09/12/2025
Semaglutide and GI Side Effects—What You Really Need to Know
https://youtube.com/shorts/NOfTW6V1msQ
Let’s talk about something that more and more patients are bringing up lately—the GI side effects of semaglutide (a.k.a. Ozempic, Wegovy, Zepbound). These meds are making headlines for dramatic weight loss results—but behind the scenes, a lot of people are dealing with some not-so-glamorous side effects.
We’re seeing a rise in complaints like nausea, vomiting, constipation, diarrhea, bloating, and even reflux. And for some people, it’s not just a little tummy trouble—it can be enough to stop the meds altogether. Here’s why: semaglutide slows down your digestion—intentionally. That’s part of how it helps with weight loss. You feel fuller longer, you eat less. But that slowdown can also wreak havoc on your GI system.
I tell my patients this all the time: Weight loss should never come at the cost of your quality of life. If you’re constantly nauseated or can’t keep food down, it’s time to re-evaluate your dosing, timing, or even if this medication is right for you.
The good news? There are ways to manage these symptoms. Smaller meals, more water, slowing your dose escalation, and sometimes adding supportive meds. But the most important thing is that you’re honest with your provider about what you're feeling. Don’t suffer in silence.
And if you’re thinking about surgery while on these meds? That’s a whole other conversation—we’ve already talked about pausing them pre-op to protect your safety under anesthesia. So yes, these drugs are powerful. But they’re not perfect. And they definitely need to be used with expert guidance.
If you’re struggling with side effects or just unsure what’s normal, reach out. We’re here to help you navigate this safely and comfortably—because the goal isn’t just weight loss. It’s wellness.
Dr. Sam Speron