Annals of Internal Medicine: Clinical Cases

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Annals of Internal Medicine: Clinical Cases

A partnership between the American College of Physicians and the American Heart Association, AIMCC i

04/03/2026

Infectious aortitis is a rare and potentially fatal condition that can arise from gastrointestinal infections. A case series presents two cases of aortitis caused by gastrointestinal bacteria and reviews the management of this complex syndrome, highlighting signs that may support earlier diagnosis and treatment. Read now: https://bit.ly/4sxpJ3j

04/02/2026

DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) is a severe hypersensitivity syndrome with multiorgan involvement. A new case report illustrates a rare, severe DRESS phenotype with simultaneous rhabdomyolysis and probable myocarditis. Read the full text for free: https://bit.ly/4bXLdzW

04/01/2026

A rare case report describes pericardial tamponade due to Entamoeba histolytica in a U.S. patient with no recent travel history. The case underscores the need to consider parasitic causes of pericardial disease, even outside endemic regions. https://bit.ly/4m7f9hG

03/27/2026

Read online for free now: Authors highlight a case of colonic plasmablastic lymphoma (PBL) that developed during immunosuppressive therapy for ulcerative colitis. Colonoscopies showed a shift from ulcers to elevated lesions before widespread metastasis. This case demonstrates a unique endoscopic phenotypic transition in colonic PBL. https://bit.ly/4uMwyA6

03/26/2026

A new case report describes an older man who underwent home sleep apnea testing that showed unexplained persistent low oxygen levels which was later found to be due to a large pulmonary embolism. This case highlights the importance of being on the lookout for atypical data trends that may signal a different problem requiring attention. https://bit.ly/47V8h0U

03/25/2026

NEW: Authors from UT MD Anderson Cancer Center report, to their knowledge, the first documented case of hyperbaric oxygen therapy treating treatment-resistant ICI colitis, highlighting the importance of considering alternative strategies in a complex case. https://bit.ly/3O0rtne

03/24/2026

A 67-year-old woman experienced annual bouts of pneumonia since the age of 9 that had notably worsened in recent years and required hospitalizations. Genetic testing showed . This case highlights the importance of maintaining a broad differential diagnosis for recurrent pulmonary infections. Read the full text for free: https://bit.ly/3PFPf8t

03/20/2026

Progressive multifocal leukoencephalopathy (PML) is a rare but devastating brain infection caused by reactivation of the John Cunningham virus in people with weakened immune systems. A new case report shows how chronic kidney disease, even without other causes of immune suppression, can be an important risk factor. Read the full text for free: https://bit.ly/4uGNsA1

03/19/2026

A new case report highlights a rare complication of community-acquired pneumonia and exemplifies the importance of maintaining a broad differential in all patients. https://bit.ly/3Pvn9wB

03/17/2026

A 19-year-old went to the emergency department with persistent nausea and vomiting a week after getting his wisdom teeth removed. Imaging showed an abscess near the jaw that had spread toward the skull, a rare but potentially life-threatening condition.

The infection worsened quickly, and he needed antibiotics and surgery to drain it. This case highlights why it’s important to recognize symptoms early and start treatment right away when infections develop in this area of the face. https://bit.ly/4uGYIwz

03/13/2026

Authors from UAB Heersink School of Medicine report a rare case of a recurrent cerebrospinal fluid (CSF) pseudocyst causing small bowel obstruction in an adult with a long-standing ventriculoperitoneal (VP) shunt for congenital hydrocephalus. https://bit.ly/4ssbWfb

03/12/2026

Insulin autoimmune syndrome (IAS) is a rare but important cause of hypoglycemia. A new case highlights how biochemical clues including fluctuating ketone levels can guide timely diagnosis and help avoid unnecessary diagnostic procedures. https://bit.ly/3P77yTV

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