Dr. John Kruse, PO Box 38, Papaaloa, HI (2025)

11/24/2025

Weekly Q&A - 25 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/COb4y6NE_WQ

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Folate (Vitamin B9) for ADHD?
https://youtu.be/fRUOrmKZExk

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Folate (Vitamin B9) for ADHD?: Vitamin B9 is essential for manufacturing DNA, RNA, and several neurotransmitters, including dopamine and serotonin. Genetic studies reveal an association between gene variants of proteins involved in Vitamin B9 pathways and ADHD. But so far, almost no study has demonstrated that folate supplements have an impact on ADHD symptoms, or that maternal folate consumptions affects whether children develop ADHD. In contrast, many more studies show a connection between folate deficiencies and autism spectrum conditions.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles require

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

11/18/2025

y Q&A - 18 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/w1UACcLk9Pk

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Off Label Medications and Mental Health
https://youtu.be/GLhwZyUwQDc

- The Importance of Genetics for ADHD
https://youtu.be/RxvJqpq6G_4

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Off Label Medications and Mental Health:
Doctors can prescribe medications for purposes, at dosages, and to populations outside of what the FDA approves them for. But som**hing is off with the regulatory system when Spravato, a nasal spray form of esketamine for depression, is only available in one dose size, has to be administered in a doctor's office with two hours of monitoring, while oral, and IV ketamine can be used off label at any dose, including some that are high enough that they might be contributing to brain damage.

- The Importance of Genetics for ADHD:
Genetics have a very large influence over who develops ADHD, but it is not simply a few genes for dopamine receptors or transporters that are important. Hundreds of genes each play a small role, and epigenetic factors, and genetic maternal nuturance are also involved.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

11/15/2025

The FDA has a mandate to ensure that prescription medications are safe and effective. But it makes little sense that one form of ketamine, approved for depression, can only be used in a doctor's office, in a very restricted range of dosages, whereas other clinics can use ketamine to treat pain, depression, PTSD, ADHD and other conditions, at massively higher doses and frequencies, including potentially brain damaging amounts, because those uses are "off-label".

Free link for non-members of Medium: https://medium.com/wise-well/som**hings-off-with-off-label-prescribing-3253f72b8e92?sk=14cddae93941a32b2fa278c8f6c96a38

https://medium.com/wise-well/som**hings-off-with-off-label-prescribing-3253f72b8e92

Our current regulation of medications may be too lax to protect the public.

11/11/2025

Dr. John Kruse
6 minutes ago
Weekly Q&A - 11 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/glE1B-yF4Ac

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Narcolepsy and ADHD
https://youtu.be/rTjDwWcWOlw

- Is Hypersmell an ADHD Superpower?
https://youtu.be/Z7jVdtz8XoY

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Narcolepsy and ADHD: ADHD and narcolespsy are associated with each other. Excessive daytime sleepiness, and disturbances in night time sleep are common in ADHD. But a sophisticated technique called Mendelian randomization reveals that the connection is not causal; ADHD doesn't cause narcolepsy, and narcolepsy doesn't cause ADHD. Rather genes influencing dopamine pathways, autoimmune processes, iron metabolism, and glial cells can boost the likelihood of developing ADHD, or narcolepsy, or both.

- Is Hypersmell an ADHD Superpower?: Many individuals with ADHD report being more sensitive to smells compared to most of their peers. A few studies in children with ADHD have found a greater likelihood of super-sensitivity to odors, while the data on adults in much less extensive. Whether this is a blessing or a curse seems to depend a lot on what aroma is being detected.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

17:29
Now playing
Narcolepsy and ADHD

Dr. John Kruse
•
234 views
1 day ago
Main Chapters: 00:00 Intro – Narcolepsy and ADHD 00:10 Take home message 01:20 ADHD and Sleep 03:48 What is Narcolepsy? 09:29 Links Between Narcolepsy a

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ ADHD & mental health videos https://www.youtube.com/

11/06/2025

Much of medical research looking at the effects of diet, lifestyle, and medications, is correlational - it can show whether or not two variables are linked together. But a study design called Mendelian randomization, in many cases, allows scientists to make conclusions about causality - not just whether there is an association between the two, but also when one has a role in making the other happen.

Genetics provides a surprising way to help detect the causes of human physical and mental health conditions

11/04/2025

Weekly Q&A - 04 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/Vht5Ui8CRv8

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Violence and Thinking - Unthinking Violence
https://youtu.be/I8U1tBiGhjM

- Bright Light Therapy / Phototherapy for ADHD
https://youtu.be/94tlQGZaBco

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Violence and Thinking - Unthinking Violence:

Behavioral economist Jens Ludwig, in his 2025 book Unforgiving Places convincingly shows that most gun violence in the US is the result of impulsive, automatic thinking, not a reasoned calculation about the benefits and risks of killing harming someone. This means that we need to keep finding ways to help people shift from reflexive behavior to reflective behavior. It also indicates that many of the political strategies that have been used to combat gun violence are unlikely to work, because they misunderstand the underlying causes of gun violence.

- Bright Light Therapy / Phototherapy for ADHD:

Disruptions of sleep wake cycles and circadian rhythms are prominent among those with ADHD. Two studies, using the bright light treatments that are effective in treating seasonal depression, showed that these lights can improve ADHD symptoms, even in the absence of any depression. The extent of improvement correlated with how effective the lights were in shifting underlying circadian clocks.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ ADHD & mental health videos https://www.youtube.com/

10/29/2025

Unthinking gun violence. Most murders in the US aren't caused by evil people, poverty, or racism. We need to rethink what we believe about gun violence, because most murders aren't caused by faulty thinking - they're the result of people behaving automatically, impulsively, and quickly. Humans like to think of themselves as rational beings, but most of the decisions we make are rapid, unconscious responses, often based on wrong assumptions and faulty information. When guns are so readily available, misunderstandings and arguments quickly escalate to fatal consequences. The good news is that we can all learn to be more reflective, and less controlled by rapid, reflexes.

Unthinking Violence: We need to understand that 80% of gun murders are spontaneous, thoughtless, decisions.

10/27/2025

Weekly Q&A - 28 Oct 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/Msa72q1b92c

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European (6:00pm Central European this week for Daylight Savings)
www.youtube.com/

Videos released this week:
- A New Neurofeedback Approach for Mental Health
https://youtu.be/ET6UP-ak4L0

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- A New Neurofeedback Approach for Mental Health:

Even after more than half a century of treatments, neurofeedback for ADHD and most other mental health conditions has not yet been proven to be very effective. However, a new study on EEG based neurofeedback for m**hamphetamine abuse, using individualized protocols, and addressing whole-brain neural activation, showed marked success in suppressing m**h craving when exposed to cues.

This indicates the potential power not just an individualized approach, but that perhaps for most mental health conditions we need to be looking at what the whole brain is doing, not just targeted circuits like those involved in anticipation-and-reward, emotional regulation, or working memory.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ ADHD & mental health videos https://www.youtube.com/

10/22/2025

A common narrative is that feelings are disruptive and distracting to our rational minds. But emotions are not only essential, but provide us with useful information - as well as sometimes leading us astray. Understanding the differences between emotions and moods can help us better manage these feeling states, and aid us in responding to others.

Emotions, moods, and temperaments describe different things.

10/21/2025

Weekly Q&A - 21 Oct 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/C0BGopH9brI

Livestream every Tuesday at 10:00 am West Coast USA / 1:00 pm East Coast USA / 7:00 am Hawaii / 7:00 pm Central European
www.youtube.com/

Videos released this week:
- Screen Time, Social Media, and ADHD
https://youtu.be/6gLEYqlezgM

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Screen Time, Social Media, and ADHD:

Increasing evidence associates excessive amount of time spent online in front of phones or computers, and on social media, is associated with shorter attention spans, more distractibility, poorer impulse control, and less emotional regulation. Taking a break from being online anecdotally appears to be connected with an improvements in these executive functions. Whether our computer technology over the long term will change our individual brains and the whole organization of our society is a growing concern.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ ADHD & mental health videos https://www.youtube.com/

10/15/2025

Although neurofeedback has been around for more than half a century, much of the research using the technique has failed to find significant benefits for ADHD or a variety of other conditions. But a newer approach, using an EEG measurement of whole brain activity (not just one targeted region or brain wave) and individualizing each person's treatment, looks like it may lead to more powerful treatments.

An individualized approach to neurofeedback may finally make it a valued treatment for mental health conditions.

10/14/2025

Weekly Q&A - 14 Oct 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/xFsxnbw7Kv8

Livestream every Tuesday at 10:00 am West Coast USA / 1:00 pm East Coast USA / 7:00 am Hawaii / 7:00 pm Central European
www.youtube.com/

Videos released this week:
- Amlodipine for ADHD?
https://youtu.be/RXhC7NwdiTY

- Body Focused Repetitive Behaviors and ADHD
https://youtu.be/QBGU74P4ZIk

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Amlodipine for ADHD?: Harvard researcher Bruce Yankner and colleagues recently released a set of studies demonstrating that the calcium channel blocking, blood pressure lowering medication amlodipine may be helpful for ADHD. In animal models of ADHD (specific genetic strains of zebrafish and rats) amlodipine decreased hyperactivity and impulsivity. Amlodipine does get into the brain, and affects the activation of certain genes in the brain. Complex genetic studies suggest that amlodipine could help with ADHD through its effects on calcium channel proteins, and that individuals taking amlodipine may display fewer ADHD symptoms. But we're still waiting for direct studies giving amlodipine to individuals with ADHD.

- Body Focused Repetitive Behaviors and ADHD: Hairpulling, skin picking, and nail biting are among the most common body focused repetitive behaviors. These behaviors appear to have similarities to social grooming behaviors in rodents and primates. Although formerly associated with Obsessive Compulsive Disorder (OCD), BFRB appears to more closely connected to the impulsivity of ADHD. New research suggests that glutamate blocking or modulating medications and supplements such as memantine, or N-Acetylcysteine (NAC) may be helpful in treating BFRB.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ ADHD & mental health videos https://www.youtube.com/

Dr. John Kruse

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