Lexi Yoo, FNP, IFMCP

04/11/2026

You can get peptides online.
You can also get sushi from a gas station.
I’m sure this gonna trigger someone but I’m gonna say it! Especially after this weekend conference talking peptides and longevity medicine!

❌Accessibility doesn’t equal safety and that distinction matters more than ever right now.

Peptides are not the problem.
Unstructured, unsupervised use is.

Here’s what often gets missed:

🧪 Source matters — Not all peptides are regulated, verified, or consistent in purity
📉 Dosing isn’t guesswork — Too much too fast is where most side effects come from
🧠 Your physiology matters — Metabolic health, nutrition, and history change response
⚠️ Side effects need context — Nausea, fatigue, and GI issues are often preventable with proper strategy
😳 who shouldn’t take certain peptides? Yes the list is small but should be considered.

And that’s where people run into trouble.

This isn’t about gatekeeping.
It’s about outcomes.

👉🏼Share one someone who needs to hear this!
Where’s the craziest place you’ve heard someone getting peptides?
🚩someone’s mailbox
🚩their personal trainer
🚩their chiropractor
🚩their hair salon

04/10/2026

🎙️Packed house at the regenerative medicine track! I hope you enjoyed my fast and furious Lecture on peptides, hormones and longevity medicine! I’m sure I left you with so many questions and take home thoughts.

📚 If you want to learn more about training with me, check out or shoot me a dm.
Let me know you were at AMSPA!

04/09/2026

𝗢𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗯𝗶𝗴𝗴𝗲𝘀𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗴𝗮𝗽𝘀 𝗜 𝘀𝗲𝗲 𝘄𝗶𝘁𝗵 𝗛𝗮𝘀𝗵𝗶𝗺𝗼𝘁𝗼’𝘀 𝗶𝘀 𝘁𝗵𝗶𝘀:
🦋 Patients are told everything is “normal” because their TSH is in range, while their antibodies are elevated and symptoms are progressing.

❌That’s not a thyroid problem. That’s an immune problem.

🧠 Hashimoto’s is an autoimmune condition, not just hormone dysfunction
🧪 Antibodies often rise years before TSH becomes abnormal
🦠 Gut dysfunction is one of the most common upstream triggers
🔥 Chronic inflammation keeps the immune system activated
⚖️ 𝗣𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗮𝗺𝗽𝗹𝗶𝗳𝗶𝗲𝘀 𝗶𝗺𝗺𝘂𝗻𝗲 𝗮𝗻𝗱 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗶𝗻𝘀𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆

👉🏻𝘛𝘩𝘪𝘴 𝘪𝘴 𝘸𝘩𝘺 𝘴𝘰 𝘮𝘢𝘯𝘺 𝘸𝘰𝘮𝘦𝘯 𝘧𝘦𝘦𝘭 𝘥𝘪𝘴𝘮𝘪𝘴𝘴𝘦𝘥.
Their labs look “fine” on paper, but no one is evaluating the immune activity behind the scenes.

𝗔𝗻𝗱 𝗵𝗲𝗿𝗲’𝘀 𝘁𝗵𝗲 𝗸𝗲𝘆 𝗺𝗶𝘀𝗰𝗼𝗻𝗰𝗲𝗽𝘁𝗶𝗼𝗻:
👉 If your TSH is normal, your thyroid is fine.
Not true.

You can have active autoimmune thyroid disease with completely “normal” standard labs.

⬆️ If antibodies are elevated, something is driving that immune response, and until that’s addressed, symptoms often persist.

After checking labs, my next move is an advanced gut test, like a GI MAP! From there I help patient formulate a plan that works best from them to include nutrition and a curated supplement regimen.

𝗜𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗲𝗱 𝗶𝗻 𝘁𝗵𝗲 𝘀𝘂𝗽𝗽𝗹𝗲𝗺𝗲𝗻𝘁𝘀 𝗜 𝘂𝘀𝗲 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝗹𝗹𝘆 𝘄𝗶𝘁𝗵 𝗺𝘆 𝗛𝗮𝘀𝗵𝗶 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀?
🔗Comment 𝗛𝗔𝗦𝗛𝗜 to get the link sent to your DM!

04/09/2026

𝗪𝗵𝗲𝗿𝗲 𝗜’𝗺 𝘀𝗽𝗲𝗮𝗸𝗶𝗻𝗴 𝗻𝗲𝘅𝘁 ✨

I’m so excited to connect, teach, and help shape the future of regenerative aesthetics, peptides, wellness and metabolic health this year. 𝘏𝘦𝘳𝘦’𝘴 𝘸𝘩𝘦𝘳𝘦 𝘺𝘰𝘶 𝘤𝘢𝘯 𝘧𝘪𝘯𝘥 𝘮𝘦:

📍 𝗔𝗠𝗦𝗣𝗔
📅 April 10
📌 Wynn, Las Vegas
🎤 Regenerative Aesthetics: Longevity, Peptides, and Metabolic Health

📍 𝗧𝗵𝗲 𝗔𝗲𝘀𝘁𝗵𝗲𝘁𝗶𝗰 𝗦𝗵𝗼𝘄
📅 June 26–27
📌 Wynn, Las Vegas
🎤 Updates in Ge***al Aesthetic Treatments
🎤 INTEGRATIVE AESTHETICS SYMPOSIUM- Your Hormone Replacement Primer

📍 𝗔𝗲𝘀𝘁𝗵𝗲𝘁𝗶𝗰 𝗡𝗲𝘅𝘁
📅 September 10
📌 Dallas, Texas
🎤 Topic: TBD

📍 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗔𝗲𝘀𝘁𝗵𝗲𝘁𝗶𝗰 𝗔𝗿𝘁 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲
📅 September 18–20
📌 Park City, Utah
🎤 Peptides + business protocols for integrating peptides & hormones
🎤 Day 2: The business of peptide therapy

𝘊𝘰𝘮𝘦 𝘭𝘦𝘢𝘳𝘯, 𝘤𝘰𝘯𝘯𝘦𝘤𝘵, 𝘢𝘯𝘥 𝘦𝘭𝘦𝘷𝘢𝘵𝘦 𝘺𝘰𝘶𝘳 𝘱𝘳𝘢𝘤𝘵𝘪𝘤𝘦 💫

𝗪𝗵𝗶𝗰𝗵 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀 𝘄𝗶𝗹𝗹 𝘆𝗼𝘂 𝗯𝗲 𝗵𝗲𝗮𝗱𝗲𝗱 𝘁𝗼 𝘁𝗵𝗶𝘀 𝘆𝗲𝗮𝗿?

04/08/2026

𝗣𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗶𝘀 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗺𝗶𝘀𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗼𝗼𝗱 𝗵𝗼𝗿𝗺𝗼𝗻𝗲𝘀 𝗜 𝘀𝗲𝗲 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹𝗹𝘆.
✋🏻Interested in learning more about the benefits beyond fertility, uterus, pms, or Pmdd?
🔗 Check out my latest substack article where I break down the research!
♥️ 𝗖𝗢𝗠𝗠𝗘𝗡𝗧: 𝘀𝘂𝗯𝘀𝘁𝗮𝗰𝗸 to get the link!

Why is progesterone isolated to just the bikini areas? Uterus, pms, pmdd, and fertility...
❌ Not because it’s complicated but because in traditional medicine it’s been reduced to fertility, PMS, and “uterine protection.”

𝘛𝘩𝘢𝘵’𝘴 𝘢𝘯 𝘪𝘯𝘤𝘰𝘮𝘱𝘭𝘦𝘵𝘦 𝘱𝘪𝘤𝘵𝘶𝘳𝘦.
🧠Progesterone is a neuroactive, anti-inflammatory, and regulatory hormone that impacts far more than the menstrual cycle.

𝗛𝗲𝗿𝗲’𝘀 𝘄𝗵𝗮𝘁 𝗺𝗮𝘁𝘁𝗲𝗿𝘀 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹𝗹𝘆:
• 🧠 It modulates GABA → sleep, anxiety, nervous system tone
• 🔥 It helps counterbalance inflammatory signaling
• ⚖️ It stabilizes estrogen effects (not just “low vs high”)
• 🌙 It plays a major role in sleep quality and recovery

𝗔𝗻𝗱 𝘁𝗵𝗶𝘀 𝗶𝘀 𝘄𝗵𝗲𝗿𝗲 𝗺𝗶𝘀𝘁𝗮𝗸𝗲𝘀 𝗵𝗮𝗽𝗽𝗲𝗻:
Most progesterone labs are drawn at the wrong time, interpreted without context, or dismissed entirely when they don’t match symptoms. 𝗧𝗼 𝗯𝗲 𝗵𝗼𝗻𝗲𝘀𝘁: SERUM PROGESTERONE in most patients gives me very little insight to what is actually happening at the cell when they are on progesterone!

👉🏻A “normal” value doesn’t mean optimal signaling.
Especially in perimenopause, where progesterone becomes erratic before it becomes low.

This is why I don’t treat numbers alone, I treat the patient in front of me, and I treat physiology.

If you’ve been told your hormones are “fine” but still feel off…
this is often part of the missing conversation.

And if you’ve ever been told progesterone is only for your cycle, its time your learn to decode your own labs!

💻 Be on the look out for the launch of my new website www.lexiyoonp.com and my self guided course on navigating perimenopause and interpreting your own labs!

04/08/2026

💉𝗜𝗳 𝗶𝘁’𝘀 𝗮 𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁, 𝗶𝘁 𝗿𝗲𝗾𝘂𝗶𝗿𝗲𝘀 𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗼𝘃𝗲𝗿𝘀𝗶𝗴𝗵𝘁. 𝗡𝗼 𝗲𝘅𝗰𝗲𝗽𝘁𝗶𝗼𝗻𝘀.

➡️In aesthetics and longevity care, this line gets blurred.

👉🏻Procedures like neurotoxins, microneedling, and energy-based devices aren’t just “cosmetic.” They are classified as medical treatments in every state.

That means one thing: someone qualified to diagnose and prescribe must be involved.

This isn’t a formality. It’s the foundation of safe care.

🤔𝗔 𝗽𝗿𝗼𝗽𝗲𝗿 “𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗰𝗹𝗲𝗮𝗿𝗮𝗻𝗰𝗲” 𝗶𝘀𝗻’𝘁 𝗷𝘂𝘀𝘁 𝗽𝗮𝗽𝗲𝗿𝘄𝗼𝗿𝗸, 𝗶𝘁’𝘀 𝗮 𝗱𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗺𝗮𝗱𝗲 𝗯𝘆 𝘀𝗼𝗺𝗲𝗼𝗻𝗲 𝘁𝗿𝗮𝗶𝗻𝗲𝗱 𝘁𝗼 𝗲𝘃𝗮𝗹𝘂𝗮𝘁𝗲 𝗿𝗶𝘀𝗸, 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝘁𝗵𝗲 𝗿𝗶𝗴𝗵𝘁 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁, 𝗮𝗻𝗱 𝘁𝗮𝗸𝗲 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗼𝘂𝘁𝗰𝗼𝗺𝗲.

Without that step, the entire process is missing its core safeguard.

💡As these treatments become more popular, the question isn’t what’s trending—it’s who is actually making the medical decisions behind the scenes.

📌Follow @‌lexiyoonp for more education.

𝘈𝘳𝘦 𝘵𝘩𝘦𝘴𝘦 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵𝘴 𝘣𝘦𝘪𝘯𝘨 𝘵𝘳𝘦𝘢𝘵𝘦𝘥 𝘵𝘰𝘰 𝘤𝘢𝘴𝘶𝘢𝘭𝘭𝘺? 𝘖𝘳 𝘪𝘴 𝘵𝘩𝘦 𝘴𝘺𝘴𝘵𝘦𝘮 𝘰𝘷𝘦𝘳𝘤𝘰𝘮𝘱𝘭𝘪𝘤𝘢𝘵𝘪𝘯𝘨 𝘢𝘤𝘤𝘦𝘴𝘴 𝘵𝘰 𝘤𝘢𝘳𝘦? 𝘞𝘩𝘰 𝘴𝘩𝘰𝘶𝘭𝘥 𝘣𝘦 𝘪𝘯 𝘤𝘩𝘢𝘳𝘨𝘦 𝘰𝘧 𝘥𝘦𝘤𝘪𝘥𝘪𝘯𝘨 𝘸𝘩𝘢𝘵’𝘴 “𝘴𝘢𝘧𝘦”?

04/07/2026

Fatigue in perimenopause is rarely just a “low NAD” issue.

And if you’ve tried NAD and felt… off? You’re not alone.

💡 Many women report chest tightness, flushing, or a wired feeling
💡 That’s not a sign to just push through because it’s working so good 😳
💡 NAD pushes energy pathways… but doesn’t fix upstream dysfunction

In perimenopause, we’re dealing with shifts in mitochondrial function, metabolic signaling, and hormone-driven energy regulation 👇🏻not just depletion 

👑That’s why I often consider other compounds first:
You’re gonna want to save this list 💾
🧠 Methylene blue → supports mitochondrial efficiency + cognitive clarity ❤️ I take this 5 days a week
🔥 5-amino (5-Amino-1MQ) → influences fat metabolism + NAD pathways! Also take this 5 days a week to work on the NAD salvage pathway!
⚡ MOTS-c → peptide that improves insulin sensitivity + cellular energy signaling. Cycle this with all my other peptides periodically.

These target the system driving the fatigue not just the end product.

Then NAD can work better… and feel better.

🤓This is the difference between pushing energy vs restoring how your body makes it.

You’re not “failing” NAD.
You may just be skipping steps.

📌Follow for continued clinical education on perimenopause + longevity.
💾Save this so you can come back to it.

Have you tried NAD? If so, what did you think about the chest tightness. Love it or hate it?
I personally did not love it.

04/06/2026

Did you catch today’s episode of 𝗧𝗵𝗲 𝗕𝗲𝘁𝘁𝗲𝗿 𝗬𝗼𝗼 𝗣𝗿𝗼𝗷𝗲𝗰𝘁 𝗽𝗼𝗱𝗰𝗮𝘀𝘁, where I sit down with Alex Thiersch, JD, president of AmSpa, to talk about the legalities and regulatory changes shaping the medspa industry?

One thing we both agreed on:
𝗬𝗼𝘂 𝗰𝗮𝗻’𝘁 𝗵𝗮𝘃𝗲 𝗮𝗻 “𝗮𝗯𝘀𝗲𝗻𝘁𝗲𝗲 𝗹𝗮𝗻𝗱𝗹𝗼𝗿𝗱” 𝗮𝘀 𝗮 𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗱𝗶𝗿𝗲𝗰𝘁𝗼𝗿.
👉🏻If someone is listed as a medical director but isn’t truly trained in aesthetics, and is “overseeing” dozens of providers across a state they can’t realistically supervise… that’s a problem.

𝗔 𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗱𝗶𝗿𝗲𝗰𝘁𝗼𝗿 𝗶𝘀𝗻’𝘁 𝗷𝘂𝘀𝘁 𝗮 𝘁𝗶𝘁𝗹𝗲. 𝗜𝘁’𝘀 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗶𝗯𝗶𝗹𝗶𝘁𝘆.
It means:
• Understanding the treatments being performed
• Ensuring providers are properly trained and qualified
• Being actively involved in patient safety and outcomes

𝗛𝗮𝗿𝗱 𝘁𝗿𝘂𝘁𝗵: It’s more than just collecting a paycheck or a retirement plan!

𝗧𝗵𝗲 𝗶𝗻𝗱𝘂𝘀𝘁𝗿𝘆 𝗶𝘀 𝘀𝗵𝗶𝗳𝘁𝗶𝗻𝗴. 𝗘𝘅𝗽𝗲𝗰𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗵𝗶𝗴𝗵𝗲𝗿. 𝗔𝗻𝗱 𝗮𝗰𝗰𝗼𝘂𝗻𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗺𝗮𝘁𝘁𝗲𝗿𝘀 𝗺𝗼𝗿𝗲 𝘁𝗵𝗮𝗻 𝗲𝘃𝗲𝗿.

If you’re building or part of a medspa, this is a conversation you need to hear.
Comment 𝗠𝗘𝗗𝗦𝗣𝗔 and I’ll send you the link to the full episode

𝗜𝗳 𝘆𝗼𝘂’𝗿𝗲 𝗮𝗻 𝗶𝗻𝗷𝗲𝗰𝘁𝗼𝗿, 𝘄𝗵𝗮𝘁 𝗮𝗿𝗲 𝘆𝗼𝘂𝗿 𝘁𝗵𝗼𝘂𝗴𝗵𝘁𝘀?
➡️ Should medical directors also be trained in Aesthetics to be the medical director?

And if you’re attending 👇
𝗖𝗮𝘁𝗰𝗵 𝘂𝘀 𝗯𝗼𝘁𝗵 𝘀𝗽𝗲𝗮𝗸𝗶𝗻𝗴 𝗮𝘁:
🎤The Medical Spa Show
Wynn Las Vegas
April 9–12, 2026

04/06/2026

Happy Easter!
-The Yoos!

04/04/2026

Why Dutch testing?

Advanced Hormone Metabolite Testing with DUTCH | Dr. Brooke Ahnemann & Lexi Yoo, NP | CALM 2026At the Clinical Application of Longevity Medicine 2026 confere...

04/04/2026

Not all GLP-1–based medications produce the same amount of weight loss.

And the differences are clinically meaningful.

📊 Here’s a simplified breakdown from major trials:

Orforglipron (oral GLP-1)
• ~11% average weight loss
• ~72 weeks
• Dose-dependent response 

Semaglutide (GLP-1)
• ~12–15% average weight loss
• ~68 weeks
• STEP trial data

Tirzepatide (GLP-1 + GIP)
• ~15–22% average weight loss
• ~72 weeks
• SURMOUNT trials

⚖️ Important context:

These are not head-to-head trials, so exact comparisons have limits.
But the pattern is consistent.

🧠 Why the difference?

• Semaglutide → single GLP-1 pathway
• Tirzepatide → dual incretin effect (GLP-1 + GIP) → greater metabolic impact
• Orforglipron → same GLP-1 receptor, but oral delivery and slightly lower overall effect size

So where does that leave orforglipron?

👉 Slightly less weight loss
👉 Much easier administration

No injections. No refrigeration. Simpler adherence.

That tradeoff may matter more than people think.

❤️Follow along if you want clearer conversations about GLP-1s and metabolic health.
💾 Save this so you can compare options later.

Question: If you’re considering treatment, what matters more to you, maximum weight loss or ease of use?