Margarita Correa MD CLT - Lymphedema / Lipedema Physician

12/18/2025

💙 𝘾𝙤𝙢𝙥𝙤𝙪𝙣𝙙𝙚𝙙 𝙂𝙇𝙋-1 𝙈𝙚𝙙𝙞𝙘𝙖𝙩𝙞𝙤𝙣𝙨 (𝙎𝙚𝙢𝙖𝙜𝙡𝙪𝙩𝙞𝙙𝙚 & 𝙏𝙞𝙧𝙯𝙚𝙥𝙖𝙩𝙞𝙙𝙚): 𝙒𝙝𝙖𝙩 𝙋𝙖𝙩𝙞𝙚𝙣𝙩𝙨 𝙎𝙝𝙤𝙪𝙡𝙙 𝙆𝙣𝙤𝙬

Many patients have used compounded GLP-1 medications — not to judge or alarm.

✔️ Important points:
• Compounded GLP-1s are not FDA-approved, meaning they aren’t reviewed the same way as Ozempic®, Wegovy®, or Mounjaro®
• Some compounded versions may differ in ingredient form, concentration, or dosing
• Most reported side effects are similar to brand-name GLP-1s, but dosing errors are more common with compounded vials

🔎 If you are using a compounded GLP-1, it’s reasonable to:
• Confirm it comes from a licensed U.S. pharmacy
• Ask what form of the medication is used (this matters)
• Make sure dosing instructions are clear and well understood
• Store it properly (refrigerated) and check expiration dates

🌿 Bottom line:
Compounded GLP-1s were widely used during shortages. As availability improves, care decisions should focus on safety, transparency, and individualized guidance.

👩‍⚕️ Shared for patient education and safety from a clinical perspective.

💙 You deserve informed, respectful care — always.



𝘛𝘩𝘪𝘴 𝘤𝘰𝘯𝘵𝘦𝘯𝘵 𝘪𝘴 𝘴𝘩𝘢𝘳𝘦𝘥 𝘧𝘰𝘳 𝘨𝘦𝘯𝘦𝘳𝘢𝘭 𝘦𝘥𝘶𝘤𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘱𝘶𝘳𝘱𝘰𝘴𝘦𝘴 𝘰𝘯𝘭𝘺. 𝘐𝘵 𝘪𝘴 𝘯𝘰𝘵 𝘪𝘯𝘵𝘦𝘯𝘥𝘦𝘥 𝘵𝘰 𝘢𝘥𝘷𝘦𝘳𝘵𝘪𝘴𝘦, 𝘱𝘳𝘰𝘮𝘰𝘵𝘦, 𝘰𝘳 𝘦𝘯𝘥𝘰𝘳𝘴𝘦 𝘢𝘯𝘺 𝘴𝘱𝘦𝘤𝘪𝘧𝘪𝘤 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵, 𝘱𝘳𝘰𝘥𝘶𝘤𝘵, 𝘰𝘳 𝘴𝘦𝘳𝘷𝘪𝘤𝘦, 𝘯𝘰𝘳 𝘵𝘰 𝘳𝘦𝘱𝘭𝘢𝘤𝘦 𝘪𝘯𝘥𝘪𝘷𝘪𝘥𝘶𝘢𝘭𝘪𝘻𝘦𝘥 𝘮𝘦𝘥𝘪𝘤𝘢𝘭 𝘦𝘷𝘢𝘭𝘶𝘢𝘵𝘪𝘰𝘯.

12/12/2025

GLP-1 Medications (Ozempic®, Wegovy®, Mounjaro®, Zepbound®) and Lipedema — Clinical Overview

GLP-1 receptor agonists can offer meaningful metabolic and inflammatory benefits for some individuals with lipedema. While these medications support weight reduction and systemic health, current evidence indicates they do not selectively eliminate lipedema-specific adipose tissue.

Potential benefits may include:
• Reduction of non-lipedema (metabolic) fat
• Decreased systemic inflammation and fluid retention
• Improvement in pain, limb heaviness, and functional mobility in some patients
• Particularly helpful when lipedema coexists with obesity, insulin resistance, or metabolic syndrome

Current limitations:
• Do not specifically remove lipedema nodules
• Do not reverse fibrotic lipedema tissue
• Do not constitute a cure for lipedema

Clinical perspective:
Many patients experience overall body size reduction and symptomatic relief; however, disproportionate fat distribution in lipedema-affected areas may persist. GLP-1 therapies should be viewed as a supportive component of care, most effective when integrated with compression therapy, lymphatic support, individualized movement, and comprehensive medical management.

💙 Empowered patients make informed decisions


ᴛʜɪs ᴘᴏsᴛ ɪs ғᴏʀ ɢᴇɴᴇʀᴀʟ ᴇᴅᴜᴄᴀᴛɪᴏɴᴀʟ ᴘᴜʀᴘᴏsᴇs ᴏɴʟʏ ᴀɴᴅ ɪs ɴᴏᴛ ɪɴᴛᴇɴᴅᴇᴅ ᴀs ɪɴᴅɪᴠɪᴅᴜᴀʟ ᴍᴇᴅɪᴄᴀʟ ᴀᴅᴠɪᴄᴇ ᴏʀ ᴀ sᴜʙsᴛɪᴛᴜᴛᴇ ғᴏʀ ᴘʀᴏғᴇssɪᴏɴᴀʟ ᴇᴠᴀʟᴜᴀᴛɪᴏɴ.

06/07/2025

🔬 Connective Tissue Abnormalities in Lipedema
🧱 Structural Changes
• Thickened fibrotic septa divide fat lobules.
• Dense extracellular matrix (ECM) with excess collagen types I & III.
• Loss of tissue elasticity and reduced skin recoil.
💧 Fluid Retention
• ECM contains excess hyaluronic acid and proteoglycans, which hold water.
• Lymphatic drainage is impaired due to stiffened connective tissue → swelling and heaviness.
🩸 Capillary Fragility
• Fragile capillaries lead to easy bruising with minor pressure or trauma.
🔁 Chronic Inflammation & Tissue Remodeling
• Elevated matrix metalloproteinases (MMP-2, MMP-9) degrade collagen and alter ECM.
• Ongoing fibrosis and low-grade inflammation contribute to disease progression.
💡 Clinical Implications
• Fat is resistant to weight loss through diet or exercise.
• Symptoms include pain, swelling, heaviness, and sensitivity.
• Compression, manual lymphatic drainage (MLD), and liposuction help manage symptoms but do not reverse ECM fibrosis.

06/02/2025

Standard of care for lipedema in the United States

https://journals.sagepub.com/doi/epub/10.1177/02683555211015887

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06/02/2025

June is Lipedema Awareness Month — let’s raise awareness for this often misunderstood and underdiagnosed condition.

03/22/2025

Celebrating 🎉15 Years of Physmedi! 🧡💙
We’re proud to mark 15 years of compassionate care and medical excellence. Thank you to our incredible doctors, dedicated staff, and loyal patients who’ve made this journey possible

02/27/2025

🦋🌐💙

09/27/2024

Following the path of Hurricane 🌀 Helene, we will be open tomorrow, 9/27, during our regular operating hours. (352) 404-6959 www.physmedi.com

08/04/2024

🔬🧪🧬🦋

The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative health solutions for all.

07/09/2023

A voyage marked by service, love 💗 and commitment 🩺👩🏻‍🏫⚕️🎉.

12/25/2022

🦋 🎉🙌🏼

09/28/2022

We continue to follow the path of Hurricane Ian 🌀🌪
Please see the following updates to Physmedi regular operations:
1) Thursday:
Scheduled appointments will be conducted via telemedicine if weather permits. Offices will be closed.
2) Friday:
We hope to be able to open back our services 100% but this will be dictated by the path of the storm.
Stay safe everyone and please know we will do everything in our power to be open to serve you.