09/23/2025
The JAMA study following 2.5 million children over 25 years found no link between Tylenol use in pregnancy and autism, ADHD, or intellectual disability.
https://jamanetwork.com/journals/jama/fullarticle/2817406
💡 Why trust the JAMA study?
- JAMA (Journal of the American Medical Association) is one of the world’s leading, peer-reviewed medical journals. Articles go through rigorous evaluation by other experts before they’re published.
JAMA Network
- This specific study included 2,480,797 children born in Sweden over 25 years, with detailed birth, medical-record, and follow-up data. That kind of sample size gives a lot of statistical power.
JAMA Network
- It used a sibling-control design, which means comparing outcomes in children whose mothers did use acetaminophen during one pregnancy vs another pregnancy when they didn’t. That helps account for genetic, environmental, and familial factors.
JAMA Network
- The results? In those sibling comparisons, there was no association between acetaminophen use in pregnancy and autism, ADHD, or intellectual disability. That strongly suggests earlier findings arose from confounding, not causation.
