as the outermost barrier, playing a pivotal role in upholding internal equilibrium and safeguarding against external microbial threats. Similarly, the gut microbiota functions as a barrier, connecting the external environment of the intestines to the internal environment, which includes the skin. The intricate interplay among the cutaneous barriers, encompassing physical, chemical, , and elements, collaborates to maintain a protective balance within the skin ecosystem.

Moreover, the local neuro-endocrine- in the skin plays a crucial role in regulation and protection.

Comprehensive review "Oral and external intervention on the crosstalk between microbial barrier and skin via foodborne functional component" https://lnkd.in/gHQ2BVY4 sheds light on the indispensable roles of -targeted foodborne functional components in influencing and optimizing .

By examining the dynamic relationship between food and skin barriers, new research would deepen our understanding of how interventions at the level contribute to skin ecosystem .

Follow Beauty Tech & Biotech https://lnkd.in/ePYBuT7

11/14/2023

Autoimmune diseases (ADs) pose a widespread challenge, where the body's targets its own healthy cells. This prevalent condition impacts global health, with prevalence ranging from 5 to 500 cases per 100,000 individuals.

According to the National Stem Cell Foundation , approximately 4% of the world's population is affected, imposing a significant societal burden due to the associated high treatment costs.

ADs exhibit a distinct disproportionately affecting women at a rate of 2:1 compared to men.

The complex etiology involves a combination of and factors, with a higher likelihood of development in genetically susceptible individuals.

ADs treatment involves a spectrum of biological and synthetic drugs targeting various immune system components, including Janus kinase inhibitors, non-receptor tyrosine-protein kinase, and cytokines.

However, these immune-modulatory drugs, while effective, often come with non-specific actions and a range of side effects, such as infections and malignant diseases.

emerges as a promising avenue for ADs treatment, aiming to regulate cytokine levels and lymphocyte infiltration through the delivery and expression of therapeutic genes.

Recent genomic-wide association studies have identified genetic loci associated with susceptibility to common ADs, offering insights into potential targeted .

New review "Role of genetics in eleven of the most common autoimmune diseases in the post genome-wide association studies era" https://lnkd.in/dKckh-re
provides a comprehensive overview of genetic factors linked to susceptibility in 11 prevalent ADs, including Grave’s disease, Sjögren’s syndrome (SS), thyroiditis (HT), Anti-phospholipid syndrome (APS), hemolytic anemia, Systemic lupus erythematosus and systemic sclerosis.

On the figure : there are factors affecting the initiation of . Genetic polymorphisms in gene-related to , including HLA, cytokines, autoimmune regulators or receptors can lower the threshold for the activation of autoreactive that activate autoreactive leading to the production of autoreactive .

Environmental factors including and [central , reactive oxygen species (ROS), and PTSD] can generate a proinflammatory environment that supports the initiation of autoreactive T and B-cells.

11/13/2023

Would you like to have a glimpse of your future health?

enabled by and other data would soon make it possible.

It’s easy to envision a day when every person has a digital health twin that mirrors our physical and makeup and , a doppelgänger we can feed hypothetical inputs to and see what effects they may have on our bodies.

For example, a digital health twin could show us how adhering to a diet would impact our specific body over the next 20 years.

Or our twin might be able to reveal the effect that physical stresses on our body will have as we continue to —what another 10 years of sitting at our desk at work will do to our spine, for example.

A digital twin may even be able to show us which option for a disease is better for us by revealing how our unique body would react if we chose to undertake one treatment plan instead of another, say medication versus surgery.

All this sounds far-fetched, but the digital twinning of organs and entire bodies is already well underway in the healthcare industry. It’s just a matter of time before the technology can be applied to each unique individual as well.



by Fast Company

What is a digital twin? Why is everyone building one? Here's what you should know about the technology that's reshaping logistics, cities, healthcare, and more

11/06/2023

Our genes play an important role in how we process nutrients. 🥦

Some people may metabolize certain vitamins and minerals more efficiently, while others might struggle due to genetic variations. 🧬

This genetic variability can influence how our bodies absorb, transport, and utilize essential nutrients.
If our nutrient processing is impaired due to our genetic makeup, there's a risk that we won't be able to get enough of the nutrients we consume by just adhering to the average FDA Daily Values (DV).

By using our report with your clients, you can have a more precise assessment of their unique nutritional needs, paving the way for the implementation of a highly tailored intervention. 📝

10/26/2023

New findings about what affects and how it in turn affects

The quest for improved sleep quality and optimal duration is ongoing, with the global sleep aid and technology market exceeding $80 billion annually.

Sleep, affected by and various demographic, social, and environmental factors like socioeconomic status, stress, living conditions, work or school schedules, medications, and health, is crucial for overall well-being and can serve as both a health risk and a symptom of various conditions.

A comprehensive Genome-Wide Association Study on self-reported sleep duration not only confirms known associations with sleep traits but also reveals new genetic loci related to shorter and longer sleep durations. These findings involve genes of interest in diverse populations, including European (EUR) and African (AFR) ancestry, and indicate shared genetic risks with and traits, advancing our understanding of sleep duration's genetic basis.

Both shorter and longer sleep durations are associated with higher all-cause and reduced .

Short sleep duration increases the risk of major disorder, and there's bidirectional causality between long sleep duration and MDD. Similar associations with exist, with a negative causal link with short sleep and a positive causal link with long sleep duration, as well as bidirectional causality in the case of long sleep.

The data underscores the significant influence of solar irradiation, and collecting longitudinal data over several years will be valuable for fully understanding the impact of daylight hours on sleep duration.

These findings highlight the value of understanding the basis of sleep patterns in order to improve .

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