Coastal Carolinas Integrated Medicine

Coastal Carolinas Integrated Medicine https://www.carlywilleford.com Dr. Willeford obtained his degree in physics, and started his career as a research physicist. Dr. Kenneth L.

He then went on to complete medical school, and then completed training as an Anesthesiologist and Board Certification in both Anesthesia and Interventional Pain Management. Dr. Willeford currently has 5 patents which are issued and pending in the fields of medical devices and pharmaceuticals. Willeford is the Owner and Medical Director of Coastal Carolinas Integrated Medicine. The Interventional Pain Management Center and Program is located in our North Office at 10 Doctors Circle, Suite 2 Supply, N.C. Dr. Carly Willeford aka "The Raw Doctor" received her Doctorate Degree from USC. The Doctor of Nursing Practice (DNP) is an advanced-level practice, terminal degree that focuses on the clinical aspects of nursing. Dr. Carly is an expert at planning and implementing preventative health care strategies with individuals and populations. Dr. Carly integrates the spiritual, biological, social, psychological and cultural factors into the healthcare model to influence healthy responses to illness. The goal of a DNP Nurse Practitioner medical practice, in addition to providing excellent care to patients, is to optimize health care delivery through effective planned change. The changing demands of this nation's complex healthcare environment require the highest level of scientific knowledge and practice expertise to assure quality patient outcomes.

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Substance Abuse & N-Acetylcysteine (NAC) — what the evidence shows!

N-acetylcysteine (NAC) is a precursor to glutathione, the brain’s major antioxidant. Over the last 15–20 years it’s been studied as an adjunct (not a stand-alone cure) for several substance-use disorders because it targets craving biology, not just symptoms.



How NAC helps (mechanisms that matter in addiction)

1. Normalizes glutamate signaling
Addiction dysregulates glutamate in the nucleus accumbens (reward hub). NAC restores the cystine–glutamate exchanger, helping quiet the compulsive “wanting” signal that drives relapse.

2. Reduces craving & cue-reactivity
People often relapse when exposed to cues (stress, places, people). NAC dampens this cue-induced glutamate surge.

3. Antioxidant & neuroprotective
Substances increase oxidative stress and neuroinflammation. By replenishing glutathione, NAC supports neuronal recovery—important in long-term healing.

4. Improves impulse control (indirectly)
By stabilizing reward circuits, some users experience fewer compulsive urges (also studied in OCD-spectrum behaviors).

Substances with the best evidence:

Substance / Behavior
Evidence summary

Cannabis
↓ craving, ↓ use, better abstinence rates (especially in adolescents/young adults)
Co***ne
↓ craving and relapse risk (mixed but promising)
Alcohol
↓ craving, supports liver health; best as adjunct to counseling
Ni****ne
Mixed results; modest craving reduction in some
Gambling / compulsive behaviors
Benefits seen via similar reward-circuit mechanisms

NAC works best between detox and relapse prevention, not for acute withdrawal.



Practical dosing (clinical ranges used in studies)
• Typical dose: 1,200–2,400 mg/day
(often split 600–1,200 mg twice daily)
• Duration: 8–24 weeks minimum
• Form: Capsules or powder; take away from food if GI upset occurs



Safety & considerations
• Generally very safe, OTC
• Possible side effects: mild GI upset, sulfur smell
• Use caution with:
• Active asthma (rare bronchospasm)
• Nitroglycerin (can potentiate vasodilation)
• Not addictive and non-sedating



What NAC does not replace
• Counseling / behavioral therapy
• Trauma-informed care
• Social support, sleep, nutrition, exercise

Think of NAC as biochemical scaffolding while the brain relearns healthier reward patterns.



Where this fits for patients

• Repeated relapse despite “willpower”
• High cue-reactivity and stress-triggered use
• Co-existing gut inflammation or oxidative burden
NAC is a low-risk, high-upside adjunct that aligns well with functional and neuro-root-cause ml

Address

416 Main Street
North Myrtle Beach, SC
29582

Opening Hours

Monday 9am - 5pm
Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 8am - 12am

Telephone

+19107556060

Website

http://NMBmedicalmall.com/, https://ccimnurse.janeapp.com/

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Our Story

Dr. Willeford obtained his degree in physics, and started his career as a research physicist. He then went on to complete medical school, and then completed training as an Anesthesiologist and Board Certification in both Anesthesia and Interventional Pain Management. Dr. Willeford currently has 5 patents which are issued and pending in the fields of medical devices and pharmaceuticals. Dr. Kenneth L. Willeford is the Owner and Medical Director of Coastal Carolinas Integrated Medicine. The Interventional Pain Management Center and Treatment Program is located in at 10 Doctors Circle, Suite 2 Supply, N.C. Dr. Carly Willeford received her Doctorate Degree from the University of South Carolina specializing in Psychiatry and Acute Care. Dr. Carly attended the University of North Carolina, Wilmington and received her Masters in Science and Family Nurse Practitioner Degree (FNP). Dr. Carly attended The Catholic University of America, Washington DC and received her Bachelors of Nursing Degree (BSN) as well as attended Mansfield University, Pennsylvania and obtain a Bachelors degree in Social Work and Counseling (BSW). Dr. Carly Willeford worked at as a Social Worker and Mental Health Therapist before entering the medical profession.

The Doctor of Nursing Practice (DNP) is an advanced-level practice, terminal degree that focuses on the clinical aspects of nursing. Dr. Carly’s passion is planning and implementing preventative health care strategies with individuals and populations by integrating spiritual, biological, social, psychological and cultural factors to influence healthy responses to illness.

The goal of the Willefords’ is to provide excellent care and optimize health care delivery through effective planned change. The changing demands of this nation's complex healthcare environment require the highest level of scientific knowledge and practice expertise to assure quality patient outcomes.

The Willefords are parents to 6 awesome kids!