07/16/2025
Acupuncture modulates the microbiota-gut-brain axis: a new strategy for Parkinsonâs disease treatment
Parkinsonâs disease is a relatively common neurodegenerative disorder in clinical practice, and its prevalence is increasing worldwide. It not only causes patients to have movement disorders such as tremors
and delayed initiation but also makes patients suffer from olfactory disorders, gastrointestinal disorders, insomnia and other symptoms, which brings a heavy burden to patients and their families. In recent years, some scholars believe that the brain-gut axis may be the key to revealing the pathogenesis of Parkinsonâs disease.
Changes in the intestinal flora, or bacterial infections and oxidative stress, lead to abnormal aggregation of alpha-synuclein(a-syn) and formation of neurotoxic Lewy bodies (LBs), which are transmitted to the central nervous system via the vagus nerve, causing Parkinsonâs disease (PD). A large number of evidence-based studies have shown that acupuncture is effective in treating motor disorders and non-motor symptoms such as constipation, neuropsychiatric symptoms, and dysphagia symptoms in Parkinsonâs disease, and this treatment is safe. However, its mechanism remains unclear. Acupuncture may affect the brain-gut axis and treat PD by improving intestinal flora imbalance, interfering with the expression of a-syn, protecting neurological function, anti-inflammation, and influencing glial cells, etc. Therefore, the aim of this review is to elucidate the pathogenesis of PD from the perspective of neural, immune, and metabolic signaling pathways of the microbiota-gut-brain axis. In addition, this paper integrates the mechanism of acupuncture treatment with the pathogenesis of PD for the first time and aims to provide potential new strategies for its treatment.
Link: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1640389/abstract