07/29/2025
Min Li, Ph.D., a professor of medicine, surgery and cell biology at The University of Oklahoma College of Medicine and his research team have uncovered why glioblastoma, the most aggressive form of brain cancer, is so hard to treat.
In a new study published in Proceedings of the National Academy of Sciences (PNAS), scientists uncovered the role of a protein called ZIP4 in fueling glioblastoma:
▪️ZIP4 causes tumors to absorb too much zinc
▪️It sends out tiny “packages” that confuse the brain’s immune cells — turning them into tumor helpers instead of fighters
▪️This speeds up tumor growth and makes treatment more difficult
The breakthrough? Researchers tested a new compound that blocks ZIP4 and another protein called TREM1, slowing tumor growth in lab studies.
This discovery could lead to new, more effective treatments for glioblastoma and possibly other cancers like pancreatic cancer. It’s a hopeful step toward giving patients better options and outcomes and a powerful example of the joint clinical, research, and educational missions of OU Health and the University of Oklahoma. By combining world-class patient care, advanced science, and the training of future physicians, we are leading the way in the fight against cancer.
Dr. Ian Dunn, OU Health neurosurgeon, professor and Executive Dean at the OU College of Medicine, who co-authored the study said, “The hope and promise is to translate these findings to novel treatment approaches to improve the lives of our patients.”