The Hurwitz Lab

04/29/2023

Join me as I sit down with Dr. Jeffrey Rimmer, a nephrologist from the University of Vermont Health Network, to discuss his CKD Navigator program. As we dive into the details of this (clinical pilot) program, Dr. Rimmer explains how it aims to optimize care, reduce costs, and improve the patient experience for individuals with late-stage kidney disease. We talk about the challenges faced by those with kidney disease, the complexities of navigating the healthcare system, and the ways in which the CKD Navigator program addresses these issues. Dr. Rimmer shares insights on the program's development, implementation, and outcomes to date, highlighting the successes and challenges encountered along the way. If you're interested in the future of healthcare, chronic disease management, and patient-centered care don't miss this.

Join me as I sit down with Dr. Jeffrey Rimmer, a nephrologist from the University of Vermont Health Network, to discuss his CKD Navigator program. As we dive...

04/03/2023

Join me as I sit down (via zoom) with Jack Hurwitz (my son), an AI programmer for the department of defense, and delve into the fascinating world of artificial intelligence, deep learning, and large language models. Jack shares his insights on the groundbreaking advancements that led to the evolution of ChatGPT, from its inception to the state-of-the-art ChatGPT4. During our conversation, Jack emphasizes the significance of deep learning algorithms, massive datasets, and increased computational power in the development of these models. He also touches upon the ethical considerations and potential implications of these AI technologies, while addressing the progress they have brought to fields such as natural language understanding, translation, and creativity. This thought-provoking discussion serves as an excellent resource for anyone interested in the cutting-edge advancements and the future of AI.

https://www.youtube.com/watch?v=Q2JPhNzG63Q

03/20/2022

Medical and Science Friends:

After watching our videos on Salt and Water and also Sodium Transport Along the Nephron you now have all the requisite tools to join us for a detailed look at Diabetes Insipidus. Armed with the control system model Alan does a fantastic job outlining the interplay between thirst, AVP, the AVP2 Receptor and Aquaporin 2. If you ever wanted to understand disorders leading to hypertonicity then this is the video for you!

https://youtu.be/20bUSAj7oGw

02/07/2022

Medical/Science Friends:

For years we've known that kidney disease sets into motion rapid ageing and a very high risk for cardiovascular disease. Disordered mineral metabolism is at the center and in recent years the fields of phosphorus dysregulation and ageing have collided as we've learned about FGF23 and Klotho. In this video Alan and I discuss our current understanding of this newer FGF-Klotho endocrine system and it's impact on renal disease, cardiovascular disease and ageing. Don't miss this video if you want to live long and prosper!

https://youtu.be/QOZ7XLMsS0k

For years we've known that kidney disease sets into motion rapid ageing and a very high risk for cardiovascular disease. Disordered mineral metabolism is at...

01/27/2022

Medical / Science friends:

Interested in Hypertension? From ancient China through Guytonian theory all the way to the most up-to-date societal guidelines this video leaves no stone unturned. We discuss history, philosophy (Plato's Allegory of the cave), physiology, medical management and future directions in Hypertension. This is one of the most comprehensive hypertension reviews you will find - just turn the cameras on and let Alan do his thing! Brace yourself!!

https://youtu.be/qQlXSnicSA0

Interested in Hypertension? From ancient China through Guytonian theory all the way to the most up-to-date societal guidelines this video leaves no stone un...

01/11/2022

(to my Medical/Science minded friends!)

This video is an epic tour of the nephron with a comprehensive review of salt transport. Alan will discuss each segment of the nephron with respect to the epithelial transport features along with a review of physio-pharmaco-genetics. Alan is an expert in the field of ion channels and epithelial transport and this review is like no other I've seen. If you want to understand salt balance, how diuretics work, tubulopathies (inherited and acquired) and of course blood pressure then this is the talk for you! Don't forget to like and subscribe to our channel!

https://youtu.be/IVAzJ8zhssk

This video is an epic tour of the nephron with a comprehensive review of salt transport. Alan will discuss each segment of the nephron with respect to the e...

01/02/2022

You've reviewed the chapters and watched the videos but still don't quite get CounterCurrent Multiplication do you!! I've been where you are! This is one of the more challenging topics on how the AMAZING KIDNEY creates a huge osmotic gradient needed to keep us from dying of dehydration. In this video Alan and I discuss and review the current understanding of countercurrent multiplication and make it tangible. Now I know you can do this... let's go!

https://youtu.be/RCxd-4qbwYs

You've reviewed the chapters and watched the videos but still don't quite get CounterCurrent Multiplication do you!! I've been where you are! This is one o...

12/23/2021

What could be better on a holiday weekend than a good review of Acute Kidney Injury!!

Acute kidney Injury is the most common reason I get called for a "kidney consult" at the hospital. Most commonly it's secondary to a severe illness like sepsis, kidney toxic exposures (nephrotoxins) or ischemia (low FLOW to the kidney). It's a syndrome that has many causes and Alan does an amazing job walking us through the topic of AKI by presenting actual cases he has seen over the years. He talks about biomarkers (or lack of), risk factors, prognosis and more. Don't miss this clinically relevant review!

https://youtu.be/D7VpoWEVBVo

Acute kidney Injury is the most common reason I get called for a "kidney consult" at the hospital. Most commonly it's secondary to a severe illness like sep...

12/14/2021

https://youtu.be/RaHeZBNzsmQ

In this episode Alan and I discuss Flow. We are all so caught up with PRESSURE (or driving force) that we miss the important point that life is all about FLOW. Alan does a great job helping understand the relationship of flow and driving force and how it applies to the kidney. At the end he presents his novel electrical model of the Glomerulus to help us understand the regulation of glomerular hemodynamics in health and disease.

In this episode Alan and I discuss Flow. We are all so caught up with PRESSURE (or driving force) that we miss the important that life is all about FLOW. A...

12/07/2021

In this episode Alan is back to complete our physiology TRIFECTA by discussing potassium. While talking about water and protons was a total blast on our previous podcasts, Potassium is really Alan's wheelhouse. I really enjoyed this podcast and although I've worked on potassium channels in Alan's lab and I've been in clinical nephrology practice for 20 years now I still walked away with new lessons that will impact how I practice medicine. If you love potassium you will love this podcast!! Enjoy (don't forget to like and subscribe to THL)

https://youtu.be/kdY-YYkCdfQ

12/07/2021

In this episode I have Dr. Alan Segal back to teach (and excite) us about the topic of Acid-Base balance. This topic can be one of the most daunting but Alan guides us through all of the disorders and an sensible approach to diagnosing them. Enjoy the "emia's" and "oses" of Acid-Base balance.

https://youtu.be/nu1284_fWzE

12/07/2021

In this episode I speak with my nephrology mentor Dr. Alan Segal. We focused this discussion on the topic of TONICITY disorders and understanding the physiology of water homeostasis in health and disease. If you've been confused by "hyponatremia" then you will really enjoy this discussion. Alan also presents his 2021 ASN poster (hot off the press) on a non-linear correction for [Na] in the setting of hyperglycemia. Enjoy!!

https://www.youtube.com/watch?v=7xAIXirr51Q