Bio-SANS user community

11/11/2022

New tool for your to use SANS data:

The 3D structure of biomacromolecules, such as protein and DNA/RNA, provide keys to understanding their biological functions. Among many structural bi…

08/26/2022

https://anl.us17.list-manage.com/track/click?u=cf3ed56636b3937a7799bf9d3&id=45b7ecd10d&e=b7df715eb7

07/20/2022

https://www.sciencedirect.com/science/article/abs/pii/S0005272822000652

The use of styrene-maleic acid copolymers (SMAs) to produce membrane protein-containing nanodiscs without the initial detergent isolation has gained s…

06/27/2022

The future:
https://neutrons.ornl.gov/centaur

05/20/2022

https://neutrons.ornl.gov/content/mystery-mechanism-small-peptide-shows-big-promise-fighting-antibiotic-resistance-bacteria

Since the advent of penicillin more than 90 years ago, antibiotic drugs have saved countless lives by preventing and treating bacterial infections. However, bacteria are rapidly developing new ways to resist antibiotics, making some of modern medicine’s most powerful drugs less effective against m...

03/28/2022

Small Angle Scattering Seminar Series: https://small-angle.aps.anl.gov/seminarsSpeaker: William Heller, Oak Ridge National LaboratoryAbstract:Oak Ridge Natio...

03/22/2022

https://youtu.be/FPE7LGeb4bY

03/11/2022

A nice new tool to try
https://www.biorxiv.org/content/10.1101/2022.03.01.478978v1

Small-angle neutron scattering (SANS) provides easily manipulable neutron contrast variation that has been widely exploited to study the structure and function of biological macromolecules and their complex in solution. Here, we developed a method called DENSS-Multiple based on the DENSS (DENsity fr...

01/21/2022

https://neutrons.ornl.gov/content/reshaping-world-research-through-remote-experimentation

We all remember the impact of stay-at-home-orders on our everyday lives in spring 2020. However, it was not only restaurants, salons, flower shops, and bookstores that had to close their doors. National user research facilities shut down most operations, closing the doors to thousands of visiting sc...

01/07/2022

https://neutrons.ornl.gov/content/ornl%E2%80%99s-top-10-science-achievements-sns-and-hfir-2021

The Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL) operates two of the world’s most powerful sources of neutrons for research – the Spallation Neutron Source (SNS) and the High Flux Isotope Reactor (HFIR).

12/17/2021

Neutron is always useful for locating H.

Scientists with the European Space Agency have just discovered 'significant' volumes of water in its grand canyon system! This is a major find.

12/15/2021

The boundaries of cells and many organelles are marked by membranes—layers of lipids and proteins. Along with providing structure, membranes import nutrients, support communication, and play an important role in energy production. Learn more about the marvels of membranes in our latest Biomedical Beat blog post. https://go.usa.gov/xe6J2

04/24/2021

Interested in Neutrons but need to know the basics? Visit our website and learn something new! 🤓

https://buff.ly/32KlM1s

04/06/2021

Another good platform for membrane protein: Structure of Diisobutylene Maleic Acid Copolymer (DIBMA) and Its Lipid Particle as a “Stealth” Membrane-Mimetic for Membrane Protein Research
https://pubs.acs.org/doi/full/10.1021/acsabm.0c01626

The study of membrane proteins remains challenging, especially in a native membrane environment. Recently, major progress has been made using maleic acid copolymers, such as styrene maleic acid, to purify membrane proteins and study them directly with native lipids associated with the membrane. Addi...

03/27/2021

Call for contributions!
https://www.mdpi.com/journal/applsci/special_issues/biological_small_angle_scattering

Special Issue in journal Applied Sciences: Biological Small Angle Scattering Techniques and Applications

12/10/2020

A guide to use neutron scattering to study membrane related research:
https://pubs.acs.org/doi/full/10.1021/acs.langmuir.0c02516

The membrane is one of the key structural materials of biology at the cellular level. Composed predominantly of a bilayer of lipids with embedded and bound proteins, it defines the boundaries of the cell and many organelles essential to life and therefore is involved in almost all biological process...

09/28/2020

You can get both X-ray and neutron beam time at Bio-SANS instrument!
https://www.bnl.gov/newsroom/news.php?a=217454&fbclid=IwAR2MkCFPxbb_S-8AusP9CTHPSu7g7TKApgpYTlSq8nCqLeJXiKLvCxjf0dw

X-rays at Brookhaven Lab and neutrons at Oak Ridge confirm structure of artificial membrane that can be used to study how lipids affect proteins

09/25/2020

https://neutrons.ornl.gov/content/novel-cell-membrane-model-could-be-key-uncovering-new-protein-properties

The cell membrane, the wall-like boundary between the cell interior and its outside environment, is primarily made up of two kinds of biomolecules: lipids and proteins. Different lipid species closely pack together to form a double layer, or “bilayer,” the membrane’s fundamental structure, whi...