Panama City Gastroenterology

08/25/2025

08/25/2025

Most viewed this week from JAMA Network Open: Living within close proximity to golf courses and in water service areas with golf courses was associated with a higher risk of developing disease.

https://ja.ma/45O9CVx

08/03/2025

Possible novel treatment of metabolic syndrome

Trapping gut microbiota produced molecule to improve blood sugar levels

A team of scientists has discovered a surprising new way to improve blood sugar levels and reduce liver damage: by trapping a little-known fuel made by gut bacteria before they wreak havoc on the body.

The findings, published in Cell Metabolism, could open the door to new therapies to treat metabolic diseases like type 2 diabetes and fatty liver disease.

Researchers showed that a molecule produced by microbes in the gut can sneak into the bloodstream and fuel the liver to make more glucose and fat than necessary. But when researchers developed a way to trap this molecule in the gut before it enters the body, they saw dramatic improvements in blood sugar control and fatty liver disease in mice with obesity.

The team found that obese mice — and even people with obesity — have higher levels of a lesser-known molecule, D-lactate, in their blood. Unlike the more familiar L-lactate made by muscles, most of the D-lactate comes from gut microbes and was shown to raise blood sugar and liver fat more aggressively.

To stop this, the researchers created a “gut substrate trap” — a safe, biodegradable polymer that binds to D-lactate in the gut and prevents it from being absorbed. Mice fed this trap had lower blood glucose, less insulin resistance, and reduced liver inflammation and fibrosis — all without changing their diet or body weight.

https://sciencemission.com/Trapping-gut-microbiota-molecule

08/02/2025

Patent foramen ovale (PFO) is present in approximately 25% of all adults and is a common cause of stroke in young and middle-aged patients.

This review discusses PFO-associated stroke management, comparing device closure with medical therapy, and highlights the PASCAL classification system for guiding treatment decisions and optimizing outcomes.

https://ja.ma/3U1yaVK

07/14/2025

Lower urinary tract symptoms are common among men and are usually caused by BPH, overactive bladder detrusor, or both.

This Narrative Review summarizes current evidence on the epidemiology, pathophysiology, diagnosis, and management of lower urinary tract symptoms in men.

https://ja.ma/4eJqbG4

07/13/2025

West Nile virus is an infection that is spread to humans by mosquitoes.

This JAMA Patient Page describes West Nile virus infection and its symptoms, diagnosis, treatment, and prevention measures.

https://ja.ma/4lmBDdl

07/07/2025

Staphylococcus aureus bacteremia has a case fatality rate of 15% to 30% and causes 300 000 deaths per year worldwide.

This Review discusses management of S aureus bacteremia.

https://ja.ma/40pjyDd

06/19/2025

Editorial: Addictive screen use in adolescents poses significant mental health risks beyond total screen time, necessitating targeted interventions.

https://ja.ma/3SUI1Mv

05/10/2025

This Medical News article highlights recent research into olfactory deficits in older adults and mortality risk, including factors that mediate this relationship.

04/27/2025

Model of Helicobacter pylori-associated Lesions According to Gastric Oncogenetic Cascade

04/24/2025

This JAMA Insights discusses lipoprotein(a), including factors associated with elevated lipoprotein(a) levels, how to manage them, and atherosclerotic cardiovascular disease risk.

04/24/2025

Pollen from grassland with nitrogen fertiliser may be more likely to trigger hay fever than pollen from unfertilised grasslands, study suggests.

Explore the latest data: https://hubs.li/Q03hNZVH0

👇 Figure: Schematic presentation of the study design.