11/06/2025
If you noticed long COVID came with unexpected food reactions, flushing, itching, or symptoms that seem to appear out of nowhere, you're not imagining it.
Mast cell activation syndrome (MCAS) is emerging as a significant player in post-viral illness.
Mast cells are immune sentinels stationed throughout your body in your gut, skin, lungs, and brain. Their job is to release chemical mediators like histamine when they detect a threat. In long COVID, these cells often remain in a hyper activated state.
So what you're experiencing is NOT a food allergy in the traditional sense, but an immune dysregulation.
And this dysregulation is causing a cascade of seemingly unrelated symptoms: brain fog, fatigue, digestive distress, skin reactions, anxiety, temperature dysregulation, and pain that moves around the body.
The common thread is histamine and other mediators triggering inflammation across multiple systems.