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Brain scans aren’t just for injuries.⁠⁠They may also reveal how fast you’re aging, according to a recent study published...
08/20/2025

Brain scans aren’t just for injuries.⁠

They may also reveal how fast you’re aging, according to a recent study published in Nature Aging.⁠

Scientists analyzed over 50,000 MRI scans and used AI to spot patterns that reflect biological brain aging—not just chronological age. ⁠

Features such as the thickness of the cerebral cortex, an area that controls language and thinking, and the volume of gray matter can predict the rate at which a person’s ability to think and remember will decline, as well as risk of frailty, disease, and death. ⁠

“Imaging offers unique, direct insights into the brain’s structural aging, providing information that blood-based or molecular biomarkers alone can’t capture,” Mahdi Moqri, a computational biologist at Harvard Medical School, told Nature. ⁠

The research is still in its early stages—it’s not ready for clinical use yet. But this breakthrough could help identify who is at risk for age-related cognitive decline and dementia years before symptoms appear. ⁠

Study: Ledford H. How fast are you ageing? Ordinary brain scans reveal the pace. Nature. 2025 Jul;643(8071):314-315. doi: 10.1038/d41586-025-02086-9. PMID: 40594931.

Can magic mushrooms slow aging? A new npj Aging study reports that psilocybin, best known for its psychedelic properties...
08/19/2025

Can magic mushrooms slow aging?

A new npj Aging study reports that psilocybin, best known for its psychedelic properties and promise in treating mental health conditions, may also slow aspects of biological aging.

In human cell culture models, its active metabolite psilocin conferred a variety of benefits:
🍄 Extended cellular lifespan by up to 57%
🍄 Preserved telomere length
🍄 Reduced markers of senescence and oxidative stress
🍄 Boosted SIRT1—a protein associated with longevity

In aged mice, monthly psilocybin treatment improved survival (80% vs. 50% in controls) and appeared to enhance fur quality late in life. The findings suggest psilocybin could act on multiple hallmarks of aging, raising the possibility of its use as a longevity intervention.

Here’s what the study authors had to say: “Psilocybin may represent a ‘disruptive’ pharmacotherapy as a novel geroprotective agent to promote healthy aging and/or as a potential therapeutic intervention for age-related diseases.”

Your brain may be getting older, but it’s not done growing!⁠⁠A landmark study just confirmed what scientists have been d...
08/01/2025

Your brain may be getting older, but it’s not done growing!⁠

A landmark study just confirmed what scientists have been debating for decades: Adults do make new neurons.⁠

In a study published in Science, researchers at Sweden’s Karolinska Institute studied postmortem brain tissue from young children and used advanced tools to look at the activity inside over 100,000 individual brain cells. By analyzing the cells’ RNA—the genetic instructions cells use to function—they were able to spot patterns that showed whether a cell was young, developing, or fully mature. They then looked for those same markers in brain tissue from teens and adults up to age 78.⁠

All but one adult brain still had immature neurons, and more than 63% had neural precursor cells, which can develop into new neurons.⁠

"Although the precise therapeutic strategies in humans are still under active research, the very fact that our adult brains can sprout new neurons transforms how we think about lifelong learning, recovery from injury, and the untapped potential of neural plasticity,” said co-lead study author Marta Paterlini, a researcher at the Karolinska Institute in Stockholm.

Many women don’t think about bone health until menopause or later, but women can reach peak bone mass by age 18! A recen...
08/01/2025

Many women don’t think about bone health until menopause or later, but women can reach peak bone mass by age 18!

A recent Women’s Health article highlights how more women in their 20s, 30s, and 40s are taking charge of their bone health, getting early bone density scans, lifting heavy weights, and paying close attention to nutrition and hormones to build a stronger bone foundation before age-related loss begins.

“We’ve really come around to recognize that younger adulthood is an important time in health,” says Taylor Wallace, Ph.D., an adjunct clinical associate professor at George Washington University School of Medicine and Health Sciences. “You can think of your bones like a Roth IRA, or a retirement account.” The more you can build up in bone health when you’re young, the bigger the return later on.

With nearly half of women over 50 expected to break a bone due to osteoporosis, experts say early awareness and action can make all the difference.

Small daily habits = big yearly wins for your longevity. ⁠⁠It’s easy to underestimate the power of small actions, but wh...
07/13/2025

Small daily habits = big yearly wins for your longevity. ⁠

It’s easy to underestimate the power of small actions, but when practiced consistently, they lay the foundation for healthy aging. These aren’t just wellness buzzwords—they’re science-backed habits that compound over time to support your body and brain. ⁠

Here are the habits and why they’re worth focusing on every day: ⁠

🚶Walking: Boosts brain health, lowers the risk of chronic disease, supports mood and mobility. ⁠
🏋️Strength training: Preserves muscle mass, bone density, and metabolic resilience as you age. ⁠
💧Water: Supports cellular health, kidney function, and metabolic waste removal. ⁠
💤Sleep: Critical for immune function, brain detox, and metabolic repair. ⁠
👪Connection: Strong social ties are linked to reduced mortality risk and longer healthspan. ⁠

Are you building a recipe for longevity?

Let’s talk about a popular myth: "Sunscreen causes cancer.”⁠⁠The truth? There’s no credible evidence to suggest that sun...
07/10/2025

Let’s talk about a popular myth: "Sunscreen causes cancer.”⁠

The truth? There’s no credible evidence to suggest that sunscreen increases your risk of cancer. In fact, studies show that regular use of sunscreen prevents skin cancer by protecting against UV radiation, a known carcinogen. ⁠

Where does the suspicion come from? ⁠

A 2020 randomized clinical trial found that six FDA-approved UV filters in sunscreen (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) can be absorbed into the bloodstream. In lab and animal studies, some of these filters have been linked to potential hormone disruption, which raised public concern. Absorption, however, doesn’t equal harm, and there’s currently no conclusive evidence showing these ingredients cause health issues or cancer in humans.⁠

In 2021, a third-party lab detected benzene—a known human carcinogen—in some sunscreens. It’s important to note that this was due to contamination during the manufacturing process; benzene is not an intentional sunscreen ingredient. The contaminated products were recalled and the FDA continues to monitor for safety. ⁠

The FDA has called for more research on sunscreen ingredients, but continues to recommend sunscreen to prevent skin cancer. ⁠

Mineral UV filters zinc oxide and titanium dioxide are considered safe, effective, and are not absorbed systemically. But whether you choose a mineral or a chemical sunscreen, the consensus is clear: ⁠

The risk comes from unprotected sun exposure, not from sunscreen. ⁠

Studies: Gordon L, Olsen C, Whiteman DC, Elliott TM, Janda M, Green A. Prevention versus early detection for long-term control of melanoma and keratinocyte carcinomas: a cost-effectiveness modelling study. BMJ Open. 2020 Feb 26;10(2):e034388. doi: 10.1136/bmjopen-2019-034388. PMID: 32107270; PMCID: PMC7202703.⁠

Matta MK, Florian J, Zusterzeel R, et al. Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial. JAMA. 2020;323(3):256–267. doi:10.1001/jama.2019.20747

A landmark study in PNAS of 19,000+ people suggests brain aging doesn’t follow a slow, steady decline—it follows an S-cu...
07/01/2025

A landmark study in PNAS of 19,000+ people suggests brain aging doesn’t follow a slow, steady decline—it follows an S-curve.⁠

Degeneration begins around 44, peaks at 67, and plateaus by 90. The culprit? Neuronal insulin resistance, which limits the brain’s ability to use glucose for energy.⁠

But there’s good news: Researchers found that ketones—an alternative fuel that bypasses insulin—can help stabilize brain function, especially during the midlife “metabolic stress” window (ages 40–59), when neurons are vulnerable but not yet irreversibly damaged.⁠

“This represents a paradigm shift in how we think about brain aging prevention,” said lead author Botond Antal, Ph.D.

70 is the new 50! No, it’s not a headline after a red carpet event. It’s a science-backed finding! ⁠⁠The International M...
05/08/2025

70 is the new 50! No, it’s not a headline after a red carpet event. It’s a science-backed finding! ⁠

The International Monetary Fund (IMF) analyzed surveys from one million people aged 50 and older, living in 41 countries, that looked at memory, orientation, and basic math skills. The researchers found that someone aged 70 in 2022 had the same cognitive function as the average 53-year-old in 2000.⁠

The IMF also found that grip strength and lung function has also improved in older people. A 70-year-old person in 2022 had the same fitness level as the average 56-year-old 25 years ago.⁠

These findings suggest that older people can also work past the typical retirement age, adding to what the IMF calls “the rise of the silver economy.”⁠

Source: https://www.thetimes.com/business-money/economics/article/boomers-urged-keep-working-70-new-50-s669hbkw7

May is Women’s Health Month, and researchers have been delving into women’s strengths—literally.⁠⁠In a recent large-scal...
05/07/2025

May is Women’s Health Month, and researchers have been delving into women’s strengths—literally.⁠

In a recent large-scale study, Cedars-Sinai and other global researchers looked at data from 400,000 people to compare the effects of exercise in women and men. They found that women who strength train two to three times a week are more likely to live longer and have a 30% reduced risk of death from heart disease compared to women who don’t do strength training at all.⁠

The study also revealed that women derived greater gains than men from equivalent physical activity. Women who did moderate intensity exercise such as brisk walking five times a week (300 mins /week) lowered their risk of premature death by 24% compared to 15% for men. ⁠

Add these stats to your list of reasons to hit the gym today! ⁠

Study: https://www.jacc.org/doi/10.1016/j.jacc.2023.12.019

Meet the action figure that’s repping peak performance with the Elysium edge. 🧬Power up your longevity game with Dr. Leo...
04/11/2025

Meet the action figure that’s repping peak performance with the Elysium edge. 🧬

Power up your longevity game with Dr. Leonard Guarente and the exclusive lab accessory pack. 🔬

Blocking the internet on a cell phone for just two weeks improved focus in 58.5% of participants—equivalent to reversing...
04/09/2025

Blocking the internet on a cell phone for just two weeks improved focus in 58.5% of participants—equivalent to reversing 10 years of age-related decline in sustained attention, according to a recent study.⁠

Participants who had internet access blocked on their smartphones for two weeks saw improvements in attention span, mental health, and subjective well-being.⁠

The four-week study included 467 participants who were randomly placed into two groups. ⁠

Group one had no internet access on their smartphone for the first two weeks, while group two had no access to the internet for the second two weeks. Participants could use their phones to call and text, and they could access the internet while on a desktop computer or other device.⁠

Across both groups, 70.5% reported better mental health, 73.3% had improvements in subjective well-being, and 58.5% experienced an improvement in objectively measured sustained attention ability. ⁠

The researchers theorized that limiting internet use gave people more time for offline activities: socializing in person, exercising, spending time in nature, and pursuing hobbies—and they were right. The intervention positively affected how people spent their time, as well as improved their social connectedness, self-control, and sleep.⁠


Even better news, you don’t have to go cold turkey to get the benefits. Those who didn’t fully comply still had improvements, just not as strong as those who participated in the total two-week ban. ⁠


Would you take a break from your cell phone?⁠

Referenced study: Castelo N, Kushlev K, Ward AF, Esterman M, Reiner PB. Blocking mobile internet on smartphones improves sustained attention, mental health, and subjective well-being. PNAS Nexus. 2025 Feb 18;4(2):pgaf017. doi: 10.1093/pnasnexus/pgaf017. PMID: 39967678; PMCID: PMC11834938.

“He is an architect of one of the field’s biggest ideas,” writes Amy Dockser Marcus.
That’s just a small part of the rec...
04/02/2025

“He is an architect of one of the field’s biggest ideas,” writes Amy Dockser Marcus.

That’s just a small part of the recent profile of Elysium chief scientist Leonard Guarente, Ph.D. in The Wall Street Journal.

Dockser Marcus refers to Dr. Guarente as “a grandfather of the booming longevity movement,” saying he has trained its most influential scientists and helped create the company behind a suite of popular supplements.

The article chronicles Dr. Guarente’s early life, his research on sirtuins and NAD+ at MIT, and the ongoing development of Elysium Health, taking his clinically proven breakthroughs out of the lab and into the hands of the growing longevity community.

Comment “WSJ” and we’ll send you the link to the article.

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