BioSpherix, Ltd.

01/20/2023

Join us at ASME's free webinar to discuss exciting advancements in biomedical innovation! Register now: https://asme.zoom.us/webinar/register/WN_JNE5jmzNTa-T__C_frLgmw

12/21/2022

Have your cell cultures been naughty this year, or nice?
Happy Holidays, from the BioSpherix family.

12/01/2022

Enhanced Self-Renewal of HSC Under Physioxia:
Physioxia induces downregulation of Tet2 in Hematopoietic Stem Cells, report Aljoufi et al.

Read more (open access): https://ashpublications.org/blood/article/doi/10.1182/blood.2022015499/485747/Physioxia-induced-Downregulation-of-Tet2-in

11/30/2022

Goal: discuss and identify measurement needs for characterizing biofabricated, tissue en

11/29/2022

Physioxia Influences Gene Methylation:
Dogan et al. use physiological oxygen to examine epigenetic modification in pluripotent stem cells.

Read more (open access): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148100/

11/28/2022

The goal of the alliance is to allow cell-based therapies to be manufactured cost-effectively with superior efficacy and safety.

11/21/2022

Osteogenesis and HIF Signaling in the Clinic: An in-depth review of recent progress in HIF-regulated bone regeneration provides evidence for novel tissue repair strategies.

Read more: https://pubmed.ncbi.nlm.nih.gov/35913258/

Bone tissue destruction leads to severe pain, physical flaws, and loss of motility. Bone repair using biocompatible and osteo-inductive scaffolds is regarded as a viable and potential therapeutic approach. However, for large-scale bone regeneration, oxygen and nutrient supply have become limiting fa...

11/17/2022

Altering O2 in Solid Tumor Studies:
Herrera-Campos et al. review the role of hyperoxia and the immune system in novel treatments for solid tumors.

Read more (open access): https://www.mdpi.com/2072-6694/14/11/2740/htm

Hyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the....

11/16/2022

Identifying EV Uptake Signals in Pancreatic Cancer: Nigri et al. mimic pathophysiologic conditions to identify a potential target for therapeutic intervention into aggressive pancreatic ductal carcinoma.

Read more (open access): https://pubmed.ncbi.nlm.nih.gov/35917363/

In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in metastatic progression. Tumor-stroma cross-talk is often mediated through extracellular vesicles (EVs). We previously reported that EVs derived from cancer-associated stromal fibroblasts (CAFs) that are abundan...

11/14/2022

Intestinal Wound Healing and HIF: Steiner et al. review the double-edged sword HIF present over the course of the metabolic response to chronic intestinal inflammation.

Read more: https://pubmed.ncbi.nlm.nih.gov/35912990/

The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells provide a selectively permeable barrier to luminal contents and normally do so in an efficient and effective manner. Barrier function in the healthy mucosa is provided via several mechanisms including epithel...

11/10/2022

Relevant miRNA patterns under pathophysioxia:
Majewska et al. study the role of PTEN in kidney cancer by mimicking the TME in vitro.

Read more (open access): https://pubmed.ncbi.nlm.nih.gov/35625614/

MicroRNAs are post-transcriptional regulators of gene expression, and disturbances of their expression are the basis of many pathological states, including cancers. The miRNA pattern in the context of tumor microenvironment explains mechanisms related to cancer progression and provides a potential t...

11/09/2022

Neuroinflammation Regulation Therapies Tested Using Hypoxia: Wang et al. recreate pathophysiological conditions to study neuroprotection after cardiac arrest-induced brain injury.

Read more: https://pubmed.ncbi.nlm.nih.gov/35921049/

Cardiac arrest (CA) is common and devastating, and neuroprotective therapies for brain injury after CA remain limited. Neuroinflammation has been a target for two promising but underdeveloped post-CA therapies: neural stem cell (NSC) engrafting and glibenclamide (GBC). It is critical to understand w...

11/07/2022

Goldilocks, Radiation, and Cataracts in Space:
Richard B. Richardson details the role of oxygen in cataract development in US astronauts.

Read more (open access): https://pubmed.ncbi.nlm.nih.gov/35917999/

This article explores the role that oxygen levels in US spacecraft from 1961 to 1998 have on the development of cataracts induced by space radiation in astronauts and whether oxygen levels are well accounted for in experimental studies examining cataractogenesis. The first epidemiological report in....

11/03/2022

Physioxia Diminishes Cellular Iron Dependency: New biosensors uncover altered cell metabolism in this study by Sevimli et al.

Read more (open access): https://www.sciencedirect.com/science/article/pii/S221323172200091X

Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficie…

11/01/2022

Simulating Pathological Hypoxia to Study Neurodegeneration:
Thinard et al. discuss a novel approach to therapy at the blood brain barrier.

Read more (open access): https://www.mdpi.com/1999-4923/14/7/1418

The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering effect of the BBB may be a reason for the lack of therapeutic effect. However, there is no treatment, as yet, for the amyotrophic lateral...

10/27/2022

Oxygen Controls the Lymphovascular-Immune Ensemble:
Schito et al. review the role of hypoxia in the lymphatic system's response to cancer.
Read more: https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00095-4?

The lymphatic system is a major component of the tumor microenvironment, wherein lymphovascular remodeling occurs as a response to low O2 (hypoxia), resulting in metastatic dissemination and patient mortality. Further to this notion, recent data have brought forth an expanded view of lymphatics, bey...

10/26/2022

B Cell Function, Development, and Metabolism are Regulated by HIF: A comprehensive review by Zhang et al. of immunoregulation by hypoxia and hypoxia-inducible factors.

Read more (open access): https://www.frontiersin.org/articles/10.3389/fimmu.2022.967576/full

Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important...

10/25/2022

A Novel Photosynthetic Gel for Wound Healing:
Developing novel treatments can require novel approaches, like that of Zhu et al., who mimicked peripheral artery disease in vitro to develop a novel topical gel to enhance localized hyperoxygenation.

Read more (open access): https://www.nature.com/articles/s41598-022-14085-1

Peripheral artery disease and the associated ischemic wounds are substantial causes of global morbidity and mortality, affecting over 200 million people worldwide. Although advancements have been made in preventive, pharmacologic, and surgical strategies to treat this disease, ischemic wounds, a con...