Annals of Internal Medicine: Clinical Cases

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Annals of Internal Medicine: Clinical Cases

A partnership between the American College of Physicians and the American Heart Association, AIMCC i

12/12/2025

Vaginal squamous cell carcinoma is rare and often overlooked. A recent case report highlights an unusual presentation in an 87-year-old woman and highlights the importance of considering vaginal cancer in postmenopausal women with atypical sexual symptoms. https://f.mtr.cool/nibkcvaouz

12/11/2025

A case report details an almost 4-year-old child with a nasal-tip lesion treated at home with witch hazel and hydrocortisone cream. These home remedies altered its appearance and delayed the ultimate diagnosis of impetigo, a highly contagious skin infection. This case emphasizes the importance of clinicians inquiring about nonprescription treatments to reveal potential masked symptoms. https://f.mtr.cool/xgwrduqevy

12/09/2025

The rare case of a 78-year-old man with a diffuse large B-cell lymphoma (DLBCL) mimicking an abdominal aortic aneurysm rupture illustrates the importance for clinicians to maintain a broad differential, as early recognition may avoid unnecessary surgery and enable appropriate oncologic management. https://f.mtr.cool/bbpcylhabn

12/06/2025

A patient with presumed Crohn disease was nonresponsive to numerous advanced therapies. After further evaluation, he was diagnosed with IgG4-related disease (IgG4-RD), a rare chronic immune-mediated inflammatory disorder. This case demonstrates the necessity of maintaining a high index of suspicion for IgG4-RD in patients who present with atypical signs of inflammatory bowel disease. Read for free here: https://f.mtr.cool/dyqmudatjo

12/05/2025

Gitelman syndrome (GS) is a rare, autosomal-recessive salt-losing tubulopathy often requiring lifelong electrolyte supplementation. A new case report describes a patient with GS who initiated tacrolimus, a calcineurin phosphatase inhibitor, after orthotopic heart transplantation. The patient achieved normokalemia and improved blood pressure without needing potassium supplements. Read the full text for free: https://f.mtr.cool/fdhomcsdur

12/04/2025

New: A case report from UK College of Medicine describes a 22-year-old patient who developed knee osteonecrosis after short-term bevacizumab therapy. This case highlights the importance of considering MRI for unexplained joint pain in patients on vascular endothelial growth factor inhibitors. https://f.mtr.cool/nngubdhigu

12/02/2025

Interleukin-17 inhibitors offer targeted treatment for autoimmune diseases, but a recent case report highlights serious risks. Authors from University of Tennessee Health Science Center detail what they believe is the first known case of Fournier gangrene as a potential adverse effect of ixekizumab use. Read the full text for free here: https://f.mtr.cool/szmvdqrcaf

11/28/2025

A young healthy man who presented with 3 weeks of upper back pain was diagnosed with disseminated blastomycosis, a fungal infection usually found along the shores of lakes and rivers in the Midwestern and Southeastern United States. This case report emphasizes the importance of considering fungal infections in the differential diagnosis of infiltrative skeletal lesions, particularly in endemic regions where blastomycosis remains underdiagnosed and underreported. https://f.mtr.cool/euznyhdlie

11/27/2025

Copublished by American College of Physicians (ACP) and American Heart Association, Annals of Internal Medicine: Clinical Cases is a peer-reviewed, open access journal that publishes case reports on topics across the spectrum of medicine. Learn how to prepare and submit your manuscript here: https://f.mtr.cool/kvrhhcacji

11/26/2025

A case report details a young woman whose granulomatosis with polyangiitis (GPA) presented as a recurrent pituitary mass, initially mistaken for infection. This rare and complex case highlights the importance of considering GPA in patients with recurrent pituitary masses, especially without response to IV antibiotics. https://f.mtr.cool/dviuxtnqmk

11/25/2025

A recent case report from UCLA Health highlights the diagnostic challenges of Pancreatitis, Panniculitis, and Polyarthritis (PPP) syndrome. Early diagnosis of PPP syndrome remains challenging because rheumatologic findings often overshadow gastrointestinal symptoms. This case underscores the importance of multidisciplinary evaluation and the role of immunohistochemistry in diagnosis. https://f.mtr.cool/jjcshaurdy

11/24/2025

A 54-year-old man who presented with dengue fever and abdominal pain was found to have intestinal perforation due to dengue fever, a complication rarely documented in medical literature. This case underscores the importance of recognizing rare manifestations of fever, especially as its geographic range expands with climate change. https://f.mtr.cool/okgbgdtypf

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