Pediatric T Cell ALL-Leukemia: Raising Awareness- Bluesun Foundation

Pediatric T Cell ALL-Leukemia: Raising Awareness- Bluesun Foundation Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing nearly one third of all pediatric cancers.

The annual incidence of acute lymphoblastic leukemia within the United States is 3.7-4.9 cases per 100,000 children age 0-14 years,[1] with a peak incidence in children aged 2-5 years. With improvements in diagnosis and treatment, overall cure rates for children with acute lymphoblastic leukemia have reached 90%.[3] The use of risk-adapted treatment protocols has improved cure rates while limiting the toxicity of therapy. This article summarizes the current diagnosis and treatment of childhood acute lymphoblastic leukemia. In acute lymphoblastic leukemia (ALL), a lymphoid progenitor cell becomes genetically altered and subsequently undergoes dysregulated proliferation, with clonal expansion. In ALL, the transformed lymphoid cells reflect the altered expression of genes usually involved in the normal development of B cells and T cells. Several studies indicate that leukemic stem cells are present in certain types of acute lymphoblastic leukemia. Fore more info on childhood Leukemia classifications : http://www.cancer.org/cancer/leukemiainchildren/detailedguide/childhood-leukemia-how-classified

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