Annals of Internal Medicine: Clinical Cases

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Annals of Internal Medicine: Clinical Cases

A partnership between the American College of Physicians and the American Heart Association, AIMCC i

02/13/2026

Researchers describe an older patient living with polycythemia vera and monoclonal gammopathy of undetermined significance (MGUS) who was ultimately found to have wild‑type transthyretin cardiac amyloidosis (ATTRwt), not the more common amyloid light-chain (AL) amyloidosis. This case underscores the importance of performing histologic typing and not assuming AL amyloidosis in MGUS patients. https://bit.ly/3O9q79v

02/12/2026

A case report from West Virginia University shows how self-medicating with for a persistent headache masked key autonomic symptoms in hemicrania continua in a 49-year-old woman, delaying diagnosis for nearly a year. Once ibuprofen intake stopped, symptoms emerged and treatment with indomethacin resolved the headache within 24 hours. Read the full text for free: https://bit.ly/3OcfZwL

02/11/2026

A new case report details a 39-year-old woman with (MPS IIIA) presenting with late‑onset cardiac and ocular symptoms, not typical neurocognitive decline. This case highlights the need to consider late-onset lysosomal storage disorders in adults with unexplained hypertrophic cardiomyopathy. Read the case for free here: https://bit.ly/4quKdsg

02/07/2026

A new case report details a novel approach to a rare complication of chronic lymphocytic leukemia (CLL) and illustrates a new treatment path for patients who experience local complications of otherwise low-risk CLL. https://bit.ly/3O9poVK

02/06/2026

A new case report details a decade‑long diagnostic delay in isolated perianal Crohn disease, emphasizing the importance of biopsy, imaging, and early differentiation from mimicking conditions. Read here: https://bit.ly/4kisFOy

02/05/2026

A new case report underscores the importance of heightened scrutiny of supplement use and consideration of patients’ cultural and religious practices. Authors detail the case of a 47-year-old man taking multiple over-the-counter supplements while fasting during Ramadan who developed a rare form of kidney stone. Read now for free: https://bit.ly/3ZjZNfi

02/04/2026

A new image case study characterizes an unusual cutaneous manifestation in a patient with confirmed cutaneous leishmaniasis. This case emphasizes the broad spectrum of cutaneous lesions and underscores the potential for misdiagnosis. https://bit.ly/4rnAQeE

01/31/2026

Copublished by the American College of Physicians (ACP) and American Heart Association, Annals of Internal Medicine: Clinical Cases is a peer-reviewed, open access journal that publishes case reports on topics across the spectrum of medicine. Learn how to prepare and submit your manuscript here: https://bit.ly/4a4TzEK

01/30/2026

Guttate psoriasis is typically seen in younger patients following streptococcal infection, but presentations can differ in the setting of . A case report details an adult man with advanced untreated HIV who developed a diffuse, scaly rash unresponsive to empiric antibiotics, which was later confirmed as guttate psoriasis. The case underscores the diagnostic complexity of dermatologic findings in HIV. https://bit.ly/4a71otG

01/29/2026

A new case report describes an isolated esophageal metastasis of renal cell carcinoma discovered 45 years after initial treatment. To the author's knowledge, this is the longest relapse documented to date. Read the full text for free: https://bit.ly/4tmRWLM

01/27/2026

A new case from University of Colorado School of Medicine highlights atypical skull base osteomyelitis (SBO) caused by Streptococcus parasanguinis from a sinus infection. This unique presentation can inform clinicians to include SBO in their differential diagnosis in a patient with headaches and other nonspecific symptoms, which can expedite diagnosis and treatment of the condition. https://bit.ly/4t0Tivm

01/23/2026

The case of a 45-year-old man with hypertrophic obstructive cardiomyopathy was diagnosed with chronic Q fever after Lymphoma was initially suspected. This case highlights the complexity of diagnosing granulomatous disease and the importance of including chronic Q fever in the differential diagnosis. https://bit.ly/46cifKq

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