Journal of Experimental Medicine

Journal of Experimental Medicine The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research.

Since its inception in 1896, the goal of The Journal of Experimental Medicine (JEM) has been to publish outstanding and enduring studies in medical biology. At a time when many leading publishing groups are establishing topic-specific journals, we believe it is critical to complement that approach by offering a distinguished venue for publication of studies that integrate disciplines within the fi

eld of pathogenesis. A distinctive editorial system supports this goal with an emphasis on exceptional service to our authors. Two groups of editors work hand-in hand: professional editors with strong scientific backgrounds, and full-time practicing scientists. At least one editor from each group evaluates the merits of each paper prior to external review. The editors convene weekly to discuss all papers with external referee comments, and reach rapid decisions without excessive requests for revision. Within the field of medical biology we focus both on human studies and diverse in vivo experimental models of human disease that address such topics as genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We welcome reports ranging from atomic-level analyses to clinical interventions that illustrate new mechanisms.

New review from Hrishi Venkatesh and Lawrence Fong (Fred Hutch) describes how tumor-reactive CD4 T cells are functionall...
08/07/2025

New review from Hrishi Venkatesh and Lawrence Fong (Fred Hutch) describes how tumor-reactive CD4 T cells are functionally impaired in , including similarities/differences with CD8 T cells, and how immunotherapies can help overcome this. https://hubs.la/Q03BNddH0

Lei Yuan, Chen D**g et al. reveal that ciliated cells play an immunoregulatory role in allergic asthma by constitutively...
08/05/2025

Lei Yuan, Chen D**g et al. reveal that ciliated cells play an immunoregulatory role in allergic asthma by constitutively expressing IL-17D, which limits monocyte recruitment to inflamed lungs. These findings may provide a basis for developing therapies for related lung diseases. https://hubs.la/Q03BkTFZ0

Glial cells and lipoproteins coordinate lipid and immune signaling to regulate CNS inflammation. Vini Tiwari and Mikael ...
08/05/2025

Glial cells and lipoproteins coordinate lipid and immune signaling to regulate CNS inflammation. Vini Tiwari and Mikael Simons review the relationship between lipid metabolism and inflammation and how disruptions in this interplay contribute to neurological disorders. https://hubs.la/Q03Bk_Td0

Our August issue is here! https://hubs.la/Q03zqDR10 The cover image is from Conlon et al. (https://hubs.la/Q03zqFXT0). I...
08/04/2025

Our August issue is here! https://hubs.la/Q03zqDR10 The cover image is from Conlon et al. (https://hubs.la/Q03zqFXT0). In this experiment, naïve OT-I T cells were adoptively transferred into congenic mice, which were 1 day later immunized in the footpad with OVA plus CpG; interconnected chains of draining lymph nodes (IC-LNs) were harvested 2 days after. The image depicts the staining of proximal draining lymph nodes using multiparameter quantitative confocal imaging: OT-I T cells are in pink, CD11c-expressing DCs are in purple, and CD64-expressing monocytes are in light blue. The image has been modified by the JEM editorial office.

Mieke Metzemaekers, Niels Rinzema, and Ralph Stadhouders review how memory T cells fight infections and cancer by retain...
07/31/2025

Mieke Metzemaekers, Niels Rinzema, and Ralph Stadhouders review how memory T cells fight infections and cancer by retaining epigenetic “memories” that enable the rapid reactivation of inflammatory genes. The authors also discuss how such epigenetic mechanisms may fuel T cell dysfunction in disease, including T cell exhaustion in cancer. https://hubs.la/Q03zNt250

Maggie Fu, Mehul Sharma, Michael Kobor, Stuart Turvey, Catherine Biggs et al. identify biallelic germline ASXL1 variants...
07/31/2025

Maggie Fu, Mehul Sharma, Michael Kobor, Stuart Turvey, Catherine Biggs et al. identify biallelic germline ASXL1 variants as the cause of a novel inborn error of immunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, and malignancy, expanding the spectrum of genetic causes underlying human immunodeficiencies.
https://hubs.la/Q03zN5vY0

Jun-Ge Shi, Hong-Bing Shu, Shu Li et al. identify the type I BMP receptors ALK2 and ALK3 as critical mediators of T cell...
07/30/2025

Jun-Ge Shi, Hong-Bing Shu, Shu Li et al. identify the type I BMP receptors ALK2 and ALK3 as critical mediators of T cell activation and activation-induced cell death. The roles of ALK2/3 in these processes are interdependent and independent of their BMP ligands. https://hubs.la/Q03zyyQR0

Benjamin Gern, Michael Gerner, Kevin Urdahl et al. show that the early interplay between neutrophils and CD4 T cells is ...
07/30/2025

Benjamin Gern, Michael Gerner, Kevin Urdahl et al. show that the early interplay between neutrophils and CD4 T cells is pivotal in determining TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance. https://hubs.la/Q03zwJFv0

Scientist-philosopher and former Journal of Experimental Medicine editor René Dubos (1901–1982) is the focus of a new e-...
07/30/2025

Scientist-philosopher and former Journal of Experimental Medicine editor René Dubos (1901–1982) is the focus of a new e-book from The Rockefeller University. The annotated bibliography by Carol Moberg covers his ideas on health, society, ecology, and humanity, all strikingly relevant today. Access the e-book: https://hubs.la/Q03zqVsp0
Dubos, a leading scientist and humanist of the 20th century, spent over five decades at RU. His work shaped modern understanding of antibiotics, environmental health, and the interconnectedness of life. This bibliography features over 1,000 annotated entries, from research articles to essays and unpublished manuscripts, offering deep insight into Dubos' evolving philosophy.
We hope you enjoy it and encourage you to share your thoughts in the comments.

Insights from Patrick Willems, Lyudmila Kovalchuke, and Francis Impens (Universiteit Gent): Leddy et al. (https://hubs.l...
07/29/2025

Insights from Patrick Willems, Lyudmila Kovalchuke, and Francis Impens (Universiteit Gent): Leddy et al. (https://hubs.la/Q03zlss90) present PathMHC, a computationally guided mass spectrometry approach that boosts the detection of pathogen immunopeptides presented on infected cells. https://hubs.la/Q03zlv370

📢 We are now accepting applications for the JEM Early Career Travel Award, providing support for grad students & early-c...
07/29/2025

📢 We are now accepting applications for the JEM Early Career Travel Award, providing support for grad students & early-career postdocs to participate in a scientific conference. This year, the award will support the attendance of the International Cytokine and Interferon Society's annual meeting ! Apply here 👉 https://hubs.la/Q03yQlZ60

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