09/27/2023
Weight Loss Therapy
Although treatment for weight loss has typically been done by endocrinologists, the impact of obesity is obvious in terms of cardiovascular disease, stroke as well as weight bearing joint arthritis. There is considerable data that weight loss can improve arthritis in hips and knees.
Initial therapy entails behavioral lifestyle changes, exercise, caloric restriction with as much elimination of sugar as possible. Billions of dollars are spent annually on weight loss programs. Unfortunately the success rate is poor. Bariatric surgery even for adolescents has become a growth industry and it is a generally more successful treatment than the above endeavors. However many of our patients who
have had bariatric surgery regain much of the initial weight loss as they eat smaller amounts of food more frequently.
Drug therapy has historically been problematic. Amphetamines were used 60 years ago and are still taken for weight loss. Many of you may remember “Fen/Phen” which caused weight loss but also was associated with heart valve problems.
Drugs that have been available for diabetes also can cause weight loss and have become popular in the last year. Typically they can cause a 15% weight loss which is sustainable as long as patients remain on medication. If they stop, without behavioral modification, the weight can return. The 2 most popular
drugs which are actually one and the same (semaglutide) are Ozempic and Wegovy. Ozempic is approved for diabetics with a BMI above 26 and Wegovy is approved for weight loss if your BMI is above 30. They are both weekly injections and the dose is typically increased with time. They cannot be used in people with a history of pancreatitis and there is a risk of gallbladder disease from these drugs. The
data strongly indicates that weight loss is associated with a decrease in cardiovascular related disease and stroke. The weight loss drugs, however ,do not help congestive heart failure.
The major side effect from these medications is vomiting which is related to the fact that one of the ways these drugs work is by slowing down the transit of food through your stomach. If you eat when your stomach tells you that it is full, there is literally no place for the food to go other than by vomiting. Being aware of the sensation of fullness largely corrects this problem.
Unfortunately Wegovy is difficult to get currently as it is largely out of stock but will be back by October 2023. Without insurance, these drugs are expensive at approximately $1300 monthly.
There is a more potent drug on the market, Mounjaro (terzepitide) also given by self injection. Some insurance companies have approved it for weight loss and with time, it will become more accepted by other insurance companies. Weight loss from Mounjaro can exceed 20% of total body weight; vomiting can be an issue as would be expected. More drugs can be expected to come to the market in the next
few years.
If you are interested in these medications, you should either talk to your primary care physician, endocrinologist or us at Main Line Rheumatology. 610-896-8400 www.mainlinerheumatology.com
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