04/19/2026
Pennsylvania reports more Lyme disease cases than any other state in the country. About 30% of all recorded U.S. cases come from right here, and all 67 PA counties have both the blacklegged tick and documented cases of Lyme.
And tick season is back.
Here's what most people don't realize: in peer-reviewed research, the standard two-tiered Lyme blood test had only 48% sensitivity in early Lyme disease. That means it missed more than half of early-stage cases. It takes weeks for the body to develop enough antibodies to be detected, even when the classic rash is present.
Not everyone gets the bullseye rash. Some people carry Lyme for months or years before anyone connects the dots.
If you've been told your labs are "normal" but you still don't feel right (fatigue that won't quit, brain fog, joint pain, mystery symptoms no one can explain), tick-borne infection is worth investigating.
Sources:
Penn State Institutes of Energy and the Environment, "Understanding and preventing tick-borne disease in Pennsylvania": https://iee.psu.edu/news/blog/understanding-and-preventing-tick-borne-disease-pennsylvania
Branda JA, et al. "Two-tiered antibody testing for Lyme disease with use of 2 enzyme immunoassays, a whole-cell sonicate enzyme immunoassay followed by a VlsE C6 peptide enzyme immunoassay." Clinical Infectious Diseases, 2011 (PubMed): https://pubmed.ncbi.nlm.nih.gov/21865190/