03/05/2026
GLP-1 medications are not designed to be short-term treatments.
A new systematic review published in The BMJ looked at what happens when people stop taking weight-loss medications, including GLP-1s and the findings reinforce what many experts have been saying from the start.
When the medications are stopped, most people regain weight, often at a rate of about one pound per month, and many return to their pre-medication weight within 1.5–2 years. Improvements in blood sugar, cholesterol, and blood pressure also tend to move back toward baseline.
Importantly, people who lost weight on medication regained weight faster than those who lost weight through behavioral interventions.
This is not a moral issue.
It’s not a discipline issue.
It’s physiology.
The study didn’t examine mental health outcomes, but we know from long-term bariatric surgery research that weight regain can be associated with distress and shame, even when it’s biologically expected.
If you’re considering a GLP-1 for weight loss, informed consent matters. These medications are generally intended for long-term, often lifelong, use.
We’re living in a moment where GLP-1s are marketed as miracle cures. The real story is more nuanced.
You deserve the full picture.