Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the field of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis (Universität zu Köln) show that RIPK1 ...
09/25/2025

Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis (Universität zu Köln) show that RIPK1 autophosphorylation at S161 is crucial for regulating cell death and inflammation. S161N mutation reduces RIPK1 kinase activity and prevents RIPK1-dependent keratinocyte death and skin inflammation, with combined mutations revealing functional interplay between S161 and S166 phosphorylation. https://hubs.la/Q03K_JMv0

Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang et al. reveal that RIPK1 S161 autophosphorylation promotes further a...
09/25/2025

Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang et al. reveal that RIPK1 S161 autophosphorylation promotes further autophosphorylation and is sufficient to substitute for RIPK1 kinase activity in TNF-induced necroptosis-mediated cecal damage and mouse death. https://hubs.la/Q03K-q1W0

Paul Kubes and Daniel Mucida have recently joined Journal of Experimental Medicine as Academic Editors Prof. Kubes is th...
09/25/2025

Paul Kubes and Daniel Mucida have recently joined Journal of Experimental Medicine as Academic Editors Prof. Kubes is the Canada Excellence Research Chair in Immunophysiology and Immunotherapy at Queen’s University. His lab studies how myeloid cells integrate into healthy tissues and maintain homeostasis. Dr. Mucida, Professor at The Rockefeller University and HHMI Investigator, explores how the immune system associated with intestinal mucosae can generate efficient immune responses without jeopardizing its tolerance to innocuous antigens. Learn more in their bios: https://hubs.la/Q03KYn050

Effective tuberculosis control requires CD4+ T cell recognition of infected macrophages. Volodymyr Stetsenko, Daniel P. ...
09/24/2025

Effective tuberculosis control requires CD4+ T cell recognition of infected macrophages. Volodymyr Stetsenko, Daniel P. Gail, Stephen M. Carpenter et al. (Case Western Reserve University School of Medicine) show that TCR clonotypes from latently infected individuals demonstrate dominant but not exclusive recognition of infected macrophages, specificity for type VII secretion system substrates, and expression of canonical effector programs. https://hubs.la/Q03KNYyv0

The early immune mechanisms determining M. tuberculosis infection outcome are unclear. William J. Branchett, Anne O’Garr...
09/23/2025

The early immune mechanisms determining M. tuberculosis infection outcome are unclear. William J. Branchett, Anne O’Garra et al. (The Francis Crick Institute) reveal that type I signaling early during M. tuberculosis infection favors neutrophil swarming and limits CD4+ T cell–macrophage interactions in TB lesions, impeding TB disease control. https://hubs.ly/Q03KBHRZ0

Qing Chang, Jian-Fu Chen et al. (USC Center for Craniofacial Molecular Biology) identify lymphatic vasculature on the ou...
09/19/2025

Qing Chang, Jian-Fu Chen et al. (USC Center for Craniofacial Molecular Biology) identify lymphatic vasculature on the outer surface of the skull but not inside the skull bone marrow, and reveal skull channel and bone marrow heterogeneity varying by region and age. https://hubs.la/Q03K5K-t0

Alexandra Florescu, Michelle Zuo, Angela Wang, Jennifer L. Gommerman et al. (University of Toronto) investigate the temp...
09/19/2025

Alexandra Florescu, Michelle Zuo, Angela Wang, Jennifer L. Gommerman et al. (University of Toronto) investigate the temporal accumulation of immune cells within distinct meningeal compartments in an animal model of progressive and uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission . https://hubs.ly/Q03JZbs60

The signaling pathway linking invariant TCR to PLZF during iNKT cell development is not completely understood. Eri Ishik...
09/18/2025

The signaling pathway linking invariant TCR to PLZF during iNKT cell development is not completely understood. Eri Ishikawa, Sho Yamasaki et al. (大阪大学(The University of Osaka)find that PKD plays a pivotal role in this pathway through a transcription factor Ikaros. https://hubs.la/Q03JY-Ph0

Peer Review Week 2025 is an opportunity to recognize the essential role reviewers play in safeguarding scientific rigor ...
09/18/2025

Peer Review Week 2025 is an opportunity to recognize the essential role reviewers play in safeguarding scientific rigor and advancing discovery. We are grateful to the expert reviewers who contribute their time, insight, and thoughtful critiques. We deeply appreciate your collaboration with authors and editors to strengthen the research we publish.

This year’s theme, "Rethinking Peer Review in the AI Era," captures what most of the industry is discussing in private and public circles about artificial intelligence. The organizers have made available a list of events and materials, and we have been exploring right alongside our peers: https://hubs.la/Q03JZsyn0

While this week has focused on technology, we want to take a moment to thank the people behind the peer review process. Our position is that rigorous peer review demands direct accountability that only human reviewers can provide.

As a nonprofit journal, JEM will continue to approach new technologies while never losing sight of what makes us unique, which is that we are driven by people and the scientific communities we serve.

Joshua Hatterschide, Liheng Yang, & Carolyn Coyne reveal that human trophoblasts activate a DUX4-driven antiviral progra...
09/18/2025

Joshua Hatterschide, Liheng Yang, & Carolyn Coyne reveal that human trophoblasts activate a DUX4-driven antiviral program against herpesviruses, uncovering a non-IFN pathway that protects the placenta via DUX4-stimulated genes. https://hubs.ly/Q03JYkcl0

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and ...
09/17/2025

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. https://hubs.la/Q03JQfXV0

Fan Xing, Hui Zhang and colleagues (Sun Yat-sen University) develop a way to combine oncolytic virus & CAR-T therapy by ...
09/12/2025

Fan Xing, Hui Zhang and colleagues (Sun Yat-sen University) develop a way to combine oncolytic virus & CAR-T therapy by specifically loading VSV onto the surface of CAR-T cells. This can directly pre-activate CAR-T cells via cross-connection between viral particles and CAR moieties and induce immunological synapse formation: https://hubs.la/Q03J76YN0

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