Panama City Gastroenterology

03/25/2026

In a 10-year follow-up of the Appendicitis Acuta multicenter RCT, adult patients with uncomplicated treated with antibiotics experienced a recurrence rate of 37.8% and a cumulative appendectomy rate of 44.3%.

The cumulative complication rate was lower for the antibiotic group at 8.5% compared to 27.4% for those who underwent surgery.

https://ja.ma/4lO5U5Z

03/06/2026

The most common cause of hypothyroidism worldwide is insufficient intake of iodine, a mineral found in iodized salt and some foods (such as seafood and dairy) that is needed for production of thyroid hormones.

In the US and other high-income countries, the most common cause of hypothyroidism is an autoimmune condition called Hashimoto thyroiditis.

This JAMA Patient Page describes hypothyroidism and its risk factors, signs and symptoms, diagnosis, screening, and treatment.

https://ja.ma/4rKPhKx

01/27/2026

📊 Research Summary: Adults with atrial fibrillation who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine. Rates of hospitalization, heart failure, and stroke were similar, suggesting coffee may be safe for patients with AF.

https://ja.ma/4pVKWCr

12/28/2025

-1 receptor agonist exposure with discontinuation before or during early was associated with greater gestational weight gain and increased risk of preterm delivery, gestational , and hypertensive disorders in a cohort mainly composed of women with .

Effects on birth weight percentiles were modest, with no increase in risk of large or small for gestational age and no difference in cesarean delivery rates.

https://ja.ma/4b5j9vz

12/27/2025

vaccination before or during pregnancy was associated with lower risks of hospitalization, ICU admission, and preterm birth among those infected with SARS-CoV-2 in Canada.

https://ja.ma/4phDcdQ

11/29/2025

📢 ICYMI: This Review summarizes current evidence regarding the diagnosis and management of adult —with a focus on (OA), patellofemoral pain (PFP), and meniscal tears.

Knee pain drives about 5% of all primary care visits. Globally, OA impacts over 650 million adults, PFP has a lifetime prevalence of 25%, and meniscal tears affect 12% of the adult population. OA is most common in patients aged 45+; PFP typically affects younger, active individuals.

First-line therapy for all three conditions centers on exercise, education, weight loss (for OA), and self-management. Most meniscal tears and PFP improve with rehabilitation—surgery is reserved for select cases. These conservative approaches may reduce pain and improve function, minimizing adverse effects and disability.

📍 Add this Review to your reference manager. Link in the comments below. ⬇️

11/07/2025

Scabies is caused by a microscopic mite that burrows into the uppermost layer of the skin, causing intense itching and skin rash.

This JAMA Patient Page describes the contagious skin rash scabies, its transmission, signs and symptoms, diagnosis, and treatment.

https://ja.ma/49DzhUm

11/06/2025

disease is the fourth-leading outpatient gastrointestinal diagnosis, accounting for 4 million annual ambulatory care visits and annual health care expenditures of $1.3 billion. 🏥

Although not a life-threatening condition, hemorrhoidal disease reduces quality of life due to a**l bleeding, pruritus, re**al pain and pressure, and sensation of tissue prolapse.

🩺 This JAMA Review discusses the current evidence on the epidemiology, pathophysiology, diagnosis, and treatment of hemorrhoidal disease.

https://ja.ma/4qK3Gq7

10/10/2025

Case 1: A Lesson in Lipomas

A case of a duodenal submucosal lesion was presented, sparking a discussion on the diagnosis and management of lipomas.

read all 10 cases here: https://www.newsletter.endocollab.com/p/whatsapp-chat-summary-september-1

08/25/2025

08/25/2025

Most viewed this week from JAMA Network Open: Living within close proximity to golf courses and in water service areas with golf courses was associated with a higher risk of developing disease.

https://ja.ma/45O9CVx

08/03/2025

Possible novel treatment of metabolic syndrome

Trapping gut microbiota produced molecule to improve blood sugar levels

A team of scientists has discovered a surprising new way to improve blood sugar levels and reduce liver damage: by trapping a little-known fuel made by gut bacteria before they wreak havoc on the body.

The findings, published in Cell Metabolism, could open the door to new therapies to treat metabolic diseases like type 2 diabetes and fatty liver disease.

Researchers showed that a molecule produced by microbes in the gut can sneak into the bloodstream and fuel the liver to make more glucose and fat than necessary. But when researchers developed a way to trap this molecule in the gut before it enters the body, they saw dramatic improvements in blood sugar control and fatty liver disease in mice with obesity.

The team found that obese mice — and even people with obesity — have higher levels of a lesser-known molecule, D-lactate, in their blood. Unlike the more familiar L-lactate made by muscles, most of the D-lactate comes from gut microbes and was shown to raise blood sugar and liver fat more aggressively.

To stop this, the researchers created a “gut substrate trap” — a safe, biodegradable polymer that binds to D-lactate in the gut and prevents it from being absorbed. Mice fed this trap had lower blood glucose, less insulin resistance, and reduced liver inflammation and fibrosis — all without changing their diet or body weight.

https://sciencemission.com/Trapping-gut-microbiota-molecule