Dr. John Kruse, PO Box 38, Papaaloa, HI (2026)

01/08/2026

You're already consuming tyrosine in any protein you eat. Unlike many other widely hyped products, tyrosine supplements really do have the potential to boost neurotransmitters - specifically dopamine and norepinephrine. Very limited evidence suggests that this can help cognitive functioning for peopele with depression, ADHD, or who are feeling stressed out. But some research indicates that too much tyrosine can actually impair performance.

Free link for non-members of Medium: https://medium.com/wise-well/are-tyrosine-supplements-helpful-hurtful-or-just-cheesy-2ec1e3ab1aef?sk=b4960ccffb69ddb9476a51f862657a9b

https://medium.com/wise-well/are-tyrosine-supplements-helpful-hurtful-or-just-cheesy-2ec1e3ab1aef

This amino acid supplement can boost brain functioning — but too much or too little causes problems.

01/05/2026

Weekly Q&A - 06 Jan 2026 - Welcome to the New Year

Join me for my Weekly Q&A at:
https://youtube.com/live/92zz_0HY7EI

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- 50 Years of Adult ADHD:
https://youtu.be/1VHgqvrw2uI

- ADHD and the Amygdala:
https://youtu.be/L0WlbpRXojg

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- 50 Years of Adult ADHD:

In 1926 Paul Wender and others at the University of Utah published the first study documenting that ADHD persists into adulthood and responds to the same medications that help those with childhood ADHD. In the half century since then there is much greater awareness and acceptance of ADHD, along with more treatment options, but still a lot of room for improvement remains.

- ADHD and the Amygdala:

Much of the research and popular awareness of ADHD focuses on the prefrontal cortex, which contains much of the circuitry involved in executive functions. But other parts of the brain are involved with ADHD as well, including the amgydala, an almond sized and shaped cluster of cells long known to be associated with emotional regulation. One 2024 study demonstrated that neurofeedback directed at amygdala activity improved emotional regulation and other symptoms of ADHD.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

01/02/2026

2026 marks fifty years from the first article documenting that children's ADHD symptoms can persist into adulthood and can be treated by the same medications that work for childhood ADHD. Both the world, and our understanding of ADHD have changed a lot since then....

Free link for non-members of Medium: https://medium.com/wise-well/why-we-should-celebrate-50-years-of-recognizing-adult-adhd-a62ce52eec1f?sk=d7b8388c5c05b30dc93bf35d490c223d

https://medium.com/wise-well/why-we-should-celebrate-50-years-of-recognizing-adult-adhd-a62ce52eec1f

A half-century of research on adult ADHD clarifies that it is a common, lifelong, serious condition that increasingly affects our world

12/26/2025

Many people are terrified of dementia but less familiar with the brain and behaviroal changes associated with healthy aging - and the differences are more subtle than one might think.......

Mental decline evokes strong feelings, but in research and the clinic, human diversity compounds the difficulty of differentiating healthy…

12/22/2025

Weekly Q&A - 23 Dec 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/KGn7sVfxTqM

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Take a holiday! No Q & A for next Tuesday (12/30/25) but I'll be back in the New Year (1/6/2026).

Videos released this week:
- Brain Aging and Mental Health
https://youtu.be/U3qZXIt1LPI

Normal aging is associated with declines in cognitive processing speeds, more

- Can One Factor Explain All Mental Health Conditions? - The p-Factor
https://youtu.be/eio46cYTa1w

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Brain Aging and Mental Health:

difficulty shifting cognitive frameworks, and more challenges processing new information. Many of these decreases start by one's early 30's, and there is considerable overlap between normal aging and ADHD - all 9 inattentive ADHD symptoms and the 4 impulsive symptoms all coincide with what are often called "senior moments". Sorting out dementia, normal aging and ADHD can be challenging in older adults.

- Can One Factor Explain All Mental Health Conditions? - The p-Factor:

While the number of diagnoses within the DSM continues to grow - to well over 200, other research suggests that one underlying process may explain a significant part of all mental health conditions. But interpretation of studies looking at the structure and relationship between mental health conditions is constrained by how we measure mental health symptoms, and some experts think that the underlying factor for psychiatric pathology - the "p-Factor" is mostly an artifact of how we assess the severity of impairment in mental health conditions.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

12/18/2025

Influencers are increasingly promoting natural supplements to improve brain health, and two golden yellow spices -- saffron and turmeric -- are near the top of many lists. Both spices have been used in traditional medicine for mood and anxiety problems and to enhance alertness. Research on lab animals indicate that saffron and curcumin, a biologically active compound abundant in turmeric, can reduce inflammation, act as effect anti-oxidants, and modulate neurotransmitter levels. Human studies indicate that these spices may play a role for many in treating depression, dementia, ADHD and other mental health conditions.

Studies suggest spices can help with depression, dementia and ADHD, but reservations are warranted

12/16/2025

Weekly Q&A - 16 Dec 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/kaz1ynaANgw

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Saffron and Curcumin (Turmeric) for ADHD?
https://youtu.be/uKEKoSpAXto

- Weighted Blankets and ADHD
https://youtu.be/2Pr8-YfYy9s

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Saffron and Curcumin (Turmeric) for ADHD?:

Interest in spices and other supplements to treat ADHD and other mental health conditions has been increasing. The bright yellow spices saffron and turmeric have both been used for centuries in food, cosmetics and folk medicine. Recent research indicates that both of these spices contain chemicals that reduce inflammation, reduce oxidative stress and modulate neurotransmitters. Four studies of saffron in humans indicate it can help reduce symptoms of ADHD. As of now there are no human studies of curcumin/turmeric for treating ADHD, but some animal research suggests it may help.

- Weighted Blankets and ADHD:

Some people find weighted blankets comforting and soothing, and they are frequently recommended for those with ADHD. A small amount of research suggests that they can reduce anxiety, boost mood, and may help those with ADHD function better in the daytime.

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You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

12/05/2025

So far, the medications that seem most helpful for decreasing symptoms of dementia involve I.V. infusions and pose a risk of brain swelling and other complications. But the serotonin modulating antidepressant Trintellix (vortioxetine) also seems capable of improving cognition, not just in depression, but in dementia and other mental health conditions as well.

Vortioxetine (Trintellix) boosts cognitive performance not just in depression, but for those with dementia, schizophrenia, and other…

12/02/2025

Weekly Q&A - 02 Dec 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/Okr5BNA-Ljo

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

(Next week 12/9/25 there will NOT be a live Q & A.)

Videos released this week:

- Assortative Mating and ADHD - Seeking Romantic Partners with ADHD
https://youtu.be/QXvR7-ahEMY

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Assortative Mating and ADHD - Seeking Romantic Partners with ADHD: Assortative Mating refers to like seeking like - tall people have a slight preference for matching with other tall people, and wealthy people with other wealthy people. How much of assortative mating is biologically driven and how much is culturally driven varies with each trait. There is some evidence to support that there is assortative mating with respect to ADHD - that partners have a tendency to resemble each other regarding where they fall on the ADHD spectrum.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

11/24/2025

Weekly Q&A - 25 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/COb4y6NE_WQ

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Folate (Vitamin B9) for ADHD?
https://youtu.be/fRUOrmKZExk

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Folate (Vitamin B9) for ADHD?: Vitamin B9 is essential for manufacturing DNA, RNA, and several neurotransmitters, including dopamine and serotonin. Genetic studies reveal an association between gene variants of proteins involved in Vitamin B9 pathways and ADHD. But so far, almost no study has demonstrated that folate supplements have an impact on ADHD symptoms, or that maternal folate consumptions affects whether children develop ADHD. In contrast, many more studies show a connection between folate deficiencies and autism spectrum conditions.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles require

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

11/18/2025

y Q&A - 18 Nov 2025

Join me for my Weekly Q&A at:
https://youtube.com/live/w1UACcLk9Pk

Livestream every Tuesday at 10:00am West Coast USA / 1:00pm East Coast USA / 7:00am Hawaii / 7:00pm Central European
www.youtube.com/

Videos released this week:
- Off Label Medications and Mental Health
https://youtu.be/GLhwZyUwQDc

- The Importance of Genetics for ADHD
https://youtu.be/RxvJqpq6G_4

After a short recap of each video, I’ll be available for questions on these topics or any other related to Mental Health.

- Off Label Medications and Mental Health:
Doctors can prescribe medications for purposes, at dosages, and to populations outside of what the FDA approves them for. But something is off with the regulatory system when Spravato, a nasal spray form of esketamine for depression, is only available in one dose size, has to be administered in a doctor's office with two hours of monitoring, while oral, and IV ketamine can be used off label at any dose, including some that are high enough that they might be contributing to brain damage.

- The Importance of Genetics for ADHD:
Genetics have a very large influence over who develops ADHD, but it is not simply a few genes for dopamine receptors or transporters that are important. Hundreds of genes each play a small role, and epigenetic factors, and genetic maternal nuturance are also involved.

-----
You can also discuss and ask questions on my Reddit page:
https://www.reddit.com/r/Drjohnkruse

If you have ideas for additional talks, or other feedback, let me know:
drjohnkruse@gmail.com

My Medium page with hundreds of articles on Mental Health and other subjects:
https://dockruse.medium.com
Access to full articles requires paid membership.

Read writing from John Kruse MD, PhD on Medium. Psychiatrist, neuroscientist, gay father of twins, marathon runner, in Hawaii. 200+ free ADHD & mental health videos at: https://www.youtube.com/

11/15/2025

The FDA has a mandate to ensure that prescription medications are safe and effective. But it makes little sense that one form of ketamine, approved for depression, can only be used in a doctor's office, in a very restricted range of dosages, whereas other clinics can use ketamine to treat pain, depression, PTSD, ADHD and other conditions, at massively higher doses and frequencies, including potentially brain damaging amounts, because those uses are "off-label".

Free link for non-members of Medium: https://medium.com/wise-well/somethings-off-with-off-label-prescribing-3253f72b8e92?sk=14cddae93941a32b2fa278c8f6c96a38

https://medium.com/wise-well/somethings-off-with-off-label-prescribing-3253f72b8e92

Our current regulation of medications may be too lax to protect the public.

Dr. John Kruse

01/08/2026

01/05/2026

01/02/2026

12/26/2025

12/22/2025

12/18/2025

12/16/2025

12/05/2025

12/02/2025

11/24/2025

11/18/2025

11/15/2025

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