Thomas Youm MD - Orthopaedic Surgeon

04/27/2026

Chondrogenesis of Peripheral Blood-Derived Mesenchymal Stromal Cells.

Articular cartilage, a highly specialised and avascular tissue, exhibits limited regenerative potential following trauma or degenerative conditions such as osteoarthritis (OA). Conventional surgical interventions, including microfracture and autologous chondrocyte implantation (ACI), have shown limi...

03/23/2026

Stem Cell Therapy for Spinal Cord Injury: Lessons from Japan`s Experiment in Regulatory Deregulation.

Stem cell-based therapies for spinal cord injury (SCI) have generated substantial global interest; however, no regenerative treatment has yet demonstrated sufficient efficacy to achieve full regulatory approval in major jurisdictions. In Japan, an expedited regulatory framework enabled the condition...

03/16/2026

Stem Cell Therapy for Traumatic Brain Injury: Current Advances, Clinical Challenges, and Future Directions.

The severity of traumatic brain injury (TBI) and its poor prognosis underscore the urgent need for more effective neuroprotective and neuroregenerative strategies. However, the pathological heterogeneity of TBI continues to hinder clinical therapeutic progress. Preclinical studies have shown that ne...

02/16/2026

From Scalpels to Stem Cells: How Regenerative Medicine Is Changing Spine Surgery.

For much of modern history, orthopedic surgery has relied on precision, hardware, and long recoveries. The rhythm was familiar: a problem in the spine or joint would lead to imaging, diagnosis, and ultimately surgery. But in the last decade, a quiet revolution has begun. Instead of opening the body....

02/09/2026

Stem Cell Pain Sponge Soaks up Osteoarthritis Joint Pain and Protects Cartilage.

SereNeuro Therapeutics revealed promising results for SN101, a first-in-class iPSC-derived therapy designed to treat chronic osteoarthritis pain while protecting joint tissue. Instead of blocking pain pathways, SN101 uses lab-grown nociceptors that act like sponges, soaking up inflammatory pain fact...

02/02/2026

Initial Safety Outcomes of Adipose-Derived Mesenchymal Stem Cell for Rotator Cuff Tear: A 3-Year Pilot Trial.

Injection of autologous MSCs derived from adipose tissue is safe in treating total rotator cuff tear. These findings support the initiation of larger-scale trials to further investigate the therapeutic potential and efficacy of MSCs in tendon regeneration.

01/23/2026

Regenerative Stem Cell Therapy: Good Alternative To Joint Replacement Surgery?

Stem cell therapy offers a minimally invasive alternative to joint replacement surgery, with recovery times of just one to two weeks compared to months for major surgery. Clinical studies show varying success rates, with 60-80% of patients in some trials experiencing significant pain relief and impr...

01/16/2026

Functionalized Mesenchymal Stem Cells for Enhanced Bone Regeneration: Advances and Challenges.

The functionalization of mesenchymal stem cells presents an exciting frontier in the field of bone regeneration therapies, with the potential to revolutionize current treatment strategies for bone defects and fractures. Significant advancements have been made through various techniques such as gene....

01/09/2026

Intra-Articular Delivery of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells (BM-MSCs) for Painful Lumbar Facet Arthropathy: A Phase I Clinical Trial.

This open-label, single-arm Phase I clinical trial demonstrated a favorable safety profile for intra-articular administration of allogeneic, culture-expanded BM-MSCs in the treatment of painful lumbar facet arthropathy. The manufacturing and delivery of the regimen were successful for all enrolled p...

12/18/2025

Efficacy and Safety of Single Versus Repeated Injections of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Both single and repeated MSC injections could improve pain and knee joint function in patients with KOA. Compared to single injections, repeated MSC injections may offer superior therapeutic benefits; however, they are associated with a higher incidence of adverse events. In clinical practice, poten...

11/27/2025

Wishing you and your family a wonderful Thanksgiving!

11/21/2025

Mesenchymal Stem Cells Injections in Traumatology and Orthopaedics: Common Practice or Still a Promising Area with Many Uncertainties?

MSC injections represent a growing area of research in traumatology and orthopaedics. However, the results of only a small proportion of clinical trials and systematic reviews are published in peer-reviewed journals, which most likely does not allow practitioners to form a full judgement on the effi...