07/23/2025
**NEW IN JVIR:** The Impact of Chronic Kidney Disease on Amputation and Death Rates in Patients with Peripheral Artery Disease in the United States
🔍 **Clinical Question:**
Does chronic kidney disease (CKD) affect the incidence of amputation and death among patients with peripheral artery disease (PAD) in the United States?
đź’ˇ **Key Insight:**
Patients with peripheral artery disease (PAD) with chronic kidney disease (CKD) Stage 5 had 4 times higher amputation rates (31.3% vs 7.8%) and 5 times higher mortality (4.7% vs 0.9%) than those with PAD without CKD.
Patients with PAD, CKD Stage 5, and diabetes had an amputation rate of 36.5%.
Patients with PAD on dialysis showed significantly higher estimates for amputation and death compared with patients with PAD not on dialysis.
👉 **Why it matters:**
Diabetes tripled the amputation rate in patients with PAD and CKD Stages 1–4 (26.1% vs 8.7%) and doubled the amputation rate in those with PAD and CKD Stage 5 (36.5% vs 15.9%).
➡️ **Full Article:** https://www.jvir.org/article/S1051-0443(25)00250-7/fulltext
