02/07/2025
In a recent Brain Communications paper, BIRC researchers & collaborators Raj G Kumar, Enna Selmanovic, Natalie Gilmore, Lisa Spielman, Lucia M Li, Jeanne M Hoffman, Yelena G Bodien, Samuel B Snider, Holly J Freeman, Nicola L de Souza, Christine L Mac Donald, Brian L Edlow, and Kristen Dams-O’Connor used data from the LETBI Study to identify 4 distinct clinical phenotypes in chronic TBI.
The 4 phenotypes were: 1) mixed cognitive and mood/behavioral deficits 2) predominant cognitive deficits 3) predominant mood/behavioral deficits 4) few deficits across domains. Phenotypes were based on 41 clinical measures and validated through advanced clustering methods.
MRI data indicated that cognitive & mood/behavioral phenotypes were associated with reduced cortical volumes in specific brain networks compared to the phenotype with few deficits. These findings suggest promising imaging biomarkers and intervention targets for chronic TBI.
FULL ARTICLE: https://pmc.ncbi.nlm.nih.gov/articles/PMC12198765/