Journal of Pediatric Gastroenterology and Nutrition

Journal of Pediatric Gastroenterology and Nutrition ​The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original pape

The Journal of Pediatric Gastroenterology and Nutrition provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.

🌀🧒 Dolichocolon in children: more common than we think?In this study of pediatric patients undergoing contrast e***a for...
04/09/2026

🌀🧒 Dolichocolon in children: more common than we think?

In this study of pediatric patients undergoing contrast e***a for constipation, dolichocolon (elongated colon) was identified in a large proportion—especially in younger children.

📌 Key findings:
• Present in 74–89% of children ≤4 years with constipation
• Prevalence decreased with age (≈48% in adolescents)
• Associated with constipation and other GI symptoms

🧠 Take-home: Dolichocolon may be a common (and possibly congenital) contributor to constipation in pediatric patients, particularly early in life.

🔗 https://doi.org/10.1002/jpn3.70291?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🧬🧒 Primary intestinal lymphangiectasia: outcomes and long-term trajectoryIn this national cohort of children with primar...
04/08/2026

🧬🧒 Primary intestinal lymphangiectasia: outcomes and long-term trajectory

In this national cohort of children with primary intestinal lymphangiectasia (PIL), most patients responded well to dietary therapy—with a subset achieving long-term remission.

📌 Key findings:
• 81% responded to low long-chain triglyceride diet
• Only 12% required second-line therapy
• 45% tolerated reintroduction of a normal diet
• 26% achieved sustained remission (“cure”)

🧠 Take-home: While many children have a chronic course with partial response, a meaningful subset can achieve complete remission, highlighting heterogeneity in disease trajectory.

🔗 https://doi.org/10.1002/jpn3.70266?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

📹🧒 Capsule endoscopy in pediatrics: when does it change care?In this large pediatric series (478 studies), small bowel v...
04/08/2026

📹🧒 Capsule endoscopy in pediatrics: when does it change care?

In this large pediatric series (478 studies), small bowel video capsule endoscopy (VCE) demonstrated strong diagnostic utility—but impact varied by indication.

📌 Key findings:
• 51% of studies were positive
• 35% led to changes in therapy or diagnosis
• Lower yield and impact when used for isolated abdominal pain

🧠 Take-home: VCE is a valuable tool for small bowel disease, but patient selection matters—yield is lower when used for nonspecific abdominal pain.

🔗 https://doi.org/10.1002/jpn3.70288?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

Looking for a high-impact home for your pediatric GI, hepatology, or nutrition research?Submit to The Journal of Pediatr...
04/08/2026

Looking for a high-impact home for your pediatric GI, hepatology, or nutrition research?

Submit to The Journal of Pediatric Gastroenterology and Nutrition (JPGN)—the official journal of NASPGHAN and ESPGHAN.

📈 Impact Factor 2.4
✅ Free color, no page fees
⚡ Fast-track available for select high-impact submissions
🌐 Open access option
🧒 Wide reach across pediatric GI communities

📄 Author Guidelines: https://onlinelibrary.wiley.com/page/journal/15364801/homepage/author-guidelines?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

📥 Submit here: https://www2.cloud.editorialmanager.com/jpgn/default2.aspx?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🩸🟡 Variceal bleeding in biliary atresia: is “standard” secondary prophylaxis happening?In this large multicenter cohort,...
04/07/2026

🩸🟡 Variceal bleeding in biliary atresia: is “standard” secondary prophylaxis happening?

In this large multicenter cohort, real-world management of variceal hemorrhage (VH) in biliary atresia varied widely—and often diverged from guideline-based secondary prophylaxis.

📌 Key findings:
• Only a minority underwent repeated endoscopic therapy to variceal eradication
• 39% had no endoscopic evaluation after bleeding
• Rebleeding rates were relatively low in many groups
• Native liver survival was similar regardless of endoscopic intervention

🧠 Take-home: Pediatric practice appears more individualized than guideline-driven, with transplant candidacy and clinical context shaping decisions more than routine secondary prophylaxis.

🔗 https://doi.org/10.1002/jpn3.70281

🧬🟡 Hepatitis-associated aplastic anemia (HAAA): recognizing early signalsThis study highlights key clinical features of ...
04/07/2026

🧬🟡 Hepatitis-associated aplastic anemia (HAAA): recognizing early signals

This study highlights key clinical features of pediatric HAAA, a rare but serious condition where acute hepatitis precedes bone marrow failure.

📌 Key findings:
• Severe cholestatic hepatitis (ALT often >2000 U/L, high bilirubin)
• Cytopenia develops quickly (median 3 weeks after hepatitis onset)
• Early lymphopenia is a distinguishing feature
• Hepatic recovery is common, though some develop acute liver failure

🧠 Take-home: Severe hepatitis + early lymphopenia should raise suspicion for HAAA and may enable earlier diagnosis and monitoring for bone marrow failure.

🔗 https://doi.org/10.1002/jpn3.70308?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🫁🟡 Hepatopulmonary syndrome in pediatric portal hypertension: often silent, clinically importantIn this multicenter Braz...
04/06/2026

🫁🟡 Hepatopulmonary syndrome in pediatric portal hypertension: often silent, clinically important

In this multicenter Brazilian study, hepatopulmonary syndrome (HPS) in children with portal hypertension was frequently underrecognized and not reliably detected by pulse oximetry alone.

📌 Key findings:
• 44% of patients were asymptomatic at diagnosis
• SpO₂ may miss hypoxemia (normal SpO₂ despite low PaO₂)
• Elevated hemoglobin may signal underlying hypoxemia
• Post-transplant survival remained high (≈85% at 1 year), regardless of HPS severity

🧠 Take-home: HPS can be clinically silent and underdetected—relying on SpO₂ alone may miss cases. Early recognition is key, but severity does not appear to impact transplant outcomes.

🔗 https://doi.org/10.1002/jpn3.70306?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🟡👶 Tailored steroids after Kasai: improving bile drainage and survivalIn infants with biliary atresia, a tailored postop...
04/06/2026

🟡👶 Tailored steroids after Kasai: improving bile drainage and survival

In infants with biliary atresia, a tailored postoperative steroid protocol based on stool color and histology was associated with improved outcomes after Kasai portoenterostomy.

📌 Key findings:
• Lower 3-month bilirubin (0.9 vs 6.5 mg/dL)
• Higher 2-year native liver survival (72.9% vs 37.5%)
• No increase in LOS, complications, or readmissions

🧠 Take-home: A selective, phenotype-driven steroid approach may improve bile drainage and long-term outcomes without added risk.

🔗 https://doi.org/10.1002/jpn3.70292?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🧬🫀 ETI and liver disease in cystic fibrosis: early signals, but limited structural changeIn this prospective PUSH study,...
04/04/2026

🧬🫀 ETI and liver disease in cystic fibrosis: early signals, but limited structural change

In this prospective PUSH study, elexacaftor/tezacaftor/ivacaftor (ETI) was associated with improvements in key hepatobiliary biomarkers in children with CF.

📌 Key findings:
• Improved lung function (+3.4% FEV₁/year) and weight gain
• Decreases in GGT (−15%/yr) and ALT (−12%/yr)
• Improved GGT-to-platelet ratio in CF-related liver disease
• No change in liver stiffness or ultrasound classification

🧠 Take-home: ETI may provide early biochemical improvement in CF liver disease, but structural liver changes may take longer to emerge.

🔗 https://doi.org/10.1002/jpn3.70290?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🫀🧒 MASLD in children: early cardiovascular risk is already detectableIn this Original Article from a Mexican pediatric c...
04/04/2026

🫀🧒 MASLD in children: early cardiovascular risk is already detectable

In this Original Article from a Mexican pediatric cohort, children with metabolic-dysfunction-associated steatotic liver disease (MASLD) showed clear signs of early cardiometabolic risk.

📌 Key findings:
• Higher BMI percentiles, systolic BP, and insulin resistance
• Increased carotid intima-media thickness (CIMT) → marker of early atherosclerosis
• CIMT: 0.74 mm vs 0.56 mm in controls

📊 A combined model using:
• CIMT
• Metabolic markers
• Liver enzymes
→ showed very high predictive accuracy (R² = 0.935)

🧠 Take-home: MASLD is not just a liver disease — it is strongly linked to early vascular changes and cardiovascular risk in children.

These findings support earlier, multifactorial risk assessment in pediatric MASLD.

🔗 https://doi.org/10.1002/jpn3.70287?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

🫀🩺 Blood type matters: Are pediatric liver allocation policies disadvantaging some patients?This Original Article analyz...
04/03/2026

🫀🩺 Blood type matters: Are pediatric liver allocation policies disadvantaging some patients?

This Original Article analyzes UNOS data (2008–2022) to assess the impact of ABO matching in pediatric liver transplantation.

📊 Key findings:
• 20% of transplants were ABO non-identical
• Non-identical transplants enabled shorter wait times for high-acuity patients
• But created inequity across blood groups

⚠️ Blood type O candidates:
• Longer waitlist time (62.5 vs 48 days)
• Lower likelihood of transplant

📈 Meanwhile:
• Blood type A (and others) experienced a net gain in allografts
• Blood type O experienced a net loss of organs

🧠 Take-home: Policies allowing ABO non-identical transplants may improve access for some — but at the cost of disadvantaging children with blood type O.

These findings could inform future allocation policy changes in pediatric liver transplantation.

🔗 https://doi.org/10.1002/jpn3.70272?utm_source=fb_page&utm_medium=Journal+of+Pediatric+Gastroenterology+and+Nutrition&utm_campaign=publer

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