Trugenex / PLN

11/18/2025

Trugenex is now offering our patients RIMAN for a Clean, Non-Toxic regimen to skincare.
Christmas gifts to your Friends an Family!!!!

11/16/2025

We are giving back 30% OFF to get started on a plan to a Better Quality of Life that isn't filed with bandaids and treating lab markers.
At Trugenex we get to the root of your symptoms.
CALL NOW (405)245-9475

08/20/2025

With Prof. Valter Longo – I just made it onto their weekly engagement list by being one of their top engagers! 🎉

08/17/2025

🇺🇸 “Fasting and the Longevity Revolution”

A documentary by Academy Award nominees Barry Alexander Brown, Edward Norton, and Chiara Tilesi, inspired by Dr. Valter Longo’s books. Nutrition plays a key role in longevity. Beyond genetics, dietary and lifestyle choices have a strong impact on long-term health. From Calabria to the highlands of Ecuador, a journey to discover how to live longer and healthier.

Available On-Demand in ENGLISH at https://www.fastingandthelongevityrevolution.com/

Coming soon: Dubbed in Italian and with subtitles in more than 10 languages

By purchasing the documentary, you support the mission and non-profit projects of the Create Cures Foundation.

For information and nutritional assistance, contact the Create Cures Foundation at the following email: clinic@createcures.org

Chiara Tilesi

08/14/2025

If you are interested in Fasting, Intermittent Fasting or Fasting Mimicking Diets. Valter Longo Phd is the man with patent. Learn from the actual scientist that uncovered these benefits. STOP the swipe up fear social media creates and learn from the experts.

🇬🇧 Rizzola Magazine | Valter Longo: “A longer life, but above all a healthier one”

A journey through stories of healing and discovery, from the upcoming podcast to the fasting-mimicking diet, which has shown potential in promoting cellular regeneration, improving olfactory function, and supporting patients with diabetes and chronic kidney disease. In this interview, Prof. Valter Longo brings together science, personal experience, and a passion for music to discuss health, innovation, and the future of longevity.

Watch the interview available in English translated by AI: https://www.youtube.com/watch?v=HxRXjjffuK8

AI Translation in English

For information and nutritional assistance, contact the Create Cures Foundation at: clinic@createcures.org

08/12/2025

❓Did you know?
Your🧬DNA holds the🔑keys to your wellness!

🕵️‍♀️Find out what you need on a genetic level.
🧐Find out what hereditary diseases you're susceptible to and how to possibly prevent them!
This🧪test comes with a nutritional plan geared specifically for your DNA, meal plans, exercise plan, an app to order your groceries through, and what to order at restaurants.

📲call (405)245-9475 today to schedule a virtual or in-person visit to learn more!
🔖Get a discount on your visit when you mention this post

07/31/2025

⁉️Did you know that when patients have these symptoms a lab is not performed on them? Typically, a💊medication is prescribed.

A neurotransmitter test is crucial to finding the direct cause of mental🧠health issues. After we run this lab🧪on patients, we have a specific diagnoses for them as well as a more natural way of treating it.

📲Call (405)245-9475 today to schedule a virtual or in-person consultation.
🗣Mention this post and get a🔖discount on your visit!

07/16/2025

‼️Test don't guess!🧐Find out about your🧬genetics, and the role they play in your💪nutrition. Learn about what hereditary diseases you're susceptible to, and how to possibly prevent them!
📲Call (405)245-9475 today to schedule with a🔖discount on your visit for mentioning this post.

07/16/2025

Take advantage of our affordable primary care option with unlimited access to our physician!

07/15/2025

Shared with Dropbox

07/15/2025

Immune tumor microenvironment role in cancer

Metastasis is driven by context dependent tumor–immune interactions that shift between suppressing and promoting cancer based on spatial and temporal cues in the microenvironment.

The immune tumor microenvironment (TME) shapes metastasis through balancing its pro- and antitumor roles in extracellular matrix (ECM) remodeling, immune suppression, angiogenesis, and T cell exclusion.

Circulating tumor cells (CTCs) are protected and supported by neutrophils and macrophages in the circulation that help them to survive immune surveillance and mechanical stress, which enables their metastasis to distant sites.

The pre-metastatic niche (PMN) is shaped by immune and stromal interactions in which monocytes and neutrophils drive immunosuppression, inflammation, and ECM remodeling to prime distant organs for metastasis, emphasizing the need for site specific immune-targeted therapies .

Disseminated tumor cells (DTCs) face intense immune and microenvironmental pressures at secondary sites where they often enter dormancy to evade detection and survive, but can later escape this state through immune evasion, ECM remodeling, or inflammatory cues – highlighting the need for therapies that target both immune responses and dormancy pathways to prevent metastatic relapse.

The metastatic TME influences DTCs through immune and inflammatory interactions that can either maintain dormancy or trigger reactivation, and treatments such as surgery and chemotherapy sometimes promote metastasis, emphasizing the need for therapies.

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00124-2
https://sciencemission.com/immune-tumor-microenvironment